View in EDS HTML Full Text PDF Full Text

Developing Therapies for Depression in Drug Dependence: Results of a Stage 1 Therapy Study.

Saved in:
Bibliographic Details
Title: Developing Therapies for Depression in Drug Dependence: Results of a Stage 1 Therapy Study.
Authors: Carpenter, Kenneth M. (AUTHOR), Smith, Jennifer L. (AUTHOR), Aharonovich, Efrat (AUTHOR), Nunes, Edward V. (AUTHOR)
Source: American Journal of Drug & Alcohol Abuse. 2008, Vol. 34 Issue 5, p642-652. 11p. 2 Charts.
Subjects: Treatment of drug addiction, Mental depression, Therapeutics, Drug use testing, Depressed persons, Drug administration, Medical care, Methadone treatment programs, Comorbidity
Abstract: Objective: This Stage 1b controlled trial sought a preliminary test of the relative efficacy of Behavioral Therapy for Depression in Drug Dependence (BTDD) against a structured relaxation intervention (REL) for treating DSM-IV depressive disorders and substance abuse. Method: Thirty-eight methadone maintained opiate dependent participants, who met criteria for a DSM-IV depressive disorder, were randomized to one of two, 24-week treatment conditions (BTDD or REL). Results: Depression response, defined as at least a 50% reduction in Hamilton Depression Scale score from baseline to the end of study, was high and similar in both BTDD (61%) and REL (65%). Rates of drug use were low overall, both at baseline and at the end of study, and did not differ between treatment groups at study endpoint. Conclusions: The findings suggest that both behavioral- and relaxation-based approaches show promise for treating comorbid depression in drug dependent populations. Future work should examine combining or modifying these interventions to target substance use more directly and include values based methods for increasing more adaptive behavioral patterns. [ABSTRACT FROM AUTHOR]
Copyright of American Journal of Drug & Alcohol Abuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 34506818
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Developing Therapies for Depression in Drug Dependence: Results of a Stage 1 Therapy Study.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Carpenter%2C+Kenneth+M%2E%22">Carpenter, Kenneth M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Smith%2C+Jennifer+L%2E%22">Smith, Jennifer L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aharonovich%2C+Efrat%22">Aharonovich, Efrat</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nunes%2C+Edward+V%2E%22">Nunes, Edward V.</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Drug+%26+Alcohol+Abuse%22">American Journal of Drug & Alcohol Abuse</searchLink>. 2008, Vol. 34 Issue 5, p642-652. 11p. 2 Charts.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Treatment+of+drug+addiction%22">Treatment of drug addiction</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+use+testing%22">Drug use testing</searchLink><br /><searchLink fieldCode="DE" term="%22Depressed+persons%22">Depressed persons</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+administration%22">Drug administration</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+care%22">Medical care</searchLink><br /><searchLink fieldCode="DE" term="%22Methadone+treatment+programs%22">Methadone treatment programs</searchLink><br /><searchLink fieldCode="DE" term="%22Comorbidity%22">Comorbidity</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective: This Stage 1b controlled trial sought a preliminary test of the relative efficacy of Behavioral Therapy for Depression in Drug Dependence (BTDD) against a structured relaxation intervention (REL) for treating DSM-IV depressive disorders and substance abuse. Method: Thirty-eight methadone maintained opiate dependent participants, who met criteria for a DSM-IV depressive disorder, were randomized to one of two, 24-week treatment conditions (BTDD or REL). Results: Depression response, defined as at least a 50% reduction in Hamilton Depression Scale score from baseline to the end of study, was high and similar in both BTDD (61%) and REL (65%). Rates of drug use were low overall, both at baseline and at the end of study, and did not differ between treatment groups at study endpoint. Conclusions: The findings suggest that both behavioral- and relaxation-based approaches show promise for treating comorbid depression in drug dependent populations. Future work should examine combining or modifying these interventions to target substance use more directly and include values based methods for increasing more adaptive behavioral patterns. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of American Journal of Drug & Alcohol Abuse is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=34506818
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/00952990802308171
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 11
        StartPage: 642
    Subjects:
      – SubjectFull: Treatment of drug addiction
        Type: general
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Therapeutics
        Type: general
      – SubjectFull: Drug use testing
        Type: general
      – SubjectFull: Depressed persons
        Type: general
      – SubjectFull: Drug administration
        Type: general
      – SubjectFull: Medical care
        Type: general
      – SubjectFull: Methadone treatment programs
        Type: general
      – SubjectFull: Comorbidity
        Type: general
    Titles:
      – TitleFull: Developing Therapies for Depression in Drug Dependence: Results of a Stage 1 Therapy Study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Carpenter, Kenneth M.
      – PersonEntity:
          Name:
            NameFull: Smith, Jennifer L.
      – PersonEntity:
          Name:
            NameFull: Aharonovich, Efrat
      – PersonEntity:
          Name:
            NameFull: Nunes, Edward V.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 09
              Text: 2008
              Type: published
              Y: 2008
          Identifiers:
            – Type: issn-print
              Value: 00952990
          Numbering:
            – Type: volume
              Value: 34
            – Type: issue
              Value: 5
          Titles:
            – TitleFull: American Journal of Drug & Alcohol Abuse
              Type: main
ResultId 1