Dilatation in the femoral vascular bed does not cause retrograde relaxation of the iliac artery in the anaesthetized pig.
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| Title: | Dilatation in the femoral vascular bed does not cause retrograde relaxation of the iliac artery in the anaesthetized pig. |
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| Authors: | Markos, F., Ruane-O'Hora, T., Snow, H. M., Kelly, R., Wainwright, C., Skene, K., Drake-Holland, A. J., Noble, M. I. M. |
| Source: | Acta Physiologica. Nov2008, Vol. 194 Issue 3, p207-213. 7p. 1 Diagram, 2 Charts, 2 Graphs. |
| Subjects: | Arteries, Iliac artery, Acetylcholine, Pentobarbital, Nitric oxide, Swine |
| Abstract: | Aim: We tested the hypothesis that dilatation of a feeding artery may be elicited by transmission of a signal through the tissue of the arterial wall from a vasodilated peripheral vascular bed. Methods: In eight pentobarbital anaesthetized pigs, acetylcholine (ACh, an endothelium-dependent vasodilator) was injected intra-arterially above (upstream) and below (downstream) a test segment of the left iliac artery, the diameter of which was measured continuously by sonomicrometry. Results: Under control conditions, ACh injections upstream and downstream of the test segment caused dilatation. Downstream injection dilated the peripheral arterioles, resulting in increased blood flow and proximal dilatation. This is a shear stress, nitric oxide (NO)-dependent response. The experiment was then repeated after applying a stenosis to prevent the increased flow caused by downstream injection of ACh; the stenosis was placed either above the site of diameter measurement to allow retrograde conduction, or below that site to prevent distally injected ACh reaching the measurement site. Under these conditions, downstream injection of ACh had a minimal effect on the shear stress of the test segment with no increase in test segment diameter. This was not due to endothelial damage or dysfunction as injection of ACh upstream still caused a large increase in test segment diameter. Conclusions: Our results indicate that dilatation of the feeding artery of a vasodilated bed is caused by increased shear stress within the feeding artery and not via a signal transmitted through the arterial wall from below. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 34643746 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Dilatation in the femoral vascular bed does not cause retrograde relaxation of the iliac artery in the anaesthetized pig. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Markos%2C+F%2E%22">Markos, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Ruane-O'Hora%2C+T%2E%22">Ruane-O'Hora, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Snow%2C+H%2E+M%2E%22">Snow, H. M.</searchLink><br /><searchLink fieldCode="AR" term="%22Kelly%2C+R%2E%22">Kelly, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Wainwright%2C+C%2E%22">Wainwright, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Skene%2C+K%2E%22">Skene, K.</searchLink><br /><searchLink fieldCode="AR" term="%22Drake-Holland%2C+A%2E+J%2E%22">Drake-Holland, A. J.</searchLink><br /><searchLink fieldCode="AR" term="%22Noble%2C+M%2E+I%2E+M%2E%22">Noble, M. I. M.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Physiologica%22">Acta Physiologica</searchLink>. Nov2008, Vol. 194 Issue 3, p207-213. 7p. 1 Diagram, 2 Charts, 2 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Arteries%22">Arteries</searchLink><br /><searchLink fieldCode="DE" term="%22Iliac+artery%22">Iliac artery</searchLink><br /><searchLink fieldCode="DE" term="%22Acetylcholine%22">Acetylcholine</searchLink><br /><searchLink fieldCode="DE" term="%22Pentobarbital%22">Pentobarbital</searchLink><br /><searchLink fieldCode="DE" term="%22Nitric+oxide%22">Nitric oxide</searchLink><br /><searchLink fieldCode="DE" term="%22Swine%22">Swine</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Aim: We tested the hypothesis that dilatation of a feeding artery may be elicited by transmission of a signal through the tissue of the arterial wall from a vasodilated peripheral vascular bed. Methods: In eight pentobarbital anaesthetized pigs, acetylcholine (ACh, an endothelium-dependent vasodilator) was injected intra-arterially above (upstream) and below (downstream) a test segment of the left iliac artery, the diameter of which was measured continuously by sonomicrometry. Results: Under control conditions, ACh injections upstream and downstream of the test segment caused dilatation. Downstream injection dilated the peripheral arterioles, resulting in increased blood flow and proximal dilatation. This is a shear stress, nitric oxide (NO)-dependent response. The experiment was then repeated after applying a stenosis to prevent the increased flow caused by downstream injection of ACh; the stenosis was placed either above the site of diameter measurement to allow retrograde conduction, or below that site to prevent distally injected ACh reaching the measurement site. Under these conditions, downstream injection of ACh had a minimal effect on the shear stress of the test segment with no increase in test segment diameter. This was not due to endothelial damage or dysfunction as injection of ACh upstream still caused a large increase in test segment diameter. Conclusions: Our results indicate that dilatation of the feeding artery of a vasodilated bed is caused by increased shear stress within the feeding artery and not via a signal transmitted through the arterial wall from below. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/j.1748-1716.2008.01882.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 207 Subjects: – SubjectFull: Arteries Type: general – SubjectFull: Iliac artery Type: general – SubjectFull: Acetylcholine Type: general – SubjectFull: Pentobarbital Type: general – SubjectFull: Nitric oxide Type: general – SubjectFull: Swine Type: general Titles: – TitleFull: Dilatation in the femoral vascular bed does not cause retrograde relaxation of the iliac artery in the anaesthetized pig. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Markos, F. – PersonEntity: Name: NameFull: Ruane-O'Hora, T. – PersonEntity: Name: NameFull: Snow, H. M. – PersonEntity: Name: NameFull: Kelly, R. – PersonEntity: Name: NameFull: Wainwright, C. – PersonEntity: Name: NameFull: Skene, K. – PersonEntity: Name: NameFull: Drake-Holland, A. J. – PersonEntity: Name: NameFull: Noble, M. I. M. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2008 Type: published Y: 2008 Identifiers: – Type: issn-print Value: 17481708 Numbering: – Type: volume Value: 194 – Type: issue Value: 3 Titles: – TitleFull: Acta Physiologica Type: main |
| ResultId | 1 |
