Clinical implications of the CATIE schizophrenia trials: day-to-day management lessons for Australasian psychiatrists.
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| Title: | Clinical implications of the CATIE schizophrenia trials: day-to-day management lessons for Australasian psychiatrists. |
|---|---|
| Authors: | Bick, Peter, Knoesen, Natalie, Castle, David |
| Source: | Australasian Psychiatry. Dec2007, Vol. 15 Issue 6, p465-469. 5p. 1 Diagram. |
| Subjects: | Antipsychotic agents, Schizophrenia, Drug side effects, Clinical trials, Psychiatrists, National Institute of Mental Health (U.S.) |
| Geographic Terms: | United States |
| Abstract: | Objective: The aim of this paper was to review whether the $50m spent by the US National Institute of Mental Health in doing the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) trials found any useful evidence to change the clinical management of schizophrenia by psychiatrists. Conclusion: The CATIE trials were conducted in the US on 1460 enrolled patients in an effort to track how the drugs used to treat schizophrenia actually work in clinical practice (rather than in 6-week clinical trials). In a complex 3- phase design, patients were randomized to various types of (mostly) atypical antipsychotic drugs. Some 69-74% of patients switched antipsychotics for one reason or another during the 18 months of treatment. Some of the results were expensive confirmations of known prior results; of the commonly prescribed drugs, clozapine was the most effective, and olanzapine and ziprasidone caused the most and fewest metabolic side effects, respectively. The most stunning finding was that psychiatrists tend to ignore life-threatening, treatable medical conditions in patients presenting for treatment with schizophrenia. Of patients entering the study, 45% had untreated diabetes, 89% had untreated hyperlipidemias and 62% had untreated hypertension. This study failed to reveal anything of significant importance in the psychopharmacological treatment of schizophrenia, but did expose a woeful standard in the medical management of schizophrenia offered by psychiatrists. Psychiatrists should learn to properly treat diabetes, hyperlipidemia and hypertension when detected. [ABSTRACT FROM AUTHOR] |
| Copyright of Australasian Psychiatry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 34660039 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Clinical implications of the CATIE schizophrenia trials: day-to-day management lessons for Australasian psychiatrists. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Bick%2C+Peter%22">Bick, Peter</searchLink><br /><searchLink fieldCode="AR" term="%22Knoesen%2C+Natalie%22">Knoesen, Natalie</searchLink><br /><searchLink fieldCode="AR" term="%22Castle%2C+David%22">Castle, David</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Australasian+Psychiatry%22">Australasian Psychiatry</searchLink>. Dec2007, Vol. 15 Issue 6, p465-469. 5p. 1 Diagram. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Antipsychotic+agents%22">Antipsychotic agents</searchLink><br /><searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+side+effects%22">Drug side effects</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+trials%22">Clinical trials</searchLink><br /><searchLink fieldCode="DE" term="%22Psychiatrists%22">Psychiatrists</searchLink><br /><searchLink fieldCode="DE" term="%22National+Institute+of+Mental+Health+%28U%2ES%2E%29%22">National Institute of Mental Health (U.S.)</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22United+States%22">United States</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objective: The aim of this paper was to review whether the $50m spent by the US National Institute of Mental Health in doing the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) trials found any useful evidence to change the clinical management of schizophrenia by psychiatrists. Conclusion: The CATIE trials were conducted in the US on 1460 enrolled patients in an effort to track how the drugs used to treat schizophrenia actually work in clinical practice (rather than in 6-week clinical trials). In a complex 3- phase design, patients were randomized to various types of (mostly) atypical antipsychotic drugs. Some 69-74% of patients switched antipsychotics for one reason or another during the 18 months of treatment. Some of the results were expensive confirmations of known prior results; of the commonly prescribed drugs, clozapine was the most effective, and olanzapine and ziprasidone caused the most and fewest metabolic side effects, respectively. The most stunning finding was that psychiatrists tend to ignore life-threatening, treatable medical conditions in patients presenting for treatment with schizophrenia. Of patients entering the study, 45% had untreated diabetes, 89% had untreated hyperlipidemias and 62% had untreated hypertension. This study failed to reveal anything of significant importance in the psychopharmacological treatment of schizophrenia, but did expose a woeful standard in the medical management of schizophrenia offered by psychiatrists. Psychiatrists should learn to properly treat diabetes, hyperlipidemia and hypertension when detected. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Australasian Psychiatry is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=34660039 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/10398560701689186 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 465 Subjects: – SubjectFull: Antipsychotic agents Type: general – SubjectFull: Schizophrenia Type: general – SubjectFull: Drug side effects Type: general – SubjectFull: Clinical trials Type: general – SubjectFull: Psychiatrists Type: general – SubjectFull: National Institute of Mental Health (U.S.) Type: general – SubjectFull: United States Type: general Titles: – TitleFull: Clinical implications of the CATIE schizophrenia trials: day-to-day management lessons for Australasian psychiatrists. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Bick, Peter – PersonEntity: Name: NameFull: Knoesen, Natalie – PersonEntity: Name: NameFull: Castle, David IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2007 Type: published Y: 2007 Identifiers: – Type: issn-print Value: 10398562 Numbering: – Type: volume Value: 15 – Type: issue Value: 6 Titles: – TitleFull: Australasian Psychiatry Type: main |
| ResultId | 1 |
