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The Trajectory of Psychological Impact in BRCA1/2 Genetic Testing: Does Time Heal?

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Title: The Trajectory of Psychological Impact in BRCA1/2 Genetic Testing: Does Time Heal?
Authors: Beran, Tammy M., Stanton, Annette L., Kwan, Lorna, Seldon, Joyce, Bower, Julienne E., Vodermaier, Andrea, Ganz, Patricia A.
Source: Annals of Behavioral Medicine. 2008, Vol. 36 Issue 2, p107-116. 10p. 3 Charts, 1 Graph.
Subjects: Human chromosome abnormality diagnosis, BRCA genes, Oncogenes, Quality of life, Breast cancer research, Psychology
Abstract: Most research on adjustment of women undergoing genetic testing for breast cancer susceptibility has not followed women for more than 6 months after result receipt and has not evaluated curvilinear patterns in general and cancer-specific adjustment. This study’s primary goal was to examine the trajectory of psychological status in women at risk for breast and ovarian cancer prior to undergoing genetic testing through 1 year after BRCA1/2 result receipt. Women in the UCLA Familial Cancer Registry completed questionnaires assessing psychological status (i.e., depressive symptoms, negative and positive mood, anxiety, and cancer-related distress) prior to testing and at 1, 6, and 12 months after result receipt. Of 155 women tested, 117 were BRCA1/2− (96 uninformative negative and 21 true negative) and 38 were BRCA1/2+. Linear mixed model analyses revealed a consistent pattern in adjustment indicators, such that the groups did not differ at baseline, but mutation carriers endorsed significantly more depressive symptoms, negative mood, and cancer-specific distress relative to non-mutation carriers at 1 and 6 months after test result receipt (and less positive mood at 6 months only). At 12 months, negative and positive mood returned to baseline levels for mutation carriers, and depressive symptoms approached baseline. At 12 months, the groups differed significantly only on cancer-specific distress, owing to declining distress in non-carriers. Neither having a previous cancer diagnosis nor receiving a true negative versus uninformative negative result predicted reactions to genetic testing. Genetic testing prompted an increase in general and cancer-specific distress for BRCA1/2+ women, which remitted by 1 year after result receipt. [ABSTRACT FROM AUTHOR]
Copyright of Annals of Behavioral Medicine is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: The Trajectory of Psychological Impact in BRCA1/2 Genetic Testing: Does Time Heal?
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  Data: <searchLink fieldCode="AR" term="%22Beran%2C+Tammy+M%2E%22">Beran, Tammy M.</searchLink><br /><searchLink fieldCode="AR" term="%22Stanton%2C+Annette+L%2E%22">Stanton, Annette L.</searchLink><br /><searchLink fieldCode="AR" term="%22Kwan%2C+Lorna%22">Kwan, Lorna</searchLink><br /><searchLink fieldCode="AR" term="%22Seldon%2C+Joyce%22">Seldon, Joyce</searchLink><br /><searchLink fieldCode="AR" term="%22Bower%2C+Julienne+E%2E%22">Bower, Julienne E.</searchLink><br /><searchLink fieldCode="AR" term="%22Vodermaier%2C+Andrea%22">Vodermaier, Andrea</searchLink><br /><searchLink fieldCode="AR" term="%22Ganz%2C+Patricia+A%2E%22">Ganz, Patricia A.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Annals+of+Behavioral+Medicine%22">Annals of Behavioral Medicine</searchLink>. 2008, Vol. 36 Issue 2, p107-116. 10p. 3 Charts, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Human+chromosome+abnormality+diagnosis%22">Human chromosome abnormality diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22BRCA+genes%22">BRCA genes</searchLink><br /><searchLink fieldCode="DE" term="%22Oncogenes%22">Oncogenes</searchLink><br /><searchLink fieldCode="DE" term="%22Quality+of+life%22">Quality of life</searchLink><br /><searchLink fieldCode="DE" term="%22Breast+cancer+research%22">Breast cancer research</searchLink><br /><searchLink fieldCode="DE" term="%22Psychology%22">Psychology</searchLink>
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  Data: Most research on adjustment of women undergoing genetic testing for breast cancer susceptibility has not followed women for more than 6 months after result receipt and has not evaluated curvilinear patterns in general and cancer-specific adjustment. This study’s primary goal was to examine the trajectory of psychological status in women at risk for breast and ovarian cancer prior to undergoing genetic testing through 1 year after BRCA1/2 result receipt. Women in the UCLA Familial Cancer Registry completed questionnaires assessing psychological status (i.e., depressive symptoms, negative and positive mood, anxiety, and cancer-related distress) prior to testing and at 1, 6, and 12 months after result receipt. Of 155 women tested, 117 were BRCA1/2− (96 uninformative negative and 21 true negative) and 38 were BRCA1/2+. Linear mixed model analyses revealed a consistent pattern in adjustment indicators, such that the groups did not differ at baseline, but mutation carriers endorsed significantly more depressive symptoms, negative mood, and cancer-specific distress relative to non-mutation carriers at 1 and 6 months after test result receipt (and less positive mood at 6 months only). At 12 months, negative and positive mood returned to baseline levels for mutation carriers, and depressive symptoms approached baseline. At 12 months, the groups differed significantly only on cancer-specific distress, owing to declining distress in non-carriers. Neither having a previous cancer diagnosis nor receiving a true negative versus uninformative negative result predicted reactions to genetic testing. Genetic testing prompted an increase in general and cancer-specific distress for BRCA1/2+ women, which remitted by 1 year after result receipt. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Annals of Behavioral Medicine is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s12160-008-9060-9
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      – SubjectFull: Oncogenes
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              Text: 2008
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