Quetiapine augmentation in depressed patients with partial response to antidepressants.
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| Title: | Quetiapine augmentation in depressed patients with partial response to antidepressants. |
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| Authors: | Olver, James S., Ignatiadis, Sophie, Maruff, Paul, Burrows, Graham D., Norman, Trevor R. |
| Source: | Human Psychopharmacology: Clinical & Experimental. Dec2008, Vol. 23 Issue 8, p653-660. 8p. 3 Charts. |
| Subjects: | Mental depression, Cognition, Antidepressants, Clinical trials, Medical experimentation on humans |
| Abstract: | Objective Clinical trials suggest between 30–50% of depressed patients have an inadequate outcome to antidepressant pharmacotherapy. Among the approaches to improve outcome has been augmentation with antipsychotic medications. We aim to investigate the efficacy and tolerability of augmentation with quetiapine in depressed patients with a partial response to antidepressants. Methods Patients with a Major Depressive Disorder (DSMIV) who had partial/no response to a stable dose of an Selective Serotonin Reuptake Inhibitors (SSRI)/SNRI were recruited. All patients received add-on quetiapine (200–600 mg nocte) in a 6-week trial. Outcome measures (HAMD, MADRS) were assessed at screening, baseline, weeks 1, 2, 4 and 6. Extrapyramidal symptoms (EPSEs) were assessed at baseline, weeks 2, 4 and 6. A neuropsychological battery of tests was administered at baseline, weeks 3 and 6. Results Nineteen patients entered the trial and 18 completed the trial per protocol. We report a rapid improvement in depression ratings over 6 weeks (p < 0.0005) and remission rates of 67% at week 1 and 94% at week 6. There was no evidence of EPSE and no worsening (and some improvement) of cognition. Conclusion This suggests clinical benefits of quetiapine augmentation of SSRI/SNRI antidepressants with no worsening, and possible improvements in cognition. Copyright © 2008 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR] |
| Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 35525499 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Quetiapine augmentation in depressed patients with partial response to antidepressants. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Olver%2C+James+S%2E%22">Olver, James S.</searchLink><br /><searchLink fieldCode="AR" term="%22Ignatiadis%2C+Sophie%22">Ignatiadis, Sophie</searchLink><br /><searchLink fieldCode="AR" term="%22Maruff%2C+Paul%22">Maruff, Paul</searchLink><br /><searchLink fieldCode="AR" term="%22Burrows%2C+Graham+D%2E%22">Burrows, Graham D.</searchLink><br /><searchLink fieldCode="AR" term="%22Norman%2C+Trevor+R%2E%22">Norman, Trevor R.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Human+Psychopharmacology%3A+Clinical+%26+Experimental%22">Human Psychopharmacology: Clinical & Experimental</searchLink>. Dec2008, Vol. 23 Issue 8, p653-660. 8p. 3 Charts. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Cognition%22">Cognition</searchLink><br /><searchLink fieldCode="DE" term="%22Antidepressants%22">Antidepressants</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+trials%22">Clinical trials</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+experimentation+on+humans%22">Medical experimentation on humans</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objective Clinical trials suggest between 30–50% of depressed patients have an inadequate outcome to antidepressant pharmacotherapy. Among the approaches to improve outcome has been augmentation with antipsychotic medications. We aim to investigate the efficacy and tolerability of augmentation with quetiapine in depressed patients with a partial response to antidepressants. Methods Patients with a Major Depressive Disorder (DSMIV) who had partial/no response to a stable dose of an Selective Serotonin Reuptake Inhibitors (SSRI)/SNRI were recruited. All patients received add-on quetiapine (200–600 mg nocte) in a 6-week trial. Outcome measures (HAMD, MADRS) were assessed at screening, baseline, weeks 1, 2, 4 and 6. Extrapyramidal symptoms (EPSEs) were assessed at baseline, weeks 2, 4 and 6. A neuropsychological battery of tests was administered at baseline, weeks 3 and 6. Results Nineteen patients entered the trial and 18 completed the trial per protocol. We report a rapid improvement in depression ratings over 6 weeks (p < 0.0005) and remission rates of 67% at week 1 and 94% at week 6. There was no evidence of EPSE and no worsening (and some improvement) of cognition. Conclusion This suggests clinical benefits of quetiapine augmentation of SSRI/SNRI antidepressants with no worsening, and possible improvements in cognition. Copyright © 2008 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Human Psychopharmacology: Clinical & Experimental is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/hup.970 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 653 Subjects: – SubjectFull: Mental depression Type: general – SubjectFull: Cognition Type: general – SubjectFull: Antidepressants Type: general – SubjectFull: Clinical trials Type: general – SubjectFull: Medical experimentation on humans Type: general Titles: – TitleFull: Quetiapine augmentation in depressed patients with partial response to antidepressants. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Olver, James S. – PersonEntity: Name: NameFull: Ignatiadis, Sophie – PersonEntity: Name: NameFull: Maruff, Paul – PersonEntity: Name: NameFull: Burrows, Graham D. – PersonEntity: Name: NameFull: Norman, Trevor R. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2008 Type: published Y: 2008 Identifiers: – Type: issn-print Value: 08856222 Numbering: – Type: volume Value: 23 – Type: issue Value: 8 Titles: – TitleFull: Human Psychopharmacology: Clinical & Experimental Type: main |
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