Continuous expression of corticotropin-releasing factor in the central nucleus of the amygdala emulates the dysregulation of the stress and reproductive axes.
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| Title: | Continuous expression of corticotropin-releasing factor in the central nucleus of the amygdala emulates the dysregulation of the stress and reproductive axes. |
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| Authors: | Keen-Rhinehart, E., Michopoulos, V., Toufexis, D. J., Martin, E. I., Nair, H., Ressler, K. J., Davis, M., Owens, M. J., Nemeroff, C. B., Wilson, M. E. |
| Source: | Molecular Psychiatry. Jan2009, Vol. 14 Issue 1, p37-50. 14p. 1 Diagram, 7 Graphs. |
| Subjects: | Corticotropin releasing hormone, Psychological stress, Mental health, Progestational hormones, Pituitary hormones |
| Abstract: | An increase in corticotropin-releasing factor (CRF) is a putative factor in the pathophysiology of stress-related disorders. As CRF expression in the central nucleus of the amygdala (CeA) is important in adaptation to chronic stress, we hypothesized that unrestrained synthesis of CRF in CeA would mimic the consequences of chronic stress exposure and cause dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis, increase emotionality and disrupt reproduction. To test this hypothesis, we used a lentiviral vector to increase CRF-expression site specifically in CeA of female rats. Increased synthesis of CRF in CeA amplified CRF and arginine vasopressin peptide concentration in the paraventricular nucleus of the hypothalamus, and decreased glucocorticoid negative feedback, both markers associated with the pathophysiology of depression. In addition, continuous expression of CRF in CeA also increased the acoustic startle response and depressive-like behavior in the forced swim test. Protein levels of gonadotropin-releasing hormone in the medial preoptic area were significantly reduced by continuous expression of CRF in CeA and this was associated with a lengthening of estrous cycles. Finally, sexual motivation but not sexual receptivity was significantly attenuated by continuous CRF synthesis in ovariectomized estradiol-progesterone-primed females. These data indicate that unrestrained CRF synthesis in CeA produces a dysregulation of the HPA axis, as well as many of the behavioral, physiological and reproductive consequences associated with stress-related disorders.Molecular Psychiatry (2009) 14, 37–50; doi:10.1038/mp.2008.91; published online 12 August 2008 [ABSTRACT FROM AUTHOR] |
| Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 35807005 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Continuous expression of corticotropin-releasing factor in the central nucleus of the amygdala emulates the dysregulation of the stress and reproductive axes. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Keen-Rhinehart%2C+E%2E%22">Keen-Rhinehart, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Michopoulos%2C+V%2E%22">Michopoulos, V.</searchLink><br /><searchLink fieldCode="AR" term="%22Toufexis%2C+D%2E+J%2E%22">Toufexis, D. J.</searchLink><br /><searchLink fieldCode="AR" term="%22Martin%2C+E%2E+I%2E%22">Martin, E. I.</searchLink><br /><searchLink fieldCode="AR" term="%22Nair%2C+H%2E%22">Nair, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Ressler%2C+K%2E+J%2E%22">Ressler, K. J.</searchLink><br /><searchLink fieldCode="AR" term="%22Davis%2C+M%2E%22">Davis, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Owens%2C+M%2E+J%2E%22">Owens, M. J.</searchLink><br /><searchLink fieldCode="AR" term="%22Nemeroff%2C+C%2E+B%2E%22">Nemeroff, C. B.</searchLink><br /><searchLink fieldCode="AR" term="%22Wilson%2C+M%2E+E%2E%22">Wilson, M. E.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Molecular+Psychiatry%22">Molecular Psychiatry</searchLink>. Jan2009, Vol. 14 Issue 1, p37-50. 14p. 1 Diagram, 7 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Corticotropin+releasing+hormone%22">Corticotropin releasing hormone</searchLink><br /><searchLink fieldCode="DE" term="%22Psychological+stress%22">Psychological stress</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+health%22">Mental health</searchLink><br /><searchLink fieldCode="DE" term="%22Progestational+hormones%22">Progestational hormones</searchLink><br /><searchLink fieldCode="DE" term="%22Pituitary+hormones%22">Pituitary hormones</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: An increase in corticotropin-releasing factor (CRF) is a putative factor in the pathophysiology of stress-related disorders. As CRF expression in the central nucleus of the amygdala (CeA) is important in adaptation to chronic stress, we hypothesized that unrestrained synthesis of CRF in CeA would mimic the consequences of chronic stress exposure and cause dysregulation of the hypothalamic–pituitary–adrenal (HPA) axis, increase emotionality and disrupt reproduction. To test this hypothesis, we used a lentiviral vector to increase CRF-expression site specifically in CeA of female rats. Increased synthesis of CRF in CeA amplified CRF and arginine vasopressin peptide concentration in the paraventricular nucleus of the hypothalamus, and decreased glucocorticoid negative feedback, both markers associated with the pathophysiology of depression. In addition, continuous expression of CRF in CeA also increased the acoustic startle response and depressive-like behavior in the forced swim test. Protein levels of gonadotropin-releasing hormone in the medial preoptic area were significantly reduced by continuous expression of CRF in CeA and this was associated with a lengthening of estrous cycles. Finally, sexual motivation but not sexual receptivity was significantly attenuated by continuous CRF synthesis in ovariectomized estradiol-progesterone-primed females. These data indicate that unrestrained CRF synthesis in CeA produces a dysregulation of the HPA axis, as well as many of the behavioral, physiological and reproductive consequences associated with stress-related disorders.Molecular Psychiatry (2009) 14, 37–50; doi:10.1038/mp.2008.91; published online 12 August 2008 [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/mp.2008.91 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 37 Subjects: – SubjectFull: Corticotropin releasing hormone Type: general – SubjectFull: Psychological stress Type: general – SubjectFull: Mental health Type: general – SubjectFull: Progestational hormones Type: general – SubjectFull: Pituitary hormones Type: general Titles: – TitleFull: Continuous expression of corticotropin-releasing factor in the central nucleus of the amygdala emulates the dysregulation of the stress and reproductive axes. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Keen-Rhinehart, E. – PersonEntity: Name: NameFull: Michopoulos, V. – PersonEntity: Name: NameFull: Toufexis, D. J. – PersonEntity: Name: NameFull: Martin, E. I. – PersonEntity: Name: NameFull: Nair, H. – PersonEntity: Name: NameFull: Ressler, K. J. – PersonEntity: Name: NameFull: Davis, M. – PersonEntity: Name: NameFull: Owens, M. J. – PersonEntity: Name: NameFull: Nemeroff, C. B. – PersonEntity: Name: NameFull: Wilson, M. E. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2009 Type: published Y: 2009 Identifiers: – Type: issn-print Value: 13594184 Numbering: – Type: volume Value: 14 – Type: issue Value: 1 Titles: – TitleFull: Molecular Psychiatry Type: main |
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