Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low, anxiety: possible key role of placental 11β-hydroxysteroid dehydrogenase type 2.
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| Title: | Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low, anxiety: possible key role of placental 11β-hydroxysteroid dehydrogenase type 2. |
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| Authors: | Lucassen, P. J. (AUTHOR), Bosch, O. J. (AUTHOR), Jousma, E. (AUTHOR), Krömer, S. A. (AUTHOR), Andrew, R. (AUTHOR), Seckl, J. R. (AUTHOR), Neumann, I. D. (AUTHOR) |
| Source: | European Journal of Neuroscience. Jan2009, Vol. 29 Issue 1, p97-103. 7p. 1 Diagram, 1 Chart, 1 Graph. |
| Subjects: | Developmental neurobiology, Anxiety, Dehydrogenases, Hippocampus (Brain), Genetics |
| Abstract: | Prenatal stress (PS) produces persistent abnormalities in anxiety-related behaviors, stress responsivity, susceptibility to psychopathology and hippocampal changes in adult offspring. The hippocampus shows a remarkable degree of structural plasticity, notably in response to stress and glucocorticoids. We hypothesized that PS would differentially affect hippocampal neurogenesis in rats selectively bred for genetic differences in anxiety-related behaviors and stress responsivity. Pregnant dams of high anxiety-related behavior (HAB) and low anxiety-related behavior (LAB) strains were stressed between days 5 and 20 of pregnancy. The survival of newly generated hippocampal cells was found to be significantly lower in 43-day-old HAB than in LAB male offspring of unstressed pregnancies. PS further reduced newly generated cell numbers only in HAB rats, and this was paralleled by a reduction in doublecortin-positive cell numbers, indicative of reduced neurogenesis. As maternal plasma corticosterone levels during PS were similar in both strains, we examined placental 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which catalyses rapid inactivation of maternal corticosterone to inert 11-dehydrocorticosterone and thus serves as a physiological ‘barrier’ to maternal glucocorticoids. PS significantly increased placental 11β-HSD2 activity in LAB, but not HAB, rats. We conclude that PS differentially affects the number of surviving newly generated cells and neurogenesis in HAB and LAB rats. The high sensitivity of hippocampal neurogenesis to PS in HAB rats is paralleled by a failure to increase placental 11β-HSD2 activity after stress rather than by different maternal corticosterone responses. Hence, stress-induced placental 11β-HSD2 expression may be critical in protecting the fetal brain from maternal stress-induced effects on adult neurogenesis. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 35818417 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low, anxiety: possible key role of placental 11β-hydroxysteroid dehydrogenase type 2. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Lucassen%2C+P%2E+J%2E%22">Lucassen, P. J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bosch%2C+O%2E+J%2E%22">Bosch, O. J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jousma%2C+E%2E%22">Jousma, E.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Krömer%2C+S%2E+A%2E%22">Krömer, S. A.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Andrew%2C+R%2E%22">Andrew, R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Seckl%2C+J%2E+R%2E%22">Seckl, J. R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Neumann%2C+I%2E+D%2E%22">Neumann, I. D.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Jan2009, Vol. 29 Issue 1, p97-103. 7p. 1 Diagram, 1 Chart, 1 Graph. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Developmental+neurobiology%22">Developmental neurobiology</searchLink><br /><searchLink fieldCode="DE" term="%22Anxiety%22">Anxiety</searchLink><br /><searchLink fieldCode="DE" term="%22Dehydrogenases%22">Dehydrogenases</searchLink><br /><searchLink fieldCode="DE" term="%22Hippocampus+%28Brain%29%22">Hippocampus (Brain)</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Prenatal stress (PS) produces persistent abnormalities in anxiety-related behaviors, stress responsivity, susceptibility to psychopathology and hippocampal changes in adult offspring. The hippocampus shows a remarkable degree of structural plasticity, notably in response to stress and glucocorticoids. We hypothesized that PS would differentially affect hippocampal neurogenesis in rats selectively bred for genetic differences in anxiety-related behaviors and stress responsivity. Pregnant dams of high anxiety-related behavior (HAB) and low anxiety-related behavior (LAB) strains were stressed between days 5 and 20 of pregnancy. The survival of newly generated hippocampal cells was found to be significantly lower in 43-day-old HAB than in LAB male offspring of unstressed pregnancies. PS further reduced newly generated cell numbers only in HAB rats, and this was paralleled by a reduction in doublecortin-positive cell numbers, indicative of reduced neurogenesis. As maternal plasma corticosterone levels during PS were similar in both strains, we examined placental 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2), which catalyses rapid inactivation of maternal corticosterone to inert 11-dehydrocorticosterone and thus serves as a physiological ‘barrier’ to maternal glucocorticoids. PS significantly increased placental 11β-HSD2 activity in LAB, but not HAB, rats. We conclude that PS differentially affects the number of surviving newly generated cells and neurogenesis in HAB and LAB rats. The high sensitivity of hippocampal neurogenesis to PS in HAB rats is paralleled by a failure to increase placental 11β-HSD2 activity after stress rather than by different maternal corticosterone responses. Hence, stress-induced placental 11β-HSD2 expression may be critical in protecting the fetal brain from maternal stress-induced effects on adult neurogenesis. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/j.1460-9568.2008.06543.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 97 Subjects: – SubjectFull: Developmental neurobiology Type: general – SubjectFull: Anxiety Type: general – SubjectFull: Dehydrogenases Type: general – SubjectFull: Hippocampus (Brain) Type: general – SubjectFull: Genetics Type: general Titles: – TitleFull: Prenatal stress reduces postnatal neurogenesis in rats selectively bred for high, but not low, anxiety: possible key role of placental 11β-hydroxysteroid dehydrogenase type 2. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lucassen, P. J. – PersonEntity: Name: NameFull: Bosch, O. J. – PersonEntity: Name: NameFull: Jousma, E. – PersonEntity: Name: NameFull: Krömer, S. A. – PersonEntity: Name: NameFull: Andrew, R. – PersonEntity: Name: NameFull: Seckl, J. R. – PersonEntity: Name: NameFull: Neumann, I. D. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan2009 Type: published Y: 2009 Identifiers: – Type: issn-print Value: 0953816X Numbering: – Type: volume Value: 29 – Type: issue Value: 1 Titles: – TitleFull: European Journal of Neuroscience Type: main |
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