View in EDS HTML Full Text PDF Full Text

A Preliminary Trial: Double-Blind Comparison of Nefazodone, Bupropion-SR, and Placebo in the Treatment of Cannabis Dependence.

Saved in:
Bibliographic Details
Title: A Preliminary Trial: Double-Blind Comparison of Nefazodone, Bupropion-SR, and Placebo in the Treatment of Cannabis Dependence.
Authors: Carpenter, Kenneth M. (AUTHOR), McDowell, David (AUTHOR), Brooks, Daniel J. (AUTHOR), Cheng, Wendy Y. (AUTHOR), Levin, Frances R. (AUTHOR)
Source: American Journal on Addictions. Jan/Feb2009, Vol. 18 Issue 1, p53-64. 12p. 1 Diagram, 4 Charts.
Subjects: Antidepressants, Clinical trials, Marijuana abuse, Placebos, Drug withdrawal symptoms, Cannabis (Genus), Treatment of drug addiction, Clinical medicine research, Smokable plants
Abstract: The present study investigated the efficacy of nefazodone and bupropion-sustained release for treating cannabis dependence. A double-blind, placebo-controlled, piggy back design was employed to assess if nefazodone and bupropion-sustained release increased the probability of abstinence from cannabis and reduced the severity of cannabis dependence and cannabis withdrawal symptoms during a 13-week outpatient treatment program. One-hundred and six participants (Mean = 32 years; females n = 25) were randomized to one of three medication conditions (nefazodone, bupropion-sustained release, or placebo) and participated in a weekly, individually based coping skills therapy program. Results indicated an increased probability of achieving abstinence over the course of treatment and a decrease in the severity of cannabis dependence and the withdrawal symptom of irritability. There were no significant effects demonstrated for nefazodone and bupropion-sustained release on cannabis use or cannabis withdrawal symptoms. The results indicate nefazodone and bupropion-sustained release may have limited efficacy in treating cannabis dependence. [ABSTRACT FROM AUTHOR]
Copyright of American Journal on Addictions is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 36504712
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: A Preliminary Trial: Double-Blind Comparison of Nefazodone, Bupropion-SR, and Placebo in the Treatment of Cannabis Dependence.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Carpenter%2C+Kenneth+M%2E%22">Carpenter, Kenneth M.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22McDowell%2C+David%22">McDowell, David</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Brooks%2C+Daniel+J%2E%22">Brooks, Daniel J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cheng%2C+Wendy+Y%2E%22">Cheng, Wendy Y.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Levin%2C+Frances+R%2E%22">Levin, Frances R.</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22American+Journal+on+Addictions%22">American Journal on Addictions</searchLink>. Jan/Feb2009, Vol. 18 Issue 1, p53-64. 12p. 1 Diagram, 4 Charts.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Antidepressants%22">Antidepressants</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+trials%22">Clinical trials</searchLink><br /><searchLink fieldCode="DE" term="%22Marijuana+abuse%22">Marijuana abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Placebos%22">Placebos</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+withdrawal+symptoms%22">Drug withdrawal symptoms</searchLink><br /><searchLink fieldCode="DE" term="%22Cannabis+%28Genus%29%22">Cannabis (Genus)</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+of+drug+addiction%22">Treatment of drug addiction</searchLink><br /><searchLink fieldCode="DE" term="%22Clinical+medicine+research%22">Clinical medicine research</searchLink><br /><searchLink fieldCode="DE" term="%22Smokable+plants%22">Smokable plants</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The present study investigated the efficacy of nefazodone and bupropion-sustained release for treating cannabis dependence. A double-blind, placebo-controlled, piggy back design was employed to assess if nefazodone and bupropion-sustained release increased the probability of abstinence from cannabis and reduced the severity of cannabis dependence and cannabis withdrawal symptoms during a 13-week outpatient treatment program. One-hundred and six participants (Mean = 32 years; females n = 25) were randomized to one of three medication conditions (nefazodone, bupropion-sustained release, or placebo) and participated in a weekly, individually based coping skills therapy program. Results indicated an increased probability of achieving abstinence over the course of treatment and a decrease in the severity of cannabis dependence and the withdrawal symptom of irritability. There were no significant effects demonstrated for nefazodone and bupropion-sustained release on cannabis use or cannabis withdrawal symptoms. The results indicate nefazodone and bupropion-sustained release may have limited efficacy in treating cannabis dependence. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of American Journal on Addictions is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=36504712
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/10550490802408936
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 12
        StartPage: 53
    Subjects:
      – SubjectFull: Antidepressants
        Type: general
      – SubjectFull: Clinical trials
        Type: general
      – SubjectFull: Marijuana abuse
        Type: general
      – SubjectFull: Placebos
        Type: general
      – SubjectFull: Drug withdrawal symptoms
        Type: general
      – SubjectFull: Cannabis (Genus)
        Type: general
      – SubjectFull: Treatment of drug addiction
        Type: general
      – SubjectFull: Clinical medicine research
        Type: general
      – SubjectFull: Smokable plants
        Type: general
    Titles:
      – TitleFull: A Preliminary Trial: Double-Blind Comparison of Nefazodone, Bupropion-SR, and Placebo in the Treatment of Cannabis Dependence.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Carpenter, Kenneth M.
      – PersonEntity:
          Name:
            NameFull: McDowell, David
      – PersonEntity:
          Name:
            NameFull: Brooks, Daniel J.
      – PersonEntity:
          Name:
            NameFull: Cheng, Wendy Y.
      – PersonEntity:
          Name:
            NameFull: Levin, Frances R.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Text: Jan/Feb2009
              Type: published
              Y: 2009
          Identifiers:
            – Type: issn-print
              Value: 10550496
          Numbering:
            – Type: volume
              Value: 18
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: American Journal on Addictions
              Type: main
ResultId 1