Absence of Histological Changes after the Administration of a Continuous Intrathecal Clonidine in Wistar rats.
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| Title: | Absence of Histological Changes after the Administration of a Continuous Intrathecal Clonidine in Wistar rats. |
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| Authors: | Guevara-López, Uriah, Aldrete, J. Antonio, Covarrubias-Gómez, Alfredo, Hernández-Pando, Rogelio E., López-Muñoz, Francisco J. |
| Source: | Pain Practice. Mar/Apr2009, Vol. 9 Issue 2, p122-129. 8p. 1 Black and White Photograph, 1 Diagram, 2 Charts. |
| Subjects: | Clonidine, Antihypertensive agents, Rats, Pain management, Chronic pain, Immunological adjuvants |
| Abstract: | Background: The administration of epidural and spinal clonidine has demonstrated an antinociceptive effect in animals and humans. For that reason, its spinal administration has been proposed as an adjuvant in chronic pain management. However, there is limited information about its possible neurotoxic effect after its continuous neuraxial administration. Method: Twelve male Wistar rats were randomly divided into two groups. Using an osmotic mini-pump a continuous infusion of intrathecal clonidine, (21.4 micrograms/day, Group A) or saline solution (Group B), was administered for 14 consecutive days. For evaluating the neurological damage a neuropathological analysis of the spinal cord was performed by light microscopy. Results: Neurohistopathologic examination of the spinal cord specimens failed to show evidence of neurotoxic damage in either group. Conclusions: These findings showed that continuous intrathecal administration of clonidine did not produce evidence of histological neurotoxicity; therefore it is possible that continuous administration of intrathecal clonidine might be a safe option for treatment of chronic intractable pain; however, further investigations are necessary for evaluating diverse doses and periods of time, and to define its possible behavioral effects. [ABSTRACT FROM AUTHOR] |
| Copyright of Pain Practice is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 36606231 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Absence of Histological Changes after the Administration of a Continuous Intrathecal Clonidine in Wistar rats. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Guevara-López%2C+Uriah%22">Guevara-López, Uriah</searchLink><br /><searchLink fieldCode="AR" term="%22Aldrete%2C+J%2E+Antonio%22">Aldrete, J. Antonio</searchLink><br /><searchLink fieldCode="AR" term="%22Covarrubias-Gómez%2C+Alfredo%22">Covarrubias-Gómez, Alfredo</searchLink><br /><searchLink fieldCode="AR" term="%22Hernández-Pando%2C+Rogelio+E%2E%22">Hernández-Pando, Rogelio E.</searchLink><br /><searchLink fieldCode="AR" term="%22López-Muñoz%2C+Francisco+J%2E%22">López-Muñoz, Francisco J.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Pain+Practice%22">Pain Practice</searchLink>. Mar/Apr2009, Vol. 9 Issue 2, p122-129. 8p. 1 Black and White Photograph, 1 Diagram, 2 Charts. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Clonidine%22">Clonidine</searchLink><br /><searchLink fieldCode="DE" term="%22Antihypertensive+agents%22">Antihypertensive agents</searchLink><br /><searchLink fieldCode="DE" term="%22Rats%22">Rats</searchLink><br /><searchLink fieldCode="DE" term="%22Pain+management%22">Pain management</searchLink><br /><searchLink fieldCode="DE" term="%22Chronic+pain%22">Chronic pain</searchLink><br /><searchLink fieldCode="DE" term="%22Immunological+adjuvants%22">Immunological adjuvants</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: The administration of epidural and spinal clonidine has demonstrated an antinociceptive effect in animals and humans. For that reason, its spinal administration has been proposed as an adjuvant in chronic pain management. However, there is limited information about its possible neurotoxic effect after its continuous neuraxial administration. Method: Twelve male Wistar rats were randomly divided into two groups. Using an osmotic mini-pump a continuous infusion of intrathecal clonidine, (21.4 micrograms/day, Group A) or saline solution (Group B), was administered for 14 consecutive days. For evaluating the neurological damage a neuropathological analysis of the spinal cord was performed by light microscopy. Results: Neurohistopathologic examination of the spinal cord specimens failed to show evidence of neurotoxic damage in either group. Conclusions: These findings showed that continuous intrathecal administration of clonidine did not produce evidence of histological neurotoxicity; therefore it is possible that continuous administration of intrathecal clonidine might be a safe option for treatment of chronic intractable pain; however, further investigations are necessary for evaluating diverse doses and periods of time, and to define its possible behavioral effects. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Pain Practice is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/j.1533-2500.2008.00251.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 122 Subjects: – SubjectFull: Clonidine Type: general – SubjectFull: Antihypertensive agents Type: general – SubjectFull: Rats Type: general – SubjectFull: Pain management Type: general – SubjectFull: Chronic pain Type: general – SubjectFull: Immunological adjuvants Type: general Titles: – TitleFull: Absence of Histological Changes after the Administration of a Continuous Intrathecal Clonidine in Wistar rats. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Guevara-López, Uriah – PersonEntity: Name: NameFull: Aldrete, J. Antonio – PersonEntity: Name: NameFull: Covarrubias-Gómez, Alfredo – PersonEntity: Name: NameFull: Hernández-Pando, Rogelio E. – PersonEntity: Name: NameFull: López-Muñoz, Francisco J. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar/Apr2009 Type: published Y: 2009 Identifiers: – Type: issn-print Value: 15307085 Numbering: – Type: volume Value: 9 – Type: issue Value: 2 Titles: – TitleFull: Pain Practice Type: main |
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