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Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomised, double-blind, placebo-controlled trial.

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Title: Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomised, double-blind, placebo-controlled trial.
Authors: Bussel, James B., Provan, Drew, Shamsi, Tahir, Cheng, Gregory, Psaila, Bethan, Kavaleva, Lidia, Salama, Abdulgabar, Jenkins, Julian M., Roychowdhury, Debasish, Mayer, Bhabita, Stone, Nicole, Arning, Michael
Source: Lancet. 2/21/2009, Vol. 373 Issue 9664, p641-648. 8p. 3 Graphs.
Subjects: Randomized controlled trials, Medical research, Thrombotic thrombocytopenic purpura, Blood platelets, Drug efficacy, Hemorrhage
Abstract: The article presents a randomised, controlled study which assessed the efficacy, safety, and tolerability of eltrombopag on platelet counts and bleeding during the treatment of chronic idiopathic thrombocytopenic purpura (ITP). The efficacy of a dose increase to 75 mg was also examined. Adults with platelet counts less than 30,000 per µL of blood and one or more previous ITP treatments received standard care plus eltrombopag 50 mg once a day or placebo for up to six weeks. After three weeks, patients with platelet counts less than 50,000 per µL could increase dosage to 75 mg. Researchers found that eltrombopag is an effective treatment for managing thrombocytopenia in chronic ITP.
Database: Psychology and Behavioral Sciences Collection
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DbLabel: Psychology and Behavioral Sciences Collection
An: 36649653
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomised, double-blind, placebo-controlled trial.
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  Data: <searchLink fieldCode="AR" term="%22Bussel%2C+James+B%2E%22">Bussel, James B.</searchLink><br /><searchLink fieldCode="AR" term="%22Provan%2C+Drew%22">Provan, Drew</searchLink><br /><searchLink fieldCode="AR" term="%22Shamsi%2C+Tahir%22">Shamsi, Tahir</searchLink><br /><searchLink fieldCode="AR" term="%22Cheng%2C+Gregory%22">Cheng, Gregory</searchLink><br /><searchLink fieldCode="AR" term="%22Psaila%2C+Bethan%22">Psaila, Bethan</searchLink><br /><searchLink fieldCode="AR" term="%22Kavaleva%2C+Lidia%22">Kavaleva, Lidia</searchLink><br /><searchLink fieldCode="AR" term="%22Salama%2C+Abdulgabar%22">Salama, Abdulgabar</searchLink><br /><searchLink fieldCode="AR" term="%22Jenkins%2C+Julian+M%2E%22">Jenkins, Julian M.</searchLink><br /><searchLink fieldCode="AR" term="%22Roychowdhury%2C+Debasish%22">Roychowdhury, Debasish</searchLink><br /><searchLink fieldCode="AR" term="%22Mayer%2C+Bhabita%22">Mayer, Bhabita</searchLink><br /><searchLink fieldCode="AR" term="%22Stone%2C+Nicole%22">Stone, Nicole</searchLink><br /><searchLink fieldCode="AR" term="%22Arning%2C+Michael%22">Arning, Michael</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 2/21/2009, Vol. 373 Issue 9664, p641-648. 8p. 3 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Randomized+controlled+trials%22">Randomized controlled trials</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+research%22">Medical research</searchLink><br /><searchLink fieldCode="DE" term="%22Thrombotic+thrombocytopenic+purpura%22">Thrombotic thrombocytopenic purpura</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+platelets%22">Blood platelets</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+efficacy%22">Drug efficacy</searchLink><br /><searchLink fieldCode="DE" term="%22Hemorrhage%22">Hemorrhage</searchLink>
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  Data: The article presents a randomised, controlled study which assessed the efficacy, safety, and tolerability of eltrombopag on platelet counts and bleeding during the treatment of chronic idiopathic thrombocytopenic purpura (ITP). The efficacy of a dose increase to 75 mg was also examined. Adults with platelet counts less than 30,000 per µL of blood and one or more previous ITP treatments received standard care plus eltrombopag 50 mg once a day or placebo for up to six weeks. After three weeks, patients with platelet counts less than 50,000 per µL could increase dosage to 75 mg. Researchers found that eltrombopag is an effective treatment for managing thrombocytopenia in chronic ITP.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=36649653
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      – Type: doi
        Value: 10.1016/S0140-6736(09)60402-5
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      – Code: eng
        Text: English
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      – SubjectFull: Medical research
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      – SubjectFull: Thrombotic thrombocytopenic purpura
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      – SubjectFull: Blood platelets
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      – SubjectFull: Drug efficacy
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              Text: 2/21/2009
              Type: published
              Y: 2009
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