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Asymmetrical lateral ventricular enlargement in Parkinson’s disease.

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Title: Asymmetrical lateral ventricular enlargement in Parkinson’s disease.
Authors: Lewis, M. M., Smith, A. B., Styner, M., Gu, H., Poole, R., Zhu, H., Li, Y., Barbero, X., Gouttard, S., McKeown, M. J., Mailman, R. B., Huang, X.
Source: European Journal of Neurology. Apr2009, Vol. 16 Issue 4, p475-481. 7p. 2 Charts, 2 Graphs.
Subjects: Parkinson's disease, Heart dilatation, Brain diseases, Motor ability, Magnetic resonance imaging
Abstract: Background: A recent case report suggested the presence of asymmetrical lateral ventricular enlargement associated with motor asymmetry in Parkinson’s disease (PD). The current study explored these associations further. Methods: Magnetic resonance imaging (3T) scans were obtained on 17 PD and 15 healthy control subjects at baseline and 12–43 months later. Baseline and longitudinal lateral ventricular volumetric changes were compared between contralateral and ipsilateral ventricles in PD subjects relative to symptom onset side and in controls relative to their dominant hand. Correlations between changes in ventricular volume and United Parkinson’s disease rating scale motor scores (UPDRS-III) whilst on medication were determined. Results: The lateral ventricle contralateral to symptom onset side displayed a faster rate of enlargement compared to the ipsilateral ( P = 0.004) in PD subjects, with no such asymmetry detected ( P = 0.312) in controls. There was a positive correlation between ventricular enlargement and worsening motor function assessed by UPDRS-III scores ( r = 0.96, P < 0.001). Discussion: There is asymmetrical lateral ventricular enlargement that is associated with PD motor asymmetry and progression. Further studies are warranted to investigate the underlying mechanism(s), as well as the potential of using volumetric measurements as a marker for PD progression. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Asymmetrical lateral ventricular enlargement in Parkinson’s disease.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lewis%2C+M%2E+M%2E%22&quot;&gt;Lewis, M. M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Smith%2C+A%2E+B%2E%22&quot;&gt;Smith, A. B.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Styner%2C+M%2E%22&quot;&gt;Styner, M.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gu%2C+H%2E%22&quot;&gt;Gu, H.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Poole%2C+R%2E%22&quot;&gt;Poole, R.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Zhu%2C+H%2E%22&quot;&gt;Zhu, H.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Li%2C+Y%2E%22&quot;&gt;Li, Y.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Barbero%2C+X%2E%22&quot;&gt;Barbero, X.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gouttard%2C+S%2E%22&quot;&gt;Gouttard, S.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22McKeown%2C+M%2E+J%2E%22&quot;&gt;McKeown, M. J.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Mailman%2C+R%2E+B%2E%22&quot;&gt;Mailman, R. B.&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Huang%2C+X%2E%22&quot;&gt;Huang, X.&lt;/searchLink&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Journal+of+Neurology%22&quot;&gt;European Journal of Neurology&lt;/searchLink&gt;. Apr2009, Vol. 16 Issue 4, p475-481. 7p. 2 Charts, 2 Graphs.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Parkinson&#39;s+disease%22&quot;&gt;Parkinson&#39;s disease&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Heart+dilatation%22&quot;&gt;Heart dilatation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Brain+diseases%22&quot;&gt;Brain diseases&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Motor+ability%22&quot;&gt;Motor ability&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Magnetic+resonance+imaging%22&quot;&gt;Magnetic resonance imaging&lt;/searchLink&gt;
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  Data: Background: A recent case report suggested the presence of asymmetrical lateral ventricular enlargement associated with motor asymmetry in Parkinson’s disease (PD). The current study explored these associations further. Methods: Magnetic resonance imaging (3T) scans were obtained on 17 PD and 15 healthy control subjects at baseline and 12–43 months later. Baseline and longitudinal lateral ventricular volumetric changes were compared between contralateral and ipsilateral ventricles in PD subjects relative to symptom onset side and in controls relative to their dominant hand. Correlations between changes in ventricular volume and United Parkinson’s disease rating scale motor scores (UPDRS-III) whilst on medication were determined. Results: The lateral ventricle contralateral to symptom onset side displayed a faster rate of enlargement compared to the ipsilateral ( P = 0.004) in PD subjects, with no such asymmetry detected ( P = 0.312) in controls. There was a positive correlation between ventricular enlargement and worsening motor function assessed by UPDRS-III scores ( r = 0.96, P &lt; 0.001). Discussion: There is asymmetrical lateral ventricular enlargement that is associated with PD motor asymmetry and progression. Further studies are warranted to investigate the underlying mechanism(s), as well as the potential of using volumetric measurements as a marker for PD progression. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=36998649
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