View in EDS PDF Full Text

Nuclear Hormone Receptor Regulation of MicroRNAs Controls Developmental Progression.

Saved in:
Bibliographic Details
Title: Nuclear Hormone Receptor Regulation of MicroRNAs Controls Developmental Progression.
Authors: Bethke, Axel (AUTHOR), Fielenbach, Nicole (AUTHOR), Zhu Wang (AUTHOR), Mangelsdorf, David J. (AUTHOR), Antebi, Adam (AUTHOR)
Source: Science (pre-March 2025). 4/3/2009, Vol. 324 Issue 5923, p95-98. 4p.
Subjects: Hormone receptors, Retinoids, Steroids, Gene expression, Genetic regulation, Messenger RNA, Caenorhabditis elegans
Abstract: In response to small-molecule signals such as retinoids or steroids, nuclear receptors activate gene expression to regulate development in different tissues. MicroRNAs turn off target gene expression within cells by binding complementary regions in messenger RNA transcripts, and they have been broadly implicated in development and disease. Here we show that the Caenorhabditis elegans nuclear receptor DAF-12 and its steroidal ligand directly activate promoters of let-7 microRNA family members to down-regulate the microRNA target hbl-1, which drives progression of epidermal stem cells from second to third larval stage patterns of cell division. Conversely, the receptor without the ligand represses microRNA expression during developmental arrest. These findings identify microRNAs as components of a hormone-coupled molecular switch that shuts off earlier developmental programs to allow for later ones. [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 38121335
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Nuclear Hormone Receptor Regulation of MicroRNAs Controls Developmental Progression.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Bethke%2C+Axel%22">Bethke, Axel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fielenbach%2C+Nicole%22">Fielenbach, Nicole</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhu+Wang%22">Zhu Wang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mangelsdorf%2C+David+J%2E%22">Mangelsdorf, David J.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Antebi%2C+Adam%22">Antebi, Adam</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 4/3/2009, Vol. 324 Issue 5923, p95-98. 4p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Hormone+receptors%22">Hormone receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Retinoids%22">Retinoids</searchLink><br /><searchLink fieldCode="DE" term="%22Steroids%22">Steroids</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+regulation%22">Genetic regulation</searchLink><br /><searchLink fieldCode="DE" term="%22Messenger+RNA%22">Messenger RNA</searchLink><br /><searchLink fieldCode="DE" term="%22Caenorhabditis+elegans%22">Caenorhabditis elegans</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: In response to small-molecule signals such as retinoids or steroids, nuclear receptors activate gene expression to regulate development in different tissues. MicroRNAs turn off target gene expression within cells by binding complementary regions in messenger RNA transcripts, and they have been broadly implicated in development and disease. Here we show that the Caenorhabditis elegans nuclear receptor DAF-12 and its steroidal ligand directly activate promoters of let-7 microRNA family members to down-regulate the microRNA target hbl-1, which drives progression of epidermal stem cells from second to third larval stage patterns of cell division. Conversely, the receptor without the ligand represses microRNA expression during developmental arrest. These findings identify microRNAs as components of a hormone-coupled molecular switch that shuts off earlier developmental programs to allow for later ones. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=38121335
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1126/science.1164899
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 4
        StartPage: 95
    Subjects:
      – SubjectFull: Hormone receptors
        Type: general
      – SubjectFull: Retinoids
        Type: general
      – SubjectFull: Steroids
        Type: general
      – SubjectFull: Gene expression
        Type: general
      – SubjectFull: Genetic regulation
        Type: general
      – SubjectFull: Messenger RNA
        Type: general
      – SubjectFull: Caenorhabditis elegans
        Type: general
    Titles:
      – TitleFull: Nuclear Hormone Receptor Regulation of MicroRNAs Controls Developmental Progression.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Bethke, Axel
      – PersonEntity:
          Name:
            NameFull: Fielenbach, Nicole
      – PersonEntity:
          Name:
            NameFull: Zhu Wang
      – PersonEntity:
          Name:
            NameFull: Mangelsdorf, David J.
      – PersonEntity:
          Name:
            NameFull: Antebi, Adam
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 03
              M: 04
              Text: 4/3/2009
              Type: published
              Y: 2009
          Identifiers:
            – Type: issn-print
              Value: 00368075
          Numbering:
            – Type: volume
              Value: 324
            – Type: issue
              Value: 5923
          Titles:
            – TitleFull: Science (pre-March 2025)
              Type: main
ResultId 1