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Hypoinsulinaemia, glucose intolerance and diminished Beta-cell size in S6K1-deficient mice.

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Title: Hypoinsulinaemia, glucose intolerance and diminished Beta-cell size in S6K1-deficient mice.
Authors: Pende, Mario, Kozma, Sara C., Jaquet, Muriel, Oorschot, Viola, Burcelin, Remy, Le Marchand-Brustel, Yannick, Klumperman, Judith, Thorens, Bernard, Thomas, George
Source: Nature. 12/21/2000-12/28/2000, Vol. 408 Issue 6815, p994. 4p. 4 Color Photographs, 3 Black and White Photographs, 9 Graphs.
Subjects: Protein kinases, Insulin, Glucose, Pancreatic beta cells, Diabetes, Metabolism, Diseases
Abstract: Shows that mice deficient for S6 kinase 1, an effector of the phosphatidylinositide-3-OH kinase signalling pathway, are hypoinsulinaemic and glucose intolerant. Reduction in glucose-induced insulin secretion and in pancreatic insulin production which is due to a reduction in pancreatic endocrine mass cuased by a selective decrease in beta-cell size; Parallel between the observed phenotype and preclinical type 2 diabetes mellitus.
Database: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
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  Data: Hypoinsulinaemia, glucose intolerance and diminished Beta-cell size in S6K1-deficient mice.
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  Data: <searchLink fieldCode="JN" term="%22Nature%22">Nature</searchLink>. 12/21/2000-12/28/2000, Vol. 408 Issue 6815, p994. 4p. 4 Color Photographs, 3 Black and White Photographs, 9 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Protein+kinases%22">Protein kinases</searchLink><br /><searchLink fieldCode="DE" term="%22Insulin%22">Insulin</searchLink><br /><searchLink fieldCode="DE" term="%22Glucose%22">Glucose</searchLink><br /><searchLink fieldCode="DE" term="%22Pancreatic+beta+cells%22">Pancreatic beta cells</searchLink><br /><searchLink fieldCode="DE" term="%22Diabetes%22">Diabetes</searchLink><br /><searchLink fieldCode="DE" term="%22Metabolism%22">Metabolism</searchLink><br /><searchLink fieldCode="DE" term="%22Diseases%22">Diseases</searchLink>
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  Data: Shows that mice deficient for S6 kinase 1, an effector of the phosphatidylinositide-3-OH kinase signalling pathway, are hypoinsulinaemic and glucose intolerant. Reduction in glucose-induced insulin secretion and in pancreatic insulin production which is due to a reduction in pancreatic endocrine mass cuased by a selective decrease in beta-cell size; Parallel between the observed phenotype and preclinical type 2 diabetes mellitus.
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        Value: 10.1038/35050135
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        Text: English
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      – SubjectFull: Protein kinases
        Type: general
      – SubjectFull: Insulin
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      – SubjectFull: Glucose
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      – SubjectFull: Pancreatic beta cells
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              Text: 12/21/2000-12/28/2000
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              Y: 2000
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