Hypoinsulinaemia, glucose intolerance and diminished Beta-cell size in S6K1-deficient mice.
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| Title: | Hypoinsulinaemia, glucose intolerance and diminished Beta-cell size in S6K1-deficient mice. |
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| Authors: | Pende, Mario, Kozma, Sara C., Jaquet, Muriel, Oorschot, Viola, Burcelin, Remy, Le Marchand-Brustel, Yannick, Klumperman, Judith, Thorens, Bernard, Thomas, George |
| Source: | Nature. 12/21/2000-12/28/2000, Vol. 408 Issue 6815, p994. 4p. 4 Color Photographs, 3 Black and White Photographs, 9 Graphs. |
| Subjects: | Protein kinases, Insulin, Glucose, Pancreatic beta cells, Diabetes, Metabolism, Diseases |
| Abstract: | Shows that mice deficient for S6 kinase 1, an effector of the phosphatidylinositide-3-OH kinase signalling pathway, are hypoinsulinaemic and glucose intolerant. Reduction in glucose-induced insulin secretion and in pancreatic insulin production which is due to a reduction in pancreatic endocrine mass cuased by a selective decrease in beta-cell size; Parallel between the observed phenotype and preclinical type 2 diabetes mellitus. |
| Database: | Psychology and Behavioral Sciences Collection |
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