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Evidence for HTR1A and LHPP as interacting genetic risk factors in major depression.

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Title: Evidence for HTR1A and LHPP as interacting genetic risk factors in major depression.
Authors: Neff, C. D., Abkevich, V., Packer, J. C. L., Chen, Y., Potter, J., Riley, R., Davenport, C., DeGrado Warren, J., Jammulapati, S., Bhathena, A., Choi, W. S., Kroeger, P. E., Metzger, R. E., Gutin, A., Skolnick, M. H., Shattuck, D., Katz, D. A.
Source: Molecular Psychiatry. Jun2009, Vol. 14 Issue 6, p621-630. 10p. 2 Diagrams, 2 Charts, 2 Graphs.
Subjects: Mental depression, Human genetics, Nucleotides, Genetic polymorphisms
Geographic Terms: Utah
Abstract: The HTR1A −1019C>G genotype was associated with major depression in the Utah population. Linkage analysis on Utah pedigrees with strong family histories of major depression including only cases with the HTR1A −1019G allele revealed a linkage peak on chromosome 10 (maximum HLOD=4.4). Sequencing of all known genes in the linkage region revealed disease-segregating single-nucleotide polymorphisms (SNPs) in LHPP. LHPP SNPs were also associated with major depression in both Utah and Ashkenazi populations. Consistent with the linkage evidence, LHPP associations depended on HTR1A genotype. Lhpp or a product of a collinear brain-specific transcript, therefore, may interact with Htr1a in the pathogenesis of major depression.Molecular Psychiatry (2009) 14, 621–630; doi:10.1038/mp.2008.8; published online 12 February 2008 [ABSTRACT FROM AUTHOR]
Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Evidence for HTR1A and LHPP as interacting genetic risk factors in major depression.
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  Data: <searchLink fieldCode="AR" term="%22Neff%2C+C%2E+D%2E%22">Neff, C. D.</searchLink><br /><searchLink fieldCode="AR" term="%22Abkevich%2C+V%2E%22">Abkevich, V.</searchLink><br /><searchLink fieldCode="AR" term="%22Packer%2C+J%2E+C%2E+L%2E%22">Packer, J. C. L.</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+Y%2E%22">Chen, Y.</searchLink><br /><searchLink fieldCode="AR" term="%22Potter%2C+J%2E%22">Potter, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Riley%2C+R%2E%22">Riley, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Davenport%2C+C%2E%22">Davenport, C.</searchLink><br /><searchLink fieldCode="AR" term="%22DeGrado+Warren%2C+J%2E%22">DeGrado Warren, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Jammulapati%2C+S%2E%22">Jammulapati, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Bhathena%2C+A%2E%22">Bhathena, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Choi%2C+W%2E+S%2E%22">Choi, W. S.</searchLink><br /><searchLink fieldCode="AR" term="%22Kroeger%2C+P%2E+E%2E%22">Kroeger, P. E.</searchLink><br /><searchLink fieldCode="AR" term="%22Metzger%2C+R%2E+E%2E%22">Metzger, R. E.</searchLink><br /><searchLink fieldCode="AR" term="%22Gutin%2C+A%2E%22">Gutin, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Skolnick%2C+M%2E+H%2E%22">Skolnick, M. H.</searchLink><br /><searchLink fieldCode="AR" term="%22Shattuck%2C+D%2E%22">Shattuck, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Katz%2C+D%2E+A%2E%22">Katz, D. A.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Molecular+Psychiatry%22">Molecular Psychiatry</searchLink>. Jun2009, Vol. 14 Issue 6, p621-630. 10p. 2 Diagrams, 2 Charts, 2 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Human+genetics%22">Human genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Nucleotides%22">Nucleotides</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+polymorphisms%22">Genetic polymorphisms</searchLink>
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  Data: The HTR1A −1019C>G genotype was associated with major depression in the Utah population. Linkage analysis on Utah pedigrees with strong family histories of major depression including only cases with the HTR1A −1019G allele revealed a linkage peak on chromosome 10 (maximum HLOD=4.4). Sequencing of all known genes in the linkage region revealed disease-segregating single-nucleotide polymorphisms (SNPs) in LHPP. LHPP SNPs were also associated with major depression in both Utah and Ashkenazi populations. Consistent with the linkage evidence, LHPP associations depended on HTR1A genotype. Lhpp or a product of a collinear brain-specific transcript, therefore, may interact with Htr1a in the pathogenesis of major depression.Molecular Psychiatry (2009) 14, 621–630; doi:10.1038/mp.2008.8; published online 12 February 2008 [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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