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Beyond the critical period: longitudinal study of 8-year outcome in first-episode non-affective psychosis.

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Title: Beyond the critical period: longitudinal study of 8-year outcome in first-episode non-affective psychosis.
Authors: Crumlish, Niall, Whitty, Peter, Clarke, Mary, Browne, Stephen, Kamali, Moayyad, Gervin, Maurice, McTigue, Orfhlaith, Kinsella, Anthony, Waddington, John L., Larkin, Cornall, O'Callaghan, Eadbhard, Larkin, Conall (AUTHOR)
Source: British Journal of Psychiatry. Jan2009, Vol. 194 Issue 1, p18-24. 7p. 4 Charts, 1 Graph.
Subjects: Psychoses, Social skills, Psychosocial factors, Psychiatry, Patients
Geographic Terms: United Kingdom
Abstract: Background: The critical period hypothesis proposes that deterioration occurs aggressively during the early years of psychosis, with relative stability subsequently. Thus, interventions that shorten the duration of untreated psychosis (DUP) and arrest early deterioration may have long-term benefits.Aims: To test the critical period hypothesis by determining whether outcome in non-affective psychosis stabilises beyond the critical period and whether DUP correlates with 8-year outcome; to determine whether duration of untreated illness (DUI) has any independent effect on outcome.Method: We recruited 118 people consecutively referred with first-episode psychosis to a prospective, naturalistic cohort study.Results: Negative and disorganised symptoms improved between 4 and 8 years. Duration of untreated psychosis predicted remission, positive symptoms and social functioning at 8 years. Continuing functional recovery between 4 and 8 years was predicted by DUI.Conclusions: These results provide qualified support for the critical period hypothesis. The critical period could be extended to include the prodrome as well as early psychosis. [ABSTRACT FROM AUTHOR]
Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Beyond the critical period: longitudinal study of 8-year outcome in first-episode non-affective psychosis.
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  Data: <searchLink fieldCode="AR" term="%22Crumlish%2C+Niall%22">Crumlish, Niall</searchLink><br /><searchLink fieldCode="AR" term="%22Whitty%2C+Peter%22">Whitty, Peter</searchLink><br /><searchLink fieldCode="AR" term="%22Clarke%2C+Mary%22">Clarke, Mary</searchLink><br /><searchLink fieldCode="AR" term="%22Browne%2C+Stephen%22">Browne, Stephen</searchLink><br /><searchLink fieldCode="AR" term="%22Kamali%2C+Moayyad%22">Kamali, Moayyad</searchLink><br /><searchLink fieldCode="AR" term="%22Gervin%2C+Maurice%22">Gervin, Maurice</searchLink><br /><searchLink fieldCode="AR" term="%22McTigue%2C+Orfhlaith%22">McTigue, Orfhlaith</searchLink><br /><searchLink fieldCode="AR" term="%22Kinsella%2C+Anthony%22">Kinsella, Anthony</searchLink><br /><searchLink fieldCode="AR" term="%22Waddington%2C+John+L%2E%22">Waddington, John L.</searchLink><br /><searchLink fieldCode="AR" term="%22Larkin%2C+Cornall%22">Larkin, Cornall</searchLink><br /><searchLink fieldCode="AR" term="%22O'Callaghan%2C+Eadbhard%22">O'Callaghan, Eadbhard</searchLink><br /><searchLink fieldCode="AR" term="%22Larkin%2C+Conall%22">Larkin, Conall</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22British+Journal+of+Psychiatry%22">British Journal of Psychiatry</searchLink>. Jan2009, Vol. 194 Issue 1, p18-24. 7p. 4 Charts, 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Psychoses%22">Psychoses</searchLink><br /><searchLink fieldCode="DE" term="%22Social+skills%22">Social skills</searchLink><br /><searchLink fieldCode="DE" term="%22Psychosocial+factors%22">Psychosocial factors</searchLink><br /><searchLink fieldCode="DE" term="%22Psychiatry%22">Psychiatry</searchLink><br /><searchLink fieldCode="DE" term="%22Patients%22">Patients</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22United+Kingdom%22">United Kingdom</searchLink>
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  Data: <bold>Background: </bold>The critical period hypothesis proposes that deterioration occurs aggressively during the early years of psychosis, with relative stability subsequently. Thus, interventions that shorten the duration of untreated psychosis (DUP) and arrest early deterioration may have long-term benefits.<bold>Aims: </bold>To test the critical period hypothesis by determining whether outcome in non-affective psychosis stabilises beyond the critical period and whether DUP correlates with 8-year outcome; to determine whether duration of untreated illness (DUI) has any independent effect on outcome.<bold>Method: </bold>We recruited 118 people consecutively referred with first-episode psychosis to a prospective, naturalistic cohort study.<bold>Results: </bold>Negative and disorganised symptoms improved between 4 and 8 years. Duration of untreated psychosis predicted remission, positive symptoms and social functioning at 8 years. Continuing functional recovery between 4 and 8 years was predicted by DUI.<bold>Conclusions: </bold>These results provide qualified support for the critical period hypothesis. The critical period could be extended to include the prodrome as well as early psychosis. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of British Journal of Psychiatry is the property of Cambridge University Press and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1192/bjp.bp.107.048942
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        Text: English
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        PageCount: 7
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      – SubjectFull: Psychoses
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      – SubjectFull: Social skills
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      – SubjectFull: United Kingdom
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              Text: Jan2009
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              Y: 2009
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