View in EDS PDF Full Text

Relation between ictal asystole and cardiac sympathetic dysfunction shown by MIBG-SPECT.

Saved in:
Bibliographic Details
Title: Relation between ictal asystole and cardiac sympathetic dysfunction shown by MIBG-SPECT.
Authors: Kerling, F., Dütsch, M., Linke, R., Kuwert, T., Stefan, H., Hilz, M. J.
Source: Acta Neurologica Scandinavica. Aug2009, Vol. 120 Issue 2, p123-129. 7p. 2 Charts, 2 Graphs.
Subjects: Tachyarrhythmias, People with epilepsy, Photon emission, Cardiological manifestations of general diseases, Denervation
Abstract: Objective – Tachyarrhythmias are common during epileptic seizures while bradyarrhythmias or asystoles are less frequent. Ictal asystole might be related to epilepsy-induced cardiac sympathetic denervation. Methods – To evaluate cardiac post-ganglionic denervation in epilepsy patients with ictal asystoles we assessed I123-meta-iodobenzylguanidine (MIBG) as a marker of post-ganglionic cardiac norepinephrine-uptake, using single photon emission computed tomography (MIBG-SPECT). Results – In five of 844 patients with presurgical video-electroencephalography-monitoring, we recorded ictal asystoles during nine of 37 seizures. Asystole patients underwent cardiologic examination (Holter-electrocardiogram, echocardiogram) and cardiac MIBG-SPECT. We compared cardiac MIBG uptake in the asystole patients to the uptake in 18 temporal lobe epilepsy (TLE) patients without bradyarrhythmias and in 14 controls without cardiac or neurological disease. As the cardiological examinations were unremarkable in all subjects, the heart/mediastinum-MIBG-uptake ratios (H/M-ratios) differed significantly between the three groups ( P = 0.004). H/M-ratios were lower in asystole TLE patients (mean ± SD: 1.58 ± 0.3) than in patients without asystole (1.81 ± 0.18; P = 0.037) or controls (1.96 ± 0.16). Conclusions – Pronounced reduction in cardiac MIBG uptake of asystole patients indicates post-ganglionic cardiac catecholamine disturbance. Impaired sympathetic cardiac innervation limits adjustment and heart rate modulation, and may increase the risk of asystole and ultimately sudden unexpected death in epilepsy (SUDEP). [ABSTRACT FROM AUTHOR]
Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 43112769
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Relation between ictal asystole and cardiac sympathetic dysfunction shown by MIBG-SPECT.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Kerling%2C+F%2E%22">Kerling, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Dütsch%2C+M%2E%22">Dütsch, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Linke%2C+R%2E%22">Linke, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Kuwert%2C+T%2E%22">Kuwert, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Stefan%2C+H%2E%22">Stefan, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Hilz%2C+M%2E+J%2E%22">Hilz, M. J.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. Aug2009, Vol. 120 Issue 2, p123-129. 7p. 2 Charts, 2 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Tachyarrhythmias%22">Tachyarrhythmias</searchLink><br /><searchLink fieldCode="DE" term="%22People+with+epilepsy%22">People with epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Photon+emission%22">Photon emission</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiological+manifestations+of+general+diseases%22">Cardiological manifestations of general diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Denervation%22">Denervation</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objective – Tachyarrhythmias are common during epileptic seizures while bradyarrhythmias or asystoles are less frequent. Ictal asystole might be related to epilepsy-induced cardiac sympathetic denervation. Methods – To evaluate cardiac post-ganglionic denervation in epilepsy patients with ictal asystoles we assessed I123-meta-iodobenzylguanidine (MIBG) as a marker of post-ganglionic cardiac norepinephrine-uptake, using single photon emission computed tomography (MIBG-SPECT). Results – In five of 844 patients with presurgical video-electroencephalography-monitoring, we recorded ictal asystoles during nine of 37 seizures. Asystole patients underwent cardiologic examination (Holter-electrocardiogram, echocardiogram) and cardiac MIBG-SPECT. We compared cardiac MIBG uptake in the asystole patients to the uptake in 18 temporal lobe epilepsy (TLE) patients without bradyarrhythmias and in 14 controls without cardiac or neurological disease. As the cardiological examinations were unremarkable in all subjects, the heart/mediastinum-MIBG-uptake ratios (H/M-ratios) differed significantly between the three groups ( P = 0.004). H/M-ratios were lower in asystole TLE patients (mean ± SD: 1.58 ± 0.3) than in patients without asystole (1.81 ± 0.18; P = 0.037) or controls (1.96 ± 0.16). Conclusions – Pronounced reduction in cardiac MIBG uptake of asystole patients indicates post-ganglionic cardiac catecholamine disturbance. Impaired sympathetic cardiac innervation limits adjustment and heart rate modulation, and may increase the risk of asystole and ultimately sudden unexpected death in epilepsy (SUDEP). [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=43112769
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/j.1600-0404.2008.01135.x
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 123
    Subjects:
      – SubjectFull: Tachyarrhythmias
        Type: general
      – SubjectFull: People with epilepsy
        Type: general
      – SubjectFull: Photon emission
        Type: general
      – SubjectFull: Cardiological manifestations of general diseases
        Type: general
      – SubjectFull: Denervation
        Type: general
    Titles:
      – TitleFull: Relation between ictal asystole and cardiac sympathetic dysfunction shown by MIBG-SPECT.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Kerling, F.
      – PersonEntity:
          Name:
            NameFull: Dütsch, M.
      – PersonEntity:
          Name:
            NameFull: Linke, R.
      – PersonEntity:
          Name:
            NameFull: Kuwert, T.
      – PersonEntity:
          Name:
            NameFull: Stefan, H.
      – PersonEntity:
          Name:
            NameFull: Hilz, M. J.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: Aug2009
              Type: published
              Y: 2009
          Identifiers:
            – Type: issn-print
              Value: 00016314
          Numbering:
            – Type: volume
              Value: 120
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Acta Neurologica Scandinavica
              Type: main
ResultId 1