Basilar artery atherosclerotic disease is related to subacute lesion volume increase in pontine base infarction.

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Title:	Basilar artery atherosclerotic disease is related to subacute lesion volume increase in pontine base infarction.
Authors:	Kim, J. S., Cho, K.-H., Kang, D.-W., Kwon, S. U., Suh, D. C.
Source:	Acta Neurologica Scandinavica. Aug2009, Vol. 120 Issue 2, p88-93. 6p. 1 Black and White Photograph, 1 Chart.
Subjects:	Atherosclerosis, Vertebrobasilar insufficiency, Magnetic resonance imaging, Neurological errors, Infarction
Abstract:	Background – Although basilar artery atherosclerotic disease (BAD) is frequent in patients with pontine base infarction, it remains unknown whether BAD is related to the lesion size or clinical outcome. Methods – We studied 56 patients with unilateral pontine base infarction who underwent (i) diffusion-weighted MRI within 48 h after stroke onset and (ii) follow-up MRI and MR angiography in the subacute stage. Neurologic progression was defined as increased National Institutes of Health Stroke Scale score by ≥ 2 during admission. Clinical outcome was dichotomized as good and poor (≥ 3) according to the modified Rankin Scale at 1 month after stroke onset. Results – Twenty-two patients (39%) had BAD and 15 patients (27%) had neurologic progression. Follow-up MRI performed at median 3.5 ± 1.1 days after the initial MRI showed the lesion volume significantly increased ( P < 0.001). The BAD was not significantly related to demographic characteristics, risk factors, initial and follow-up lesion volume, neurologic progression and clinical outcome, but was closely related to the subacute increase in lesion volume ( P = 0.004 for 20% increase, P = 0.029 for 50% increase). Conclusions – BAD is related to subacute increase in lesion volume, but not to ultimate poor clinical outcome in patients with pontine base infarction. [ABSTRACT FROM AUTHOR]
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Database:	Psychology and Behavioral Sciences Collection

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Abstract:	Background – Although basilar artery atherosclerotic disease (BAD) is frequent in patients with pontine base infarction, it remains unknown whether BAD is related to the lesion size or clinical outcome. Methods – We studied 56 patients with unilateral pontine base infarction who underwent (i) diffusion-weighted MRI within 48 h after stroke onset and (ii) follow-up MRI and MR angiography in the subacute stage. Neurologic progression was defined as increased National Institutes of Health Stroke Scale score by ≥ 2 during admission. Clinical outcome was dichotomized as good and poor (≥ 3) according to the modified Rankin Scale at 1 month after stroke onset. Results – Twenty-two patients (39%) had BAD and 15 patients (27%) had neurologic progression. Follow-up MRI performed at median 3.5 ± 1.1 days after the initial MRI showed the lesion volume significantly increased ( P < 0.001). The BAD was not significantly related to demographic characteristics, risk factors, initial and follow-up lesion volume, neurologic progression and clinical outcome, but was closely related to the subacute increase in lesion volume ( P = 0.004 for 20% increase, P = 0.029 for 50% increase). Conclusions – BAD is related to subacute increase in lesion volume, but not to ultimate poor clinical outcome in patients with pontine base infarction. [ABSTRACT FROM AUTHOR]
ISSN:	00016314
DOI:	10.1111/j.1600-0404.2008.01124.x