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Experimental Autoimmune Labyrinthitis Induced by Cell-mediated Immune Reaction.

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Title: Experimental Autoimmune Labyrinthitis Induced by Cell-mediated Immune Reaction.
Authors: Tomiyama, Shunichi, Jinnouchi, Ken, Ikezono, Tetsuo, Pawankar, Ruby, Yagi, Toshiaki
Source: Acta Oto-Laryngologica. 12/20/99, Vol. 119 Issue 6, p665-670. 6p. 7 Black and White Photographs, 4 Charts.
Subjects: Inner ear, Immunology
Abstract: This study was designed to establish an experimental cell-mediated autoimmune labyrinthitis model in C57BL/6 mice, which could exhibit high reproducibility and be adopted for precise immunological analysis. Inner ear antigen (IEA) was prepared from bovine membranous labyrinth. Following pretreatment with cyclophosphamide (CP) and primary sensitization with IEA/FCA, many inflammatory cells infiltrated transiently into the perilymphatic and endolymphatic regions of the cochlea, vestibule and the endolymphatic sac, but not into the kidney, lung, brain or liver. This reaction occurred from day 7 and peaked on day 12 in all animals, and then rapidly reduced. This reaction occurred in all experimental mice during day 10 to day 12. The control mice showed no cellular reaction in the inner ear. These results suggest that the inner ear may possess cross-species organ-specific antigen and that a cell-mediated immune reaction may play an important role in the induction of autoimmune labyrinthitis. [ABSTRACT FROM AUTHOR]
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Experimental Autoimmune Labyrinthitis Induced by Cell-mediated Immune Reaction.
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  Data: <searchLink fieldCode="AR" term="%22Tomiyama%2C+Shunichi%22">Tomiyama, Shunichi</searchLink><br /><searchLink fieldCode="AR" term="%22Jinnouchi%2C+Ken%22">Jinnouchi, Ken</searchLink><br /><searchLink fieldCode="AR" term="%22Ikezono%2C+Tetsuo%22">Ikezono, Tetsuo</searchLink><br /><searchLink fieldCode="AR" term="%22Pawankar%2C+Ruby%22">Pawankar, Ruby</searchLink><br /><searchLink fieldCode="AR" term="%22Yagi%2C+Toshiaki%22">Yagi, Toshiaki</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica%22">Acta Oto-Laryngologica</searchLink>. 12/20/99, Vol. 119 Issue 6, p665-670. 6p. 7 Black and White Photographs, 4 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Inner+ear%22">Inner ear</searchLink><br /><searchLink fieldCode="DE" term="%22Immunology%22">Immunology</searchLink>
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  Label: Abstract
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  Data: This study was designed to establish an experimental cell-mediated autoimmune labyrinthitis model in C57BL/6 mice, which could exhibit high reproducibility and be adopted for precise immunological analysis. Inner ear antigen (IEA) was prepared from bovine membranous labyrinth. Following pretreatment with cyclophosphamide (CP) and primary sensitization with IEA/FCA, many inflammatory cells infiltrated transiently into the perilymphatic and endolymphatic regions of the cochlea, vestibule and the endolymphatic sac, but not into the kidney, lung, brain or liver. This reaction occurred from day 7 and peaked on day 12 in all animals, and then rapidly reduced. This reaction occurred in all experimental mice during day 10 to day 12. The control mice showed no cellular reaction in the inner ear. These results suggest that the inner ear may possess cross-species organ-specific antigen and that a cell-mediated immune reaction may play an important role in the induction of autoimmune labyrinthitis. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1080/00016489950180603
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        Text: English
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        Type: general
      – SubjectFull: Immunology
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      – TitleFull: Experimental Autoimmune Labyrinthitis Induced by Cell-mediated Immune Reaction.
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              Text: 12/20/99
              Type: published
              Y: 1999
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              Value: 119
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