Induction of the mammalian node requires Arkadia function in the extraembryonic lineages.

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Bibliographic Details
Title:	Induction of the mammalian node requires Arkadia function in the extraembryonic lineages.
Authors:	Episkopou, Vasso, Arkell, Ruth, Timmons, Paula M., Walsh, James J., Andrew, Rebecca L., Swan, Daniel
Source:	Nature. 4/12/2001, Vol. 410 Issue 6830, p825. 6p. 27 Color Photographs, 1 Black and White Photograph, 2 Diagrams.
Subjects:	Embryonic stem cells, Genetic mutation, Mutagenesis, Transforming growth factors
Abstract:	Presents a study of arkadia, a recessive lethal mutation generated using gene-trap mutagenesis in embryonic stem cells. Analysis with chimaeras, which shows that Arkadia functions within extraembryonic tissues; Results which show that Arkadia interacts genetically with the transforming growth factor beta-like factor Nodal; Implication that Nodal mediates the function of Arkadia in node induction.
Database:	Psychology and Behavioral Sciences Collection

Description
Abstract:	Presents a study of arkadia, a recessive lethal mutation generated using gene-trap mutagenesis in embryonic stem cells. Analysis with chimaeras, which shows that Arkadia functions within extraembryonic tissues; Results which show that Arkadia interacts genetically with the transforming growth factor beta-like factor Nodal; Implication that Nodal mediates the function of Arkadia in node induction.
ISSN:	00280836
DOI:	10.1038/35071095