Induction of the mammalian node requires Arkadia function in the extraembryonic lineages.
Saved in:
| Title: | Induction of the mammalian node requires Arkadia function in the extraembryonic lineages. |
|---|---|
| Authors: | Episkopou, Vasso, Arkell, Ruth, Timmons, Paula M., Walsh, James J., Andrew, Rebecca L., Swan, Daniel |
| Source: | Nature. 4/12/2001, Vol. 410 Issue 6830, p825. 6p. 27 Color Photographs, 1 Black and White Photograph, 2 Diagrams. |
| Subjects: | Embryonic stem cells, Genetic mutation, Mutagenesis, Transforming growth factors |
| Abstract: | Presents a study of arkadia, a recessive lethal mutation generated using gene-trap mutagenesis in embryonic stem cells. Analysis with chimaeras, which shows that Arkadia functions within extraembryonic tissues; Results which show that Arkadia interacts genetically with the transforming growth factor beta-like factor Nodal; Implication that Nodal mediates the function of Arkadia in node induction. |
| Database: | Psychology and Behavioral Sciences Collection |
Be the first to leave a comment!
