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Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans.

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Title: Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans.
Authors: Garten, Rebecca J., Davis, C. Todd, Russell, Colin A., Bo Shu, Lindstrom, Stephen, Balish, Amanda, Sessions, Wendy M., Xiyan Xu, Skepner, Eugene, Deyde, Varough, Okomo-Adhiambo, Margaret, Gubareva, Larisa, Barnes, John, Smith, Catherine B., Emery, Shannon L., Hillman, Michael J., Rivailler, Pierre, Smagala, James, de Graaf, Miranda, Burke, David F.
Source: Science (pre-March 2025). 7/10/2009, Vol. 325 Issue 5937, p197-201. 5p.
Subjects: Swine influenza, Influenza viruses, Epitopes, Immunogenetics, Viral genetics, Biological adaptation, Infectious disease transmission
Abstract: Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The Jack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period. Its low genetic diversity suggests that the introduction into humans was a single event or multiple events of similar viruses. Molecular markers predictive of adaptation to humans are not currently present in 2009 A(H1N1) viruses, suggesting that previously unrecognized molecular determinants could be responsible for the transmission among humans. Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1). [ABSTRACT FROM AUTHOR]
Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 7/10/2009, Vol. 325 Issue 5937, p197-201. 5p.
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  Data: <searchLink fieldCode="DE" term="%22Swine+influenza%22">Swine influenza</searchLink><br /><searchLink fieldCode="DE" term="%22Influenza+viruses%22">Influenza viruses</searchLink><br /><searchLink fieldCode="DE" term="%22Epitopes%22">Epitopes</searchLink><br /><searchLink fieldCode="DE" term="%22Immunogenetics%22">Immunogenetics</searchLink><br /><searchLink fieldCode="DE" term="%22Viral+genetics%22">Viral genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Biological+adaptation%22">Biological adaptation</searchLink><br /><searchLink fieldCode="DE" term="%22Infectious+disease+transmission%22">Infectious disease transmission</searchLink>
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  Data: Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The Jack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period. Its low genetic diversity suggests that the introduction into humans was a single event or multiple events of similar viruses. Molecular markers predictive of adaptation to humans are not currently present in 2009 A(H1N1) viruses, suggesting that previously unrecognized molecular determinants could be responsible for the transmission among humans. Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1). [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Science (pre-March 2025) is the property of American Association for the Advancement of Science and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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