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No Association Between Cholinergic Muscarinic Receptor 2 ( CHRM2) Genetic Variation and Cognitive Abilities in Three Independent Samples.

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Title: No Association Between Cholinergic Muscarinic Receptor 2 ( CHRM2) Genetic Variation and Cognitive Abilities in Three Independent Samples.
Authors: Lind, Penelope A., Luciano, Michelle, Horan, Michael A., Marioni, Riccardo E., Wright, Margaret J., Bates, Timothy C., Rabbitt, Patrick, Harris, Sarah E., Davidson, Yvonne, Deary, Ian J., Gibbons, Linda, Pickles, Andrew, Ollier, William, Pendleton, Neil, Price, Jackie F., Payton, Antony, Martin, Nicholas G.
Source: Behavior Genetics. Sep2009, Vol. 39 Issue 5, p513-523. 11p. 1 Diagram, 3 Charts.
Subjects: Cholinergic receptors, Cognitive ability, Human genetic variation, Genes, Older people
Abstract: Cognitive ability has a substantial genetic component and more than 15 candidate genes have been identified over the past 8 years. One gene that has been associated with general cognitive ability is the cholinergic muscarinic 2 receptor ( CHRM2). In an attempt to replicate this finding we typed marker rs8191992 (the originally reported CHRM2 SNP) in two population based cohorts—one Scottish aged over 50 years ( N = 2,091) and the other English comprising non-demented elderly participants ( N = 758)—and a family-based Australian adolescent sample ( N = 1,537). An additional 29 SNPs in CHRM2 were typed in the Australian sample and a further seven in the English cohort. No significant association was found between CHRM2 and diverse measures of cognitive ability in any of the samples. In conclusion, this study does not support a role for CHRM2 in cognitive ability. [ABSTRACT FROM AUTHOR]
Copyright of Behavior Genetics is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: No Association Between Cholinergic Muscarinic Receptor 2 ( CHRM2) Genetic Variation and Cognitive Abilities in Three Independent Samples.
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  Data: Cognitive ability has a substantial genetic component and more than 15 candidate genes have been identified over the past 8 years. One gene that has been associated with general cognitive ability is the cholinergic muscarinic 2 receptor ( CHRM2). In an attempt to replicate this finding we typed marker rs8191992 (the originally reported CHRM2 SNP) in two population based cohorts—one Scottish aged over 50 years ( N = 2,091) and the other English comprising non-demented elderly participants ( N = 758)—and a family-based Australian adolescent sample ( N = 1,537). An additional 29 SNPs in CHRM2 were typed in the Australian sample and a further seven in the English cohort. No significant association was found between CHRM2 and diverse measures of cognitive ability in any of the samples. In conclusion, this study does not support a role for CHRM2 in cognitive ability. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Behavior Genetics is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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