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Effect of ACE inhibitors on angiographic restenosis after coronary stenting (PARIS): a randomised, double-blind, placebo-controlled trial.

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Title: Effect of ACE inhibitors on angiographic restenosis after coronary stenting (PARIS): a randomised, double-blind, placebo-controlled trial.
Authors: Meurice, Thibaud, Bauters, Christophe, Hermant, Xavier, Codron, Valerie, VanBelle, Eric, Mc Fadden, Eugegravene P, Lablanche, Jean-Marc, Bertrand, Michel E, Amouyel, Philippe, Meurice, T (AUTHOR), Bauters, C (AUTHOR), Hermant, X (AUTHOR), Codron, V (AUTHOR), VanBelle, E (AUTHOR), Mc Fadden, E P (AUTHOR), Lablanche, J (AUTHOR), Bertrand, M E (AUTHOR), Amouyel, P (AUTHOR)
Source: Lancet. 4/28/2001, Vol. 357 Issue 9265, p1321-1324. 4p. 1 Diagram, 2 Charts.
Subjects: Coronary restenosis prevention, Genetic polymorphisms, ACE inhibitors, Surgical stents
Abstract: Background: The DD genotype for the angiotensin-I converting enzyme (ACE I) deletion allele (D) polymorphism is a possible genetic risk factor for restenosis after coronary stent implantation. We aimed to establish whether or not blockade of ACE with high doses of ACE inhibitors could reduce this risk of angiographic restenosis.Methods: We characterised the ACE I/D polymorphism in 345 consecutive patients who were undergoing coronary stenting. 115 had the DD genotype. We assigned 91 of these 115 patients to quinapril 40 mg daily (n=46) or placebo (n=45). Treatment was started within 48 h after stent implantation and continued for 6 months. 79 patients complied with the protocol and underwent follow-up angiography after 6 months.Findings: Our primary endpoint of late loss in minimum lumen diameter (a quantitative index of restenosis) was significantly higher in the quinapril group than in the controls (mean 1.11 mm [SD 0.70] vs 0.76 mm [0.60]; p=0.018). Secondary endpoints also showed consistent trends towards increased angiographic restenosis in the treatment group.Interpretation: Contrary to our expectations, ACE inhibitor treatment did not reduce restenosis after coronary stent implantation in patients with DD genotype, but was associated with an exaggerated restenotic process when compared with administration of placebo. [ABSTRACT FROM AUTHOR]
Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Effect of ACE inhibitors on angiographic restenosis after coronary stenting (PARIS): a randomised, double-blind, placebo-controlled trial.
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  Data: <searchLink fieldCode="AR" term="%22Meurice%2C+Thibaud%22">Meurice, Thibaud</searchLink><br /><searchLink fieldCode="AR" term="%22Bauters%2C+Christophe%22">Bauters, Christophe</searchLink><br /><searchLink fieldCode="AR" term="%22Hermant%2C+Xavier%22">Hermant, Xavier</searchLink><br /><searchLink fieldCode="AR" term="%22Codron%2C+Valerie%22">Codron, Valerie</searchLink><br /><searchLink fieldCode="AR" term="%22VanBelle%2C+Eric%22">VanBelle, Eric</searchLink><br /><searchLink fieldCode="AR" term="%22Mc+Fadden%2C+Eugegravene+P%22">Mc Fadden, Eugegravene P</searchLink><br /><searchLink fieldCode="AR" term="%22Lablanche%2C+Jean-Marc%22">Lablanche, Jean-Marc</searchLink><br /><searchLink fieldCode="AR" term="%22Bertrand%2C+Michel+E%22">Bertrand, Michel E</searchLink><br /><searchLink fieldCode="AR" term="%22Amouyel%2C+Philippe%22">Amouyel, Philippe</searchLink><br /><searchLink fieldCode="AR" term="%22Meurice%2C+T%22">Meurice, T</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bauters%2C+C%22">Bauters, C</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hermant%2C+X%22">Hermant, X</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Codron%2C+V%22">Codron, V</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22VanBelle%2C+E%22">VanBelle, E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mc+Fadden%2C+E+P%22">Mc Fadden, E P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lablanche%2C+J%22">Lablanche, J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bertrand%2C+M+E%22">Bertrand, M E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Amouyel%2C+P%22">Amouyel, P</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Lancet%22">Lancet</searchLink>. 4/28/2001, Vol. 357 Issue 9265, p1321-1324. 4p. 1 Diagram, 2 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Coronary+restenosis+prevention%22">Coronary restenosis prevention</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+polymorphisms%22">Genetic polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22ACE+inhibitors%22">ACE inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Surgical+stents%22">Surgical stents</searchLink>
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  Label: Abstract
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  Data: <bold>Background: </bold>The DD genotype for the angiotensin-I converting enzyme (ACE I) deletion allele (D) polymorphism is a possible genetic risk factor for restenosis after coronary stent implantation. We aimed to establish whether or not blockade of ACE with high doses of ACE inhibitors could reduce this risk of angiographic restenosis.<bold>Methods: </bold>We characterised the ACE I/D polymorphism in 345 consecutive patients who were undergoing coronary stenting. 115 had the DD genotype. We assigned 91 of these 115 patients to quinapril 40 mg daily (n=46) or placebo (n=45). Treatment was started within 48 h after stent implantation and continued for 6 months. 79 patients complied with the protocol and underwent follow-up angiography after 6 months.<bold>Findings: </bold>Our primary endpoint of late loss in minimum lumen diameter (a quantitative index of restenosis) was significantly higher in the quinapril group than in the controls (mean 1.11 mm [SD 0.70] vs 0.76 mm [0.60]; p=0.018). Secondary endpoints also showed consistent trends towards increased angiographic restenosis in the treatment group.<bold>Interpretation: </bold>Contrary to our expectations, ACE inhibitor treatment did not reduce restenosis after coronary stent implantation in patients with DD genotype, but was associated with an exaggerated restenotic process when compared with administration of placebo. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Lancet is the property of Lancet and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/S0140-6736(00)04518-9
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