Deep Brain Stimulation of the Subthalamic Nucleus Facilitates Coordination of Hand Preshaping in Parkinson's Disease.
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| Title: | Deep Brain Stimulation of the Subthalamic Nucleus Facilitates Coordination of Hand Preshaping in Parkinson's Disease. |
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| Authors: | Schettino, L. F. (AUTHOR), Van Erp, E. (AUTHOR), Hening, W. (AUTHOR), Lessig, S. (AUTHOR), Song, D. (AUTHOR), Barba, D. (AUTHOR), Poizner, H. (AUTHOR) |
| Source: | International Journal of Neuroscience. Oct2009, Vol. 119 Issue 10, p1905-1924. 20p. 2 Charts, 5 Graphs. |
| Subjects: | Brain stimulation, Parkinson's disease, Movement sequences, Eye-hand coordination, Motor ability |
| Abstract: | Several studies have found that Parkinson's disease (PD) disrupts the organization of complex motor sequences regardless of the influence of parkinsonian medications. A clear candidate for the neural bases of such deficits, which we term “coordinative,” is the failure to integrate propioceptive and visual information by cortico-striatal circuits in a timed fashion. Recent reports, however, have indicated that deep-brain stimulation of the subthalamic nucleus (STN DBS) may result in an improvement in coordinative deficits beyond the amelioration of “intensive deficits” such as bradykinesia and scaling errors. The present study examined the spatio-temporal organization underlying the shaping of the hand during reaching to grasp objects differing in shape. Six PD patients ON and OFF their STN DBS when OFF their concomitant medications and six age-matched controls participated in this study. STN DBS improved the coordination involved in preshaping the hand while grasping. We discuss these results in light of our earlier work with PD patients on and off dopamine replacement therapy. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Several studies have found that Parkinson's disease (PD) disrupts the organization of complex motor sequences regardless of the influence of parkinsonian medications. A clear candidate for the neural bases of such deficits, which we term “coordinative,” is the failure to integrate propioceptive and visual information by cortico-striatal circuits in a timed fashion. Recent reports, however, have indicated that deep-brain stimulation of the subthalamic nucleus (STN DBS) may result in an improvement in coordinative deficits beyond the amelioration of “intensive deficits” such as bradykinesia and scaling errors. The present study examined the spatio-temporal organization underlying the shaping of the hand during reaching to grasp objects differing in shape. Six PD patients ON and OFF their STN DBS when OFF their concomitant medications and six age-matched controls participated in this study. STN DBS improved the coordination involved in preshaping the hand while grasping. We discuss these results in light of our earlier work with PD patients on and off dopamine replacement therapy. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00207454 |
| DOI: | 10.1080/00207450903245296 |
