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Deep Brain Stimulation of the Subthalamic Nucleus Facilitates Coordination of Hand Preshaping in Parkinson's Disease.

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Title: Deep Brain Stimulation of the Subthalamic Nucleus Facilitates Coordination of Hand Preshaping in Parkinson's Disease.
Authors: Schettino, L. F. (AUTHOR), Van Erp, E. (AUTHOR), Hening, W. (AUTHOR), Lessig, S. (AUTHOR), Song, D. (AUTHOR), Barba, D. (AUTHOR), Poizner, H. (AUTHOR)
Source: International Journal of Neuroscience. Oct2009, Vol. 119 Issue 10, p1905-1924. 20p. 2 Charts, 5 Graphs.
Subjects: Brain stimulation, Parkinson's disease, Movement sequences, Eye-hand coordination, Motor ability
Abstract: Several studies have found that Parkinson's disease (PD) disrupts the organization of complex motor sequences regardless of the influence of parkinsonian medications. A clear candidate for the neural bases of such deficits, which we term “coordinative,” is the failure to integrate propioceptive and visual information by cortico-striatal circuits in a timed fashion. Recent reports, however, have indicated that deep-brain stimulation of the subthalamic nucleus (STN DBS) may result in an improvement in coordinative deficits beyond the amelioration of “intensive deficits” such as bradykinesia and scaling errors. The present study examined the spatio-temporal organization underlying the shaping of the hand during reaching to grasp objects differing in shape. Six PD patients ON and OFF their STN DBS when OFF their concomitant medications and six age-matched controls participated in this study. STN DBS improved the coordination involved in preshaping the hand while grasping. We discuss these results in light of our earlier work with PD patients on and off dopamine replacement therapy. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Deep Brain Stimulation of the Subthalamic Nucleus Facilitates Coordination of Hand Preshaping in Parkinson's Disease.
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  Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Oct2009, Vol. 119 Issue 10, p1905-1924. 20p. 2 Charts, 5 Graphs.
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  Data: Several studies have found that Parkinson's disease (PD) disrupts the organization of complex motor sequences regardless of the influence of parkinsonian medications. A clear candidate for the neural bases of such deficits, which we term “coordinative,” is the failure to integrate propioceptive and visual information by cortico-striatal circuits in a timed fashion. Recent reports, however, have indicated that deep-brain stimulation of the subthalamic nucleus (STN DBS) may result in an improvement in coordinative deficits beyond the amelioration of “intensive deficits” such as bradykinesia and scaling errors. The present study examined the spatio-temporal organization underlying the shaping of the hand during reaching to grasp objects differing in shape. Six PD patients ON and OFF their STN DBS when OFF their concomitant medications and six age-matched controls participated in this study. STN DBS improved the coordination involved in preshaping the hand while grasping. We discuss these results in light of our earlier work with PD patients on and off dopamine replacement therapy. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=44192624
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        Value: 10.1080/00207450903245296
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              Text: Oct2009
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