Brain surface contraction mapped in first-episode schizophrenia: a longitudinal magnetic resonance imaging study.
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| Title: | Brain surface contraction mapped in first-episode schizophrenia: a longitudinal magnetic resonance imaging study. |
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| Authors: | Sun, D., Stuart, G. W., Jenkinson, M., Wood, S. J., McGorry, P. D., Velakoulis, D., van Erp, T. G. M., Thompson, P. M., Toga, A. W., Smith, D. J., Cannon, T. D., Pantelis, C. |
| Source: | Molecular Psychiatry. Oct2009, Vol. 14 Issue 10, p976-986. 11p. 3 Color Photographs, 1 Chart, 2 Graphs. |
| Subjects: | Psychoses, Diagnostic imaging, Magnetic resonance imaging, Cerebral cortex, Mental illness |
| Abstract: | Schizophrenia is associated with structural brain abnormalities, but the timing of onset and course of these changes remains unclear. Longitudinal magnetic resonance imaging (MRI) studies have demonstrated progressive brain volume decreases in patients around and after the onset of illness, although considerable discrepancies exist regarding which brain regions are affected. The anatomical pattern of these progressive changes in schizophrenia is largely unknown. In this study, MRI scans were acquired repeatedly from 16 schizophrenia patients approximately 2 years apart following their first episode of illness, and also from 14 age-matched healthy subjects. Cortical Pattern Matching, in combination with Structural Image Evaluation, using Normalisation, of Atrophy, was applied to compare the rates of cortical surface contraction between patients and controls. Surface contraction in the dorsal surfaces of the frontal lobe was significantly greater in patients with first-episode schizophrenia (FESZ) compared with healthy controls. Overall, brain surface contraction in patients and healthy controls showed similar anatomical patterns, with that of the former group exaggerated in magnitude across the entire brain surface. That the pattern of structural change in the early course of schizophrenia corresponds so closely to that associated with normal development is consistent with the hypothesis that a schizophrenia-related factor interacts with normal adolescent brain developmental processes in the pathophysiology of schizophrenia. The exaggerated progressive changes seen in patients with schizophrenia may reflect an increased rate of synaptic pruning, resulting in excessive loss of neuronal connectivity, as predicted by the late neurodevelopmental hypothesis of the illness. [ABSTRACT FROM AUTHOR] |
| Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 44345141 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/mp.2008.34 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 976 Subjects: – SubjectFull: Psychoses Type: general – SubjectFull: Diagnostic imaging Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Cerebral cortex Type: general – SubjectFull: Mental illness Type: general Titles: – TitleFull: Brain surface contraction mapped in first-episode schizophrenia: a longitudinal magnetic resonance imaging study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sun, D. – PersonEntity: Name: NameFull: Stuart, G. W. – PersonEntity: Name: NameFull: Jenkinson, M. – PersonEntity: Name: NameFull: Wood, S. J. – PersonEntity: Name: NameFull: McGorry, P. D. – PersonEntity: Name: NameFull: Velakoulis, D. – PersonEntity: Name: NameFull: van Erp, T. G. M. – PersonEntity: Name: NameFull: Thompson, P. M. – PersonEntity: Name: NameFull: Toga, A. W. – PersonEntity: Name: NameFull: Smith, D. J. – PersonEntity: Name: NameFull: Cannon, T. D. – PersonEntity: Name: NameFull: Pantelis, C. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2009 Type: published Y: 2009 Identifiers: – Type: issn-print Value: 13594184 Numbering: – Type: volume Value: 14 – Type: issue Value: 10 Titles: – TitleFull: Molecular Psychiatry Type: main |
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