View in EDS PDF Full Text

Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia.

Saved in:
Bibliographic Details
Title: Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia.
Authors: Scarr, E., Cowie, T. F., Kanellakis, S., Sundram, S., Pantelis, C., Dean, B.
Source: Molecular Psychiatry. Nov2009, Vol. 14 Issue 11, p1017-1023. 7p. 1 Chart, 2 Graphs.
Subjects: Schizophrenia, Prefrontal cortex, Brain imaging, Neuropsychopharmacology, Acetylcholine, Pirenzepine
Abstract: Schizophrenia is widely acknowledged as being a syndrome, consisting of an undefined number of diseases probably with differing pathologies. Although studying a syndrome makes the identification of an underlying pathology more difficult; neuroimaging, neuropsychopharmacological and post-mortem brain studies all implicate muscarinic acetylcholine receptors (CHRM) in the pathology of the disorder. We have established that the CHRM1 is selectively decreased in the dorsolateral prefrontal cortex of subjects with schizophrenia. To expand this finding, we wanted to ascertain whether decreased cortical CHRMs might (1) define a subgroup of schizophrenia and/or (2) be related to CHRM1 genotype. We assessed cortical [3H]pirenzepine binding and sequenced the CHRM1 in 80 subjects with schizophrenia and 74 age sex-matched control subjects. Kernel density estimation showed that [3H]pirenzepine binding in BA9 divided the schizophrenia, but not control, cohort into two distinct populations. One of the schizophrenia cohorts, comprising 26% of all subjects with the disorder, had a 74% reduction in mean cortical [3H]pirenzepine binding compared to controls. We suggest that these individuals make up ‘muscarinic receptor-deficit schizophrenia’ (MRDS). The MRDS could not be separated from other subjects with schizophrenia by CHRM1 sequence, gender, age, suicide, duration of illness or any particular drug treatment. Being able to define a subgroup within schizophrenia using a central biological parameter is a pivotal step towards understanding the biochemistry underlying at least one form of the disorder and may represent a biomarker that can be used in neuroimaging. [ABSTRACT FROM AUTHOR]
Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 44733381
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Scarr%2C+E%2E%22">Scarr, E.</searchLink><br /><searchLink fieldCode="AR" term="%22Cowie%2C+T%2E+F%2E%22">Cowie, T. F.</searchLink><br /><searchLink fieldCode="AR" term="%22Kanellakis%2C+S%2E%22">Kanellakis, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Sundram%2C+S%2E%22">Sundram, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Pantelis%2C+C%2E%22">Pantelis, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Dean%2C+B%2E%22">Dean, B.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Molecular+Psychiatry%22">Molecular Psychiatry</searchLink>. Nov2009, Vol. 14 Issue 11, p1017-1023. 7p. 1 Chart, 2 Graphs.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Prefrontal+cortex%22">Prefrontal cortex</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+imaging%22">Brain imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychopharmacology%22">Neuropsychopharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Acetylcholine%22">Acetylcholine</searchLink><br /><searchLink fieldCode="DE" term="%22Pirenzepine%22">Pirenzepine</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Schizophrenia is widely acknowledged as being a syndrome, consisting of an undefined number of diseases probably with differing pathologies. Although studying a syndrome makes the identification of an underlying pathology more difficult; neuroimaging, neuropsychopharmacological and post-mortem brain studies all implicate muscarinic acetylcholine receptors (CHRM) in the pathology of the disorder. We have established that the CHRM1 is selectively decreased in the dorsolateral prefrontal cortex of subjects with schizophrenia. To expand this finding, we wanted to ascertain whether decreased cortical CHRMs might (1) define a subgroup of schizophrenia and/or (2) be related to CHRM1 genotype. We assessed cortical [3H]pirenzepine binding and sequenced the CHRM1 in 80 subjects with schizophrenia and 74 age sex-matched control subjects. Kernel density estimation showed that [3H]pirenzepine binding in BA9 divided the schizophrenia, but not control, cohort into two distinct populations. One of the schizophrenia cohorts, comprising 26% of all subjects with the disorder, had a 74% reduction in mean cortical [3H]pirenzepine binding compared to controls. We suggest that these individuals make up ‘muscarinic receptor-deficit schizophrenia’ (MRDS). The MRDS could not be separated from other subjects with schizophrenia by CHRM1 sequence, gender, age, suicide, duration of illness or any particular drug treatment. Being able to define a subgroup within schizophrenia using a central biological parameter is a pivotal step towards understanding the biochemistry underlying at least one form of the disorder and may represent a biomarker that can be used in neuroimaging. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=44733381
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/mp.2008.28
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 1017
    Subjects:
      – SubjectFull: Schizophrenia
        Type: general
      – SubjectFull: Prefrontal cortex
        Type: general
      – SubjectFull: Brain imaging
        Type: general
      – SubjectFull: Neuropsychopharmacology
        Type: general
      – SubjectFull: Acetylcholine
        Type: general
      – SubjectFull: Pirenzepine
        Type: general
    Titles:
      – TitleFull: Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Scarr, E.
      – PersonEntity:
          Name:
            NameFull: Cowie, T. F.
      – PersonEntity:
          Name:
            NameFull: Kanellakis, S.
      – PersonEntity:
          Name:
            NameFull: Sundram, S.
      – PersonEntity:
          Name:
            NameFull: Pantelis, C.
      – PersonEntity:
          Name:
            NameFull: Dean, B.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 11
              Text: Nov2009
              Type: published
              Y: 2009
          Identifiers:
            – Type: issn-print
              Value: 13594184
          Numbering:
            – Type: volume
              Value: 14
            – Type: issue
              Value: 11
          Titles:
            – TitleFull: Molecular Psychiatry
              Type: main
ResultId 1