The Importance of Toxoplasma Gondii Infection in Diseases Presenting with Headaches. Headaches and Aseptic Meningitis May be Manifestations of the Jarisch-Herxheimer Reaction.
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| Title: | The Importance of Toxoplasma Gondii Infection in Diseases Presenting with Headaches. Headaches and Aseptic Meningitis May be Manifestations of the Jarisch-Herxheimer Reaction. |
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| Authors: | PRANDOTA, JOSEPH (AUTHOR) |
| Source: | International Journal of Neuroscience. Dec2009, Vol. 119 Issue 12, p2144-2182. 39p. 6 Charts. |
| Subjects: | Brain tumors, Celiac disease, Cerebral toxoplasmosis, Epilepsy, Schoenlein-Henoch purpura, Migraine, Meningitis |
| Abstract: | Worldwide, approximately 2 billion people are chronically infected with T. gondii with largely unknown consequences. This review presents clinical symptoms, differential diagnosis, triggering factors, treatment, and pathomechanisms responsible for idiopathic intracranial hypertension, pseudotumor cerebri, and aseptic meningitis. Literature cited in this work illustrates that immune state and other biologic mediator imbalances due to various endogenous and exogenous triggering factors may markedly affect latent central nervous system T. gondii infection/inflammation intensity, and cause reactivation of cerebral toxoplasmosis (CT). Irregularities in pro- and anti-inflammatory processes may markedly disturb the host and/or T. gondii defense mechanisms important for immune control of the parasite thereby manifesting as a wide range of neurologic symptoms and signs observed in some patients with migraine, epilepsy, celiac disease, Henoch-Schonlein purpura, and other brain disorders. This is consistent with reactivation of CT in mice after treatment with dexamethasone associated with depression of type TH1 immune response, and development of CT after administration of etanercept or other bioproducts. It seems that various types of headaches, epilepsy, aseptic meningitis, systemic adverse reactions to drugs or other substances represent the Jarisch-Herxheimer reaction due to apoptosis of T. gondii tachyzoites. Also development of some brain tumors, such as ependymoma and glioma may be associated with a chronic course of CT. Thus, all these patients should be tested for T. gondii infection. [ABSTRACT FROM AUTHOR] |
| Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 44873945 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The Importance of Toxoplasma Gondii Infection in Diseases Presenting with Headaches. Headaches and Aseptic Meningitis May be Manifestations of the Jarisch-Herxheimer Reaction. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22PRANDOTA%2C+JOSEPH%22">PRANDOTA, JOSEPH</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22International+Journal+of+Neuroscience%22">International Journal of Neuroscience</searchLink>. Dec2009, Vol. 119 Issue 12, p2144-2182. 39p. 6 Charts. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Brain+tumors%22">Brain tumors</searchLink><br /><searchLink fieldCode="DE" term="%22Celiac+disease%22">Celiac disease</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebral+toxoplasmosis%22">Cerebral toxoplasmosis</searchLink><br /><searchLink fieldCode="DE" term="%22Epilepsy%22">Epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Schoenlein-Henoch+purpura%22">Schoenlein-Henoch purpura</searchLink><br /><searchLink fieldCode="DE" term="%22Migraine%22">Migraine</searchLink><br /><searchLink fieldCode="DE" term="%22Meningitis%22">Meningitis</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Worldwide, approximately 2 billion people are chronically infected with T. gondii with largely unknown consequences. This review presents clinical symptoms, differential diagnosis, triggering factors, treatment, and pathomechanisms responsible for idiopathic intracranial hypertension, pseudotumor cerebri, and aseptic meningitis. Literature cited in this work illustrates that immune state and other biologic mediator imbalances due to various endogenous and exogenous triggering factors may markedly affect latent central nervous system T. gondii infection/inflammation intensity, and cause reactivation of cerebral toxoplasmosis (CT). Irregularities in pro- and anti-inflammatory processes may markedly disturb the host and/or T. gondii defense mechanisms important for immune control of the parasite thereby manifesting as a wide range of neurologic symptoms and signs observed in some patients with migraine, epilepsy, celiac disease, Henoch-Schonlein purpura, and other brain disorders. This is consistent with reactivation of CT in mice after treatment with dexamethasone associated with depression of type TH1 immune response, and development of CT after administration of etanercept or other bioproducts. It seems that various types of headaches, epilepsy, aseptic meningitis, systemic adverse reactions to drugs or other substances represent the Jarisch-Herxheimer reaction due to apoptosis of T. gondii tachyzoites. Also development of some brain tumors, such as ependymoma and glioma may be associated with a chronic course of CT. Thus, all these patients should be tested for T. gondii infection. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of International Journal of Neuroscience is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3109/00207450903149217 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 39 StartPage: 2144 Subjects: – SubjectFull: Brain tumors Type: general – SubjectFull: Celiac disease Type: general – SubjectFull: Cerebral toxoplasmosis Type: general – SubjectFull: Epilepsy Type: general – SubjectFull: Schoenlein-Henoch purpura Type: general – SubjectFull: Migraine Type: general – SubjectFull: Meningitis Type: general Titles: – TitleFull: The Importance of Toxoplasma Gondii Infection in Diseases Presenting with Headaches. Headaches and Aseptic Meningitis May be Manifestations of the Jarisch-Herxheimer Reaction. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: PRANDOTA, JOSEPH IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2009 Type: published Y: 2009 Identifiers: – Type: issn-print Value: 00207454 Numbering: – Type: volume Value: 119 – Type: issue Value: 12 Titles: – TitleFull: International Journal of Neuroscience Type: main |
| ResultId | 1 |
