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Melatonin decreases daytime challenging behaviour in persons with intellectual disability and chronic insomnia.

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Title: Melatonin decreases daytime challenging behaviour in persons with intellectual disability and chronic insomnia.
Authors: Braam, W. (AUTHOR), Didden, R. (AUTHOR), Maas, A. P. H. M. (AUTHOR), Korzilius, H. (AUTHOR), Smits, M. G. (AUTHOR), Curfs, L. M. G. (AUTHOR)
Source: Journal of Intellectual Disability Research. Jan2010, Vol. 54 Issue 1, p52-59. 8p. 1 Diagram, 2 Charts.
Subjects: Melatonin, Behavior disorders, Intellectual disabilities, Insomnia, People with intellectual disabilities
Abstract: Background Persons with intellectual disability (ID) and sleep problems exhibit more daytime challenging behaviours than persons with ID without sleep problems. Several anecdotal reports suggest that melatonin is not only effective in the treatment of insomnia, but also decreases daytime challenging behaviour. However, the effect of melatonin treatment on daytime challenging behaviour in persons with ID has not been investigated in a randomised controlled trial. Method We investigated the effects of melatonin on challenging behaviour using data from two randomised controlled trials on the efficacy of melatonin on sleep problems in 49 persons (25 men, 24 women; mean age 18.2 years, SD = 17.1) with ID and chronic insomnia. Participants received either melatonin 5 mg (<6 years 2.5 mg) or placebo during 4 weeks. Daytime challenging behaviour was measured by the Storend Gedragsschaal voor Zwakzinnigen – Maladaptive Behaviour Scale for the Mentally Retarded (SGZ; Kraijer & Kema, 1994 ) at baseline week and the end of the fourth treatment week. Salivary dim light melatonin onset (DLMO) was measured at baseline and the last day of the fourth treatment week. Sleep logs were used to gather information on sleep parameters. Results Melatonin treatment significantly reduced SGZ scores, sleep latency, and number and duration of night wakes, and treatment increased total sleep time and advanced DLMO. However, after 4 weeks of treatment, change in SGZ scores did not significantly correlate with change in sleep parameters, nor with change in DLMO. Relatively strong correlations were found between change in SGZ scores, change in DLMO and number of night wakes. Conclusions Melatonin treatment in persons with ID and chronic insomnia decreases daytime challenging behaviour, probably by improving sleep maintenance or by improving circadian melatonin rhythmicity. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Intellectual Disability Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Melatonin decreases daytime challenging behaviour in persons with intellectual disability and chronic insomnia.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Braam%2C+W%2E%22&quot;&gt;Braam, W.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Didden%2C+R%2E%22&quot;&gt;Didden, R.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Maas%2C+A%2E+P%2E+H%2E+M%2E%22&quot;&gt;Maas, A. P. H. M.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Korzilius%2C+H%2E%22&quot;&gt;Korzilius, H.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Smits%2C+M%2E+G%2E%22&quot;&gt;Smits, M. G.&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Curfs%2C+L%2E+M%2E+G%2E%22&quot;&gt;Curfs, L. M. G.&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Journal+of+Intellectual+Disability+Research%22&quot;&gt;Journal of Intellectual Disability Research&lt;/searchLink&gt;. Jan2010, Vol. 54 Issue 1, p52-59. 8p. 1 Diagram, 2 Charts.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Melatonin%22&quot;&gt;Melatonin&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Behavior+disorders%22&quot;&gt;Behavior disorders&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Intellectual+disabilities%22&quot;&gt;Intellectual disabilities&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Insomnia%22&quot;&gt;Insomnia&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22People+with+intellectual+disabilities%22&quot;&gt;People with intellectual disabilities&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
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  Data: Background Persons with intellectual disability (ID) and sleep problems exhibit more daytime challenging behaviours than persons with ID without sleep problems. Several anecdotal reports suggest that melatonin is not only effective in the treatment of insomnia, but also decreases daytime challenging behaviour. However, the effect of melatonin treatment on daytime challenging behaviour in persons with ID has not been investigated in a randomised controlled trial. Method We investigated the effects of melatonin on challenging behaviour using data from two randomised controlled trials on the efficacy of melatonin on sleep problems in 49 persons (25 men, 24 women; mean age 18.2 years, SD = 17.1) with ID and chronic insomnia. Participants received either melatonin 5 mg (&lt;6 years 2.5 mg) or placebo during 4 weeks. Daytime challenging behaviour was measured by the Storend Gedragsschaal voor Zwakzinnigen – Maladaptive Behaviour Scale for the Mentally Retarded (SGZ; Kraijer &amp; Kema, 1994 ) at baseline week and the end of the fourth treatment week. Salivary dim light melatonin onset (DLMO) was measured at baseline and the last day of the fourth treatment week. Sleep logs were used to gather information on sleep parameters. Results Melatonin treatment significantly reduced SGZ scores, sleep latency, and number and duration of night wakes, and treatment increased total sleep time and advanced DLMO. However, after 4 weeks of treatment, change in SGZ scores did not significantly correlate with change in sleep parameters, nor with change in DLMO. Relatively strong correlations were found between change in SGZ scores, change in DLMO and number of night wakes. Conclusions Melatonin treatment in persons with ID and chronic insomnia decreases daytime challenging behaviour, probably by improving sleep maintenance or by improving circadian melatonin rhythmicity. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of Journal of Intellectual Disability Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1111/j.1365-2788.2009.01223.x
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      – Code: eng
        Text: English
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        PageCount: 8
        StartPage: 52
    Subjects:
      – SubjectFull: Melatonin
        Type: general
      – SubjectFull: Behavior disorders
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      – SubjectFull: Intellectual disabilities
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      – SubjectFull: Insomnia
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      – SubjectFull: People with intellectual disabilities
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              Text: Jan2010
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