Plaque Morphology in Carotid Stenosis is a Risk Factor for Ischemic Cerebrovascular Events.
Saved in:
| Title: | Plaque Morphology in Carotid Stenosis is a Risk Factor for Ischemic Cerebrovascular Events. |
|---|---|
| Authors: | Mathiesen*†, Ellisiv B., Bønaa, Kaare H., Joakimsen†, Oddmund |
| Source: | Acta Neurologica Scandinavica. May2001, Vol. 103 Issue 5, p327. 7p. |
| Subjects: | Carotid artery diseases, Arterial stenosis, Coronary disease |
| Abstract: | Purpose: To assess in a prospective, population-based design whether plaque morphology is associated with increased risk of ischemic stroke and other cerebrovascular events in subjects with carotid stenosis. Methods: A total of 223 subjects with carotid stenosis and 215 controls matched by age and sex who participated in a population health survey were followed up for 3 years. At baseline, plaque morphology and degree of stenosis were assessed by ultrasound, and information on risk factors was obtained. Plaque echogenicity was scored as echolucent, predominantly echolucent, predominantly echogenic, or echogenic. Results: Forty-four subjects experienced one or more ischemic cerebrovascular events in the follow-up period. Plaque echogenicity, degree of stenosis, and white blood cell count were independent predictors of cerebrovascular events. The unadjusted relative risk for cerebrovascular events was 12.98 in subjects with echolucent plaques (95% confidence interval [CI] 4.50-37.43), and in subjects with echogenic plaques 3.67 (95% CI 0.74-18.21) when subjects without stenosis were used as the reference. When adjustments were made for age, sex, degree of stenosis and cardiovascular risk factors, the relative risk for cerebrovascular events in subjects with echolucent plaques was 4.21 (95% CI 1.01-17.63), and there was a significant linear trend (p=0.02) for higher risk with increasing plaque echolucency. Conclusions: Subjects with echolucent atherosclerotic plaques have increased risk of ischemic cerebrovascular events independent of degree of stenosis and cardiovascular risk factors. Subjects with high risk of ischemic vascular events may be identified by ultrasound assessment of plaque morphology. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 4592365 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Plaque Morphology in Carotid Stenosis is a Risk Factor for Ischemic Cerebrovascular Events. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Mathiesen*†%2C+Ellisiv+B%2E%22">Mathiesen*†, Ellisiv B.</searchLink><br /><searchLink fieldCode="AR" term="%22Bønaa%2C+Kaare+H%2E%22">Bønaa, Kaare H.</searchLink><br /><searchLink fieldCode="AR" term="%22Joakimsen†%2C+Oddmund%22">Joakimsen†, Oddmund</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Neurologica+Scandinavica%22">Acta Neurologica Scandinavica</searchLink>. May2001, Vol. 103 Issue 5, p327. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Carotid+artery+diseases%22">Carotid artery diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Arterial+stenosis%22">Arterial stenosis</searchLink><br /><searchLink fieldCode="DE" term="%22Coronary+disease%22">Coronary disease</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: To assess in a prospective, population-based design whether plaque morphology is associated with increased risk of ischemic stroke and other cerebrovascular events in subjects with carotid stenosis. Methods: A total of 223 subjects with carotid stenosis and 215 controls matched by age and sex who participated in a population health survey were followed up for 3 years. At baseline, plaque morphology and degree of stenosis were assessed by ultrasound, and information on risk factors was obtained. Plaque echogenicity was scored as echolucent, predominantly echolucent, predominantly echogenic, or echogenic. Results: Forty-four subjects experienced one or more ischemic cerebrovascular events in the follow-up period. Plaque echogenicity, degree of stenosis, and white blood cell count were independent predictors of cerebrovascular events. The unadjusted relative risk for cerebrovascular events was 12.98 in subjects with echolucent plaques (95% confidence interval [CI] 4.50-37.43), and in subjects with echogenic plaques 3.67 (95% CI 0.74-18.21) when subjects without stenosis were used as the reference. When adjustments were made for age, sex, degree of stenosis and cardiovascular risk factors, the relative risk for cerebrovascular events in subjects with echolucent plaques was 4.21 (95% CI 1.01-17.63), and there was a significant linear trend (p=0.02) for higher risk with increasing plaque echolucency. Conclusions: Subjects with echolucent atherosclerotic plaques have increased risk of ischemic cerebrovascular events independent of degree of stenosis and cardiovascular risk factors. Subjects with high risk of ischemic vascular events may be identified by ultrasound assessment of plaque morphology. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Neurologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=4592365 |
| RecordInfo | BibRecord: BibEntity: Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 327 Subjects: – SubjectFull: Carotid artery diseases Type: general – SubjectFull: Arterial stenosis Type: general – SubjectFull: Coronary disease Type: general Titles: – TitleFull: Plaque Morphology in Carotid Stenosis is a Risk Factor for Ischemic Cerebrovascular Events. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Mathiesen*†, Ellisiv B. – PersonEntity: Name: NameFull: Bønaa, Kaare H. – PersonEntity: Name: NameFull: Joakimsen†, Oddmund IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2001 Type: published Y: 2001 Identifiers: – Type: issn-print Value: 00016314 Numbering: – Type: volume Value: 103 – Type: issue Value: 5 Titles: – TitleFull: Acta Neurologica Scandinavica Type: main |
| ResultId | 1 |
