The effects of 3-week estrogen hormone replacement on cognition in elderly healthy females.
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| Title: | The effects of 3-week estrogen hormone replacement on cognition in elderly healthy females. |
|---|---|
| Authors: | Duka, T., Tasker, R., McGowan, J. F. |
| Source: | Psychopharmacology. 2000, Vol. 149 Issue 2, p129. 11p. |
| Subjects: | Estrogen replacement therapy, Older women, Hormone therapy for menopause, Estradiol, Mental health, Therapeutics |
| Abstract: | Abstract Rationale: Estrogen concentrations decline with age and menopause is often followed by an acceleration of the age effects on cognition. It is suggested that replacement of estrogen would reinstate, at least in part, cognitive abilities. Effects of estrogens on memory have been reported in studies with women in a clinical setting who either needed or wished to have the estrogen replacement and are mostly in the perimenopausal ageband. Objective: The present study investigated the effects of estradiol on memory and on frontal lobe function in elderly female subjects who did not suffer any of the postmenopausal symptoms and had never taken estrogen hormone replacement (EHR) previously. Methods: EHR (Progynova TS, transdermal estradiol; n=19) or placebo (n=18) was given for a period of 3 weeks to elderly healthy female subjects. Memory, frontal lobe functions (inhibition and planning) and visuospatial abilities (mental rotation) were tested before and after treatment. Estrogen plasma levels were measured to confirm the result of EHR. Cortisol plasma levels were also measured before and after cognitive performance in order to evaluate the effects of EHR on the sensitivity of the hypothalamo-pituitary-adrenal (HPA) axis to mild mental stress. Results: Plasma estradiol levels in the drug group increased to levels equivalent to that of a fertile woman (0.21 +/0.5 nmol/1). Memory function as well as visuospatial abilities as measured by a mental rotation task improved significantly with EHR. However, there was no effect of EHR on frontal lobe functions. The cognitive effects were not dependent on an improvement in mood or general well-being as may be the case with EHR in women at peri- or post-menopausal stage. EHR was found to increase the HPA response to... [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 4693566 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The effects of 3-week estrogen hormone replacement on cognition in elderly healthy females. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Duka%2C+T%2E%22">Duka, T.</searchLink><br /><searchLink fieldCode="AR" term="%22Tasker%2C+R%2E%22">Tasker, R.</searchLink><br /><searchLink fieldCode="AR" term="%22McGowan%2C+J%2E+F%2E%22">McGowan, J. F.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. 2000, Vol. 149 Issue 2, p129. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Estrogen+replacement+therapy%22">Estrogen replacement therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Older+women%22">Older women</searchLink><br /><searchLink fieldCode="DE" term="%22Hormone+therapy+for+menopause%22">Hormone therapy for menopause</searchLink><br /><searchLink fieldCode="DE" term="%22Estradiol%22">Estradiol</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+health%22">Mental health</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract Rationale: Estrogen concentrations decline with age and menopause is often followed by an acceleration of the age effects on cognition. It is suggested that replacement of estrogen would reinstate, at least in part, cognitive abilities. Effects of estrogens on memory have been reported in studies with women in a clinical setting who either needed or wished to have the estrogen replacement and are mostly in the perimenopausal ageband. Objective: The present study investigated the effects of estradiol on memory and on frontal lobe function in elderly female subjects who did not suffer any of the postmenopausal symptoms and had never taken estrogen hormone replacement (EHR) previously. Methods: EHR (Progynova TS, transdermal estradiol; n=19) or placebo (n=18) was given for a period of 3 weeks to elderly healthy female subjects. Memory, frontal lobe functions (inhibition and planning) and visuospatial abilities (mental rotation) were tested before and after treatment. Estrogen plasma levels were measured to confirm the result of EHR. Cortisol plasma levels were also measured before and after cognitive performance in order to evaluate the effects of EHR on the sensitivity of the hypothalamo-pituitary-adrenal (HPA) axis to mild mental stress. Results: Plasma estradiol levels in the drug group increased to levels equivalent to that of a fertile woman (0.21 +/0.5 nmol/1). Memory function as well as visuospatial abilities as measured by a mental rotation task improved significantly with EHR. However, there was no effect of EHR on frontal lobe functions. The cognitive effects were not dependent on an improvement in mood or general well-being as may be the case with EHR in women at peri- or post-menopausal stage. EHR was found to increase the HPA response to... [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s002139900324 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 129 Subjects: – SubjectFull: Estrogen replacement therapy Type: general – SubjectFull: Older women Type: general – SubjectFull: Hormone therapy for menopause Type: general – SubjectFull: Estradiol Type: general – SubjectFull: Mental health Type: general – SubjectFull: Therapeutics Type: general Titles: – TitleFull: The effects of 3-week estrogen hormone replacement on cognition in elderly healthy females. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Duka, T. – PersonEntity: Name: NameFull: Tasker, R. – PersonEntity: Name: NameFull: McGowan, J. F. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: 2000 Type: published Y: 2000 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 149 – Type: issue Value: 2 Titles: – TitleFull: Psychopharmacology Type: main |
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