Effect of histamine H[sub 2] and H[sub 3] receptor modulation in the septum on post-training memory processing.
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| Title: | Effect of histamine H[sub 2] and H[sub 3] receptor modulation in the septum on post-training memory processing. |
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| Authors: | Flood, James F., Uezu, Kayoko, Morley, John E. |
| Source: | Psychopharmacology. 1998, Vol. 140 Issue 3, p279. 6p. |
| Subjects: | Histamine receptors, Autoreceptors, Septum (Brain), Mice, Drugs |
| Abstract: | Abstract We compared the effects of modulating the postsynaptic histamine receptor subtype 2 (H[sub 2]) and inhibitory presynaptic autoreceptor subtype 3 (H[sub 3]) on memory processing in the septum. Mice were partially trained on footshock avoidance in a T-maze. Immediately after training, saline or a drug solution was infused into the septum. One week later, retention was tested by continuing training until the mice made five avoidance responses in six consecutive trials. The results indicate that dimaprit, an H[sub 2] agonist, facilitated retention (25 and 50 pg) with a U-shaped dose-response curve typical of drugs acting at postsynaptic receptors. Cimetidine, an H[sub 2] antagonist, impaired retention (15-50 ng). The H[sub 3] agonist, imetit, impaired retention (25-200 ng), while the H[sub 3] antagonist, thioperamide, facilitated retention (10-400 ng). An unusual feature of the dose-response curve for thioperamide was that it did not appear to yield a U-shaped curve as occurs with drugs acting postsynaptically, but facilitated retention to approximately the same degree from 50 to 400 ng. As histamine neurons project to various limbic system structures involved in memory processing, it may play an important role in regulating the activity of structures such as the septum, hippocampus and amygdala. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 4693711 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effect of histamine H[sub 2] and H[sub 3] receptor modulation in the septum on post-training memory processing. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Flood%2C+James+F%2E%22">Flood, James F.</searchLink><br /><searchLink fieldCode="AR" term="%22Uezu%2C+Kayoko%22">Uezu, Kayoko</searchLink><br /><searchLink fieldCode="AR" term="%22Morley%2C+John+E%2E%22">Morley, John E.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. 1998, Vol. 140 Issue 3, p279. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Histamine+receptors%22">Histamine receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Autoreceptors%22">Autoreceptors</searchLink><br /><searchLink fieldCode="DE" term="%22Septum+%28Brain%29%22">Septum (Brain)</searchLink><br /><searchLink fieldCode="DE" term="%22Mice%22">Mice</searchLink><br /><searchLink fieldCode="DE" term="%22Drugs%22">Drugs</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract We compared the effects of modulating the postsynaptic histamine receptor subtype 2 (H[sub 2]) and inhibitory presynaptic autoreceptor subtype 3 (H[sub 3]) on memory processing in the septum. Mice were partially trained on footshock avoidance in a T-maze. Immediately after training, saline or a drug solution was infused into the septum. One week later, retention was tested by continuing training until the mice made five avoidance responses in six consecutive trials. The results indicate that dimaprit, an H[sub 2] agonist, facilitated retention (25 and 50 pg) with a U-shaped dose-response curve typical of drugs acting at postsynaptic receptors. Cimetidine, an H[sub 2] antagonist, impaired retention (15-50 ng). The H[sub 3] agonist, imetit, impaired retention (25-200 ng), while the H[sub 3] antagonist, thioperamide, facilitated retention (10-400 ng). An unusual feature of the dose-response curve for thioperamide was that it did not appear to yield a U-shaped curve as occurs with drugs acting postsynaptically, but facilitated retention to approximately the same degree from 50 to 400 ng. As histamine neurons project to various limbic system structures involved in memory processing, it may play an important role in regulating the activity of structures such as the septum, hippocampus and amygdala. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s002130050768 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 279 Subjects: – SubjectFull: Histamine receptors Type: general – SubjectFull: Autoreceptors Type: general – SubjectFull: Septum (Brain) Type: general – SubjectFull: Mice Type: general – SubjectFull: Drugs Type: general Titles: – TitleFull: Effect of histamine H[sub 2] and H[sub 3] receptor modulation in the septum on post-training memory processing. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Flood, James F. – PersonEntity: Name: NameFull: Uezu, Kayoko – PersonEntity: Name: NameFull: Morley, John E. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: 1998 Type: published Y: 1998 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 140 – Type: issue Value: 3 Titles: – TitleFull: Psychopharmacology Type: main |
| ResultId | 1 |
