Bibliographic Details
| Title: |
SSRI treatment decreases prolactin and hyperthermic responses to mCPP. |
| Authors: |
Quested, D. J., Sargent, P. A., Cowen, P. J. |
| Source: |
Psychopharmacology. 1997, Vol. 133 Issue 3, p305. 4p. |
| Subjects: |
Serotonin uptake inhibitors, Serotonin, Prolactin, Physiology |
| Abstract: |
Abstract We studied the effect of 3 weeks treatment with the selective serotonin re-uptake inhibitor (SSRI), paroxetine (30 mg daily), on the neuroendocrine and hyperthermic responses to the 5-HT[sub 2C] receptor agonist, m-chlorophenylpiperazine (mCPP) (0.05 mg/kg IV), in seven healthy volunteers. Following paroxetine treatment, both the prolactin and hyperthermic responses to mCPP were significantly attenuated. These data are consistent with experimental animal studies indicating that repeated SSRI treatment leads to a functional desensitisation of 5-HT[sub 2C] receptors. This effect may be linked to the anxiolytic properties of SSRIs. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
