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SSRI treatment decreases prolactin and hyperthermic responses to mCPP.

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Title: SSRI treatment decreases prolactin and hyperthermic responses to mCPP.
Authors: Quested, D. J., Sargent, P. A., Cowen, P. J.
Source: Psychopharmacology. 1997, Vol. 133 Issue 3, p305. 4p.
Subjects: Serotonin uptake inhibitors, Serotonin, Prolactin, Physiology
Abstract: Abstract We studied the effect of 3 weeks treatment with the selective serotonin re-uptake inhibitor (SSRI), paroxetine (30 mg daily), on the neuroendocrine and hyperthermic responses to the 5-HT[sub 2C] receptor agonist, m-chlorophenylpiperazine (mCPP) (0.05 mg/kg IV), in seven healthy volunteers. Following paroxetine treatment, both the prolactin and hyperthermic responses to mCPP were significantly attenuated. These data are consistent with experimental animal studies indicating that repeated SSRI treatment leads to a functional desensitisation of 5-HT[sub 2C] receptors. This effect may be linked to the anxiolytic properties of SSRIs. [ABSTRACT FROM AUTHOR]
Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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PubType: Academic Journal
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  Data: SSRI treatment decreases prolactin and hyperthermic responses to mCPP.
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  Data: <searchLink fieldCode="AR" term="%22Quested%2C+D%2E+J%2E%22">Quested, D. J.</searchLink><br /><searchLink fieldCode="AR" term="%22Sargent%2C+P%2E+A%2E%22">Sargent, P. A.</searchLink><br /><searchLink fieldCode="AR" term="%22Cowen%2C+P%2E+J%2E%22">Cowen, P. J.</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. 1997, Vol. 133 Issue 3, p305. 4p.
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  Data: <searchLink fieldCode="DE" term="%22Serotonin+uptake+inhibitors%22">Serotonin uptake inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22Serotonin%22">Serotonin</searchLink><br /><searchLink fieldCode="DE" term="%22Prolactin%22">Prolactin</searchLink><br /><searchLink fieldCode="DE" term="%22Physiology%22">Physiology</searchLink>
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  Label: Abstract
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  Data: Abstract We studied the effect of 3 weeks treatment with the selective serotonin re-uptake inhibitor (SSRI), paroxetine (30 mg daily), on the neuroendocrine and hyperthermic responses to the 5-HT[sub 2C] receptor agonist, m-chlorophenylpiperazine (mCPP) (0.05 mg/kg IV), in seven healthy volunteers. Following paroxetine treatment, both the prolactin and hyperthermic responses to mCPP were significantly attenuated. These data are consistent with experimental animal studies indicating that repeated SSRI treatment leads to a functional desensitisation of 5-HT[sub 2C] receptors. This effect may be linked to the anxiolytic properties of SSRIs. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s002130050406
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      – SubjectFull: Prolactin
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      – TitleFull: SSRI treatment decreases prolactin and hyperthermic responses to mCPP.
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              Text: 1997
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