An active metabolite of carbamazepine, carbamazepine-10,11-epoxide, inhibits ion channel-mediated catecholamine secretion in cultured bovine adrenal medullary cells.
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| Title: | An active metabolite of carbamazepine, carbamazepine-10,11-epoxide, inhibits ion channel-mediated catecholamine secretion in cultured bovine adrenal medullary cells. |
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| Authors: | Yoshimura, Reiji, Yanagihara, N., Terao, Takeshi, Minami, Kouichiro, Toyohira, Yumiko, Ueno, Susumu, Uezono, Yasuhito, Abe, Kazuhiko, Izumi, Futoshi |
| Source: | Psychopharmacology. 1998, Vol. 135 Issue 4, p368. 6p. |
| Subjects: | Carbamazepine, Ion channels, Catecholamines, Cholinergic receptors, Physiology |
| Abstract: | Abstract We have recently reported inhibitory effects of carbamazepine (CBZ) on ion channel-mediated secretion of catecholamines in bovine adrenal medullary cells. Here, we report the effects of carbamazepine 10,11-epoxide (CBZ-E), an active metabolite of CBZ, and carbamazepine-10,11-diol (CBZ-D), a non-active metabolite, on [sup 22]Na[sup +] influx, [sup 45]Ca[sup 2+] influx and catecholamine secretion in cultured adrenal medullary cells. CBZ-E, but not CBZ-D inhibited [sup 22]Na[sub +] influx, [sup 45]Ca[sup 2+] influx and catecholamine secretion induced by carbachol or veratridine with a half-maximal inhibitory concentration (IC[sub 50]) of 0.26 or 0.68 mug/ml, respectively. CBZ-E also inhibited high K[sup +]-evoked [sup 45]Ca[sub 2+] influx and catecholamine secretion (IC[sub 50] = 0.3 mug/ml), but CBZ-D did not. These findings suggest that CBZ-E, but not CBZ-D, attenuates catecholamine secretion by inhibiting nicotinic acetylcholine receptor-associated ion channels, voltage-dependent Na[sup +] channels and voltage-dependent Ca[sup 2+] channels in the cells. This inhibition... [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 4694424 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: An active metabolite of carbamazepine, carbamazepine-10,11-epoxide, inhibits ion channel-mediated catecholamine secretion in cultured bovine adrenal medullary cells. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Yoshimura%2C+Reiji%22">Yoshimura, Reiji</searchLink><br /><searchLink fieldCode="AR" term="%22Yanagihara%2C+N%2E%22">Yanagihara, N.</searchLink><br /><searchLink fieldCode="AR" term="%22Terao%2C+Takeshi%22">Terao, Takeshi</searchLink><br /><searchLink fieldCode="AR" term="%22Minami%2C+Kouichiro%22">Minami, Kouichiro</searchLink><br /><searchLink fieldCode="AR" term="%22Toyohira%2C+Yumiko%22">Toyohira, Yumiko</searchLink><br /><searchLink fieldCode="AR" term="%22Ueno%2C+Susumu%22">Ueno, Susumu</searchLink><br /><searchLink fieldCode="AR" term="%22Uezono%2C+Yasuhito%22">Uezono, Yasuhito</searchLink><br /><searchLink fieldCode="AR" term="%22Abe%2C+Kazuhiko%22">Abe, Kazuhiko</searchLink><br /><searchLink fieldCode="AR" term="%22Izumi%2C+Futoshi%22">Izumi, Futoshi</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. 1998, Vol. 135 Issue 4, p368. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Carbamazepine%22">Carbamazepine</searchLink><br /><searchLink fieldCode="DE" term="%22Ion+channels%22">Ion channels</searchLink><br /><searchLink fieldCode="DE" term="%22Catecholamines%22">Catecholamines</searchLink><br /><searchLink fieldCode="DE" term="%22Cholinergic+receptors%22">Cholinergic receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Physiology%22">Physiology</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract We have recently reported inhibitory effects of carbamazepine (CBZ) on ion channel-mediated secretion of catecholamines in bovine adrenal medullary cells. Here, we report the effects of carbamazepine 10,11-epoxide (CBZ-E), an active metabolite of CBZ, and carbamazepine-10,11-diol (CBZ-D), a non-active metabolite, on [sup 22]Na[sup +] influx, [sup 45]Ca[sup 2+] influx and catecholamine secretion in cultured adrenal medullary cells. CBZ-E, but not CBZ-D inhibited [sup 22]Na[sub +] influx, [sup 45]Ca[sup 2+] influx and catecholamine secretion induced by carbachol or veratridine with a half-maximal inhibitory concentration (IC[sub 50]) of 0.26 or 0.68 mug/ml, respectively. CBZ-E also inhibited high K[sup +]-evoked [sup 45]Ca[sub 2+] influx and catecholamine secretion (IC[sub 50] = 0.3 mug/ml), but CBZ-D did not. These findings suggest that CBZ-E, but not CBZ-D, attenuates catecholamine secretion by inhibiting nicotinic acetylcholine receptor-associated ion channels, voltage-dependent Na[sup +] channels and voltage-dependent Ca[sup 2+] channels in the cells. This inhibition... [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s002130050524 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 368 Subjects: – SubjectFull: Carbamazepine Type: general – SubjectFull: Ion channels Type: general – SubjectFull: Catecholamines Type: general – SubjectFull: Cholinergic receptors Type: general – SubjectFull: Physiology Type: general Titles: – TitleFull: An active metabolite of carbamazepine, carbamazepine-10,11-epoxide, inhibits ion channel-mediated catecholamine secretion in cultured bovine adrenal medullary cells. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Yoshimura, Reiji – PersonEntity: Name: NameFull: Yanagihara, N. – PersonEntity: Name: NameFull: Terao, Takeshi – PersonEntity: Name: NameFull: Minami, Kouichiro – PersonEntity: Name: NameFull: Toyohira, Yumiko – PersonEntity: Name: NameFull: Ueno, Susumu – PersonEntity: Name: NameFull: Uezono, Yasuhito – PersonEntity: Name: NameFull: Abe, Kazuhiko – PersonEntity: Name: NameFull: Izumi, Futoshi IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 02 Text: 1998 Type: published Y: 1998 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 135 – Type: issue Value: 4 Titles: – TitleFull: Psychopharmacology Type: main |
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