Effects of cotinine on information processing in nonsmokers.
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| Title: | Effects of cotinine on information processing in nonsmokers. |
|---|---|
| Authors: | Herzig, Karen E., Callaway, Enoch, Halliday, R., Naylor, Hilary, Benowitz, Neal L. |
| Source: | Psychopharmacology. 1998, Vol. 135 Issue 2, p127. 6p. |
| Subjects: | Nicotine, Human information processing, Evoked potentials (Electrophysiology), Reaction time, Physiology |
| Abstract: | Abstract Cotinine, the major proximate metabolite of nicotine, is present in smokers in higher concentrations and for a longer time than nicotine, yet its effects on information processing have not previously been reported. We studied the cognitive effects of cotinine in non-smokers. Sixteen subjects were tested on three doses of cotinine (0.5, 1.0, and 1.5mg cotinine base/kg), and placebo, on a choice reaction time (RT) task and on a verbal recall task with short and long lists. Cotinine significantly impaired recall on the long list and displayed non-significant but generally consistent dose-related slowing of RT and N100 latency. The acute effects of cotinine were small, and probably do not account for the cognitive deficits observed in tobacco withdrawal, although the cognitive effects of chronic cotinine administration need to be investigated. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 4694485 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Effects of cotinine on information processing in nonsmokers. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Herzig%2C+Karen+E%2E%22">Herzig, Karen E.</searchLink><br /><searchLink fieldCode="AR" term="%22Callaway%2C+Enoch%22">Callaway, Enoch</searchLink><br /><searchLink fieldCode="AR" term="%22Halliday%2C+R%2E%22">Halliday, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Naylor%2C+Hilary%22">Naylor, Hilary</searchLink><br /><searchLink fieldCode="AR" term="%22Benowitz%2C+Neal+L%2E%22">Benowitz, Neal L.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. 1998, Vol. 135 Issue 2, p127. 6p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Nicotine%22">Nicotine</searchLink><br /><searchLink fieldCode="DE" term="%22Human+information+processing%22">Human information processing</searchLink><br /><searchLink fieldCode="DE" term="%22Evoked+potentials+%28Electrophysiology%29%22">Evoked potentials (Electrophysiology)</searchLink><br /><searchLink fieldCode="DE" term="%22Reaction+time%22">Reaction time</searchLink><br /><searchLink fieldCode="DE" term="%22Physiology%22">Physiology</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract Cotinine, the major proximate metabolite of nicotine, is present in smokers in higher concentrations and for a longer time than nicotine, yet its effects on information processing have not previously been reported. We studied the cognitive effects of cotinine in non-smokers. Sixteen subjects were tested on three doses of cotinine (0.5, 1.0, and 1.5mg cotinine base/kg), and placebo, on a choice reaction time (RT) task and on a verbal recall task with short and long lists. Cotinine significantly impaired recall on the long list and displayed non-significant but generally consistent dose-related slowing of RT and N100 latency. The acute effects of cotinine were small, and probably do not account for the cognitive deficits observed in tobacco withdrawal, although the cognitive effects of chronic cotinine administration need to be investigated. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s002130050493 Languages: – Code: zul Text: Zulu PhysicalDescription: Pagination: PageCount: 6 StartPage: 127 Subjects: – SubjectFull: Nicotine Type: general – SubjectFull: Human information processing Type: general – SubjectFull: Evoked potentials (Electrophysiology) Type: general – SubjectFull: Reaction time Type: general – SubjectFull: Physiology Type: general Titles: – TitleFull: Effects of cotinine on information processing in nonsmokers. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Herzig, Karen E. – PersonEntity: Name: NameFull: Callaway, Enoch – PersonEntity: Name: NameFull: Halliday, R. – PersonEntity: Name: NameFull: Naylor, Hilary – PersonEntity: Name: NameFull: Benowitz, Neal L. IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 01 Text: 1998 Type: published Y: 1998 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 135 – Type: issue Value: 2 Titles: – TitleFull: Psychopharmacology Type: main |
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