The effect of m-CPP on tics and obsessive-compulsive phenomena in Gilles de la Tourette syndrome.
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| Title: | The effect of m-CPP on tics and obsessive-compulsive phenomena in Gilles de la Tourette syndrome. |
|---|---|
| Authors: | Cath, D. C., Gijsman, Harm J., Schoemaker, Rik C., van Griensven, Jean M. T., Troost, Nancy, van Kempen, Godfried M. J., Cohen, Adam F. |
| Source: | Psychopharmacology. 1999, Vol. 144 Issue 2, p137. 7p. |
| Subjects: | Tourette syndrome, Obsessive-compulsive disorder, Serotoninergic mechanisms |
| Abstract: | Abstract Rationale: Family genetic and phenomenological studies support an interrelationship between Gilles de la Tourette syndrome (GTS) and obsessive-compulsive disorder (OCD). Some authors consider GTS as part of a serotonergically mediated cluster of OCD spectrum disorders. Objective: To study serotonergic mechanisms in GTS, the effect of the relatively selective 5-HT[sub 2c] agonist meta-chlorophenylpiperazine (m-CPP) was assessed. Methods: We studied the behavioural effects of m-CPP on tics, obsessions, compulsions and impulsions of GTS. Twelve medication-free GTS patients (ten men, two women) were included in a single dose 0.5 mg/kg oral m-CPP challenge study with a double-blinded placebo-controlled cross-over design. Global symptom scores, target symptom scores as well as biochemical measures were followed up to 24 h after baseline. Results: While m-CPP caused a significant rise in plasma cortisol and prolactin levels, no significant effects were found on the tics, obsessions and compulsions. Impulsions showed a trend to ameliorate. Conclusions: This study does not support a predominant role for 5-HT on the tics in GTS. The trend of impulsions to ameliorate after m-CPP can be interpreted as circumstantial support for impulsivity-related 5-HT hypofunctionality in GTS. However, the large variability of m-CPP plasma concentrations found in this study casts doubts upon the reliability of m-CPP as a probe for challenge studies. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 4694552 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: The effect of m-CPP on tics and obsessive-compulsive phenomena in Gilles de la Tourette syndrome. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Cath%2C+D%2E+C%2E%22">Cath, D. C.</searchLink><br /><searchLink fieldCode="AR" term="%22Gijsman%2C+Harm+J%2E%22">Gijsman, Harm J.</searchLink><br /><searchLink fieldCode="AR" term="%22Schoemaker%2C+Rik+C%2E%22">Schoemaker, Rik C.</searchLink><br /><searchLink fieldCode="AR" term="%22van+Griensven%2C+Jean+M%2E+T%2E%22">van Griensven, Jean M. T.</searchLink><br /><searchLink fieldCode="AR" term="%22Troost%2C+Nancy%22">Troost, Nancy</searchLink><br /><searchLink fieldCode="AR" term="%22van+Kempen%2C+Godfried+M%2E+J%2E%22">van Kempen, Godfried M. J.</searchLink><br /><searchLink fieldCode="AR" term="%22Cohen%2C+Adam+F%2E%22">Cohen, Adam F.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. 1999, Vol. 144 Issue 2, p137. 7p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Tourette+syndrome%22">Tourette syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Obsessive-compulsive+disorder%22">Obsessive-compulsive disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Serotoninergic+mechanisms%22">Serotoninergic mechanisms</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract Rationale: Family genetic and phenomenological studies support an interrelationship between Gilles de la Tourette syndrome (GTS) and obsessive-compulsive disorder (OCD). Some authors consider GTS as part of a serotonergically mediated cluster of OCD spectrum disorders. Objective: To study serotonergic mechanisms in GTS, the effect of the relatively selective 5-HT[sub 2c] agonist meta-chlorophenylpiperazine (m-CPP) was assessed. Methods: We studied the behavioural effects of m-CPP on tics, obsessions, compulsions and impulsions of GTS. Twelve medication-free GTS patients (ten men, two women) were included in a single dose 0.5 mg/kg oral m-CPP challenge study with a double-blinded placebo-controlled cross-over design. Global symptom scores, target symptom scores as well as biochemical measures were followed up to 24 h after baseline. Results: While m-CPP caused a significant rise in plasma cortisol and prolactin levels, no significant effects were found on the tics, obsessions and compulsions. Impulsions showed a trend to ameliorate. Conclusions: This study does not support a predominant role for 5-HT on the tics in GTS. The trend of impulsions to ameliorate after m-CPP can be interpreted as circumstantial support for impulsivity-related 5-HT hypofunctionality in GTS. However, the large variability of m-CPP plasma concentrations found in this study casts doubts upon the reliability of m-CPP as a probe for challenge studies. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s002130050986 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 137 Subjects: – SubjectFull: Tourette syndrome Type: general – SubjectFull: Obsessive-compulsive disorder Type: general – SubjectFull: Serotoninergic mechanisms Type: general Titles: – TitleFull: The effect of m-CPP on tics and obsessive-compulsive phenomena in Gilles de la Tourette syndrome. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Cath, D. C. – PersonEntity: Name: NameFull: Gijsman, Harm J. – PersonEntity: Name: NameFull: Schoemaker, Rik C. – PersonEntity: Name: NameFull: van Griensven, Jean M. T. – PersonEntity: Name: NameFull: Troost, Nancy – PersonEntity: Name: NameFull: van Kempen, Godfried M. J. – PersonEntity: Name: NameFull: Cohen, Adam F. IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 07 Text: 1999 Type: published Y: 1999 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 144 – Type: issue Value: 2 Titles: – TitleFull: Psychopharmacology Type: main |
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