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Spike integration and cellular memory in a rhythmic network from Na+/K+ pump current dynamics.

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Title: Spike integration and cellular memory in a rhythmic network from Na+/K+ pump current dynamics.
Authors: Pulver, Stefan R., Griffith, Leslie C.
Source: Nature Neuroscience. Jan2010, Vol. 13 Issue 1, p53-59. 7p. 7 Graphs.
Subjects: Neural circuitry, Systemic memory hypothesis, Neuroplasticity, Drosophila, Genetics of circadian rhythms, Motor neurons, Ion channels
Abstract: The output of a neural circuit results from an interaction between the intrinsic properties of neurons in the circuit and the features of the synaptic connections between them. The plasticity of intrinsic properties has been primarily attributed to modification of ion channel function and/or number. We have found a mechanism for intrinsic plasticity in rhythmically active Drosophila neurons that was not based on changes in ion conductance. Larval motor neurons had a long-lasting, sodium-dependent afterhyperpolarization (AHP) following bursts of action potentials that was mediated by the electrogenic activity of Na+/K+ ATPase. This AHP persisted for multiple seconds following volleys of action potentials and was able to function as a pattern-insensitive integrator of spike number that was independent of external calcium. This current also interacted with endogenous Shal K+ conductances to modulate spike timing for multiple seconds following rhythmic activity, providing a cellular memory of network activity on a behaviorally relevant timescale. [ABSTRACT FROM AUTHOR]
Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Spike integration and cellular memory in a rhythmic network from Na<superscript>+</superscript>/K<superscript>+</superscript> pump current dynamics.
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  Data: <searchLink fieldCode="AR" term="%22Pulver%2C+Stefan+R%2E%22">Pulver, Stefan R.</searchLink><br /><searchLink fieldCode="AR" term="%22Griffith%2C+Leslie+C%2E%22">Griffith, Leslie C.</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Neural+circuitry%22">Neural circuitry</searchLink><br /><searchLink fieldCode="DE" term="%22Systemic+memory+hypothesis%22">Systemic memory hypothesis</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroplasticity%22">Neuroplasticity</searchLink><br /><searchLink fieldCode="DE" term="%22Drosophila%22">Drosophila</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics+of+circadian+rhythms%22">Genetics of circadian rhythms</searchLink><br /><searchLink fieldCode="DE" term="%22Motor+neurons%22">Motor neurons</searchLink><br /><searchLink fieldCode="DE" term="%22Ion+channels%22">Ion channels</searchLink>
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  Data: The output of a neural circuit results from an interaction between the intrinsic properties of neurons in the circuit and the features of the synaptic connections between them. The plasticity of intrinsic properties has been primarily attributed to modification of ion channel function and/or number. We have found a mechanism for intrinsic plasticity in rhythmically active Drosophila neurons that was not based on changes in ion conductance. Larval motor neurons had a long-lasting, sodium-dependent afterhyperpolarization (AHP) following bursts of action potentials that was mediated by the electrogenic activity of Na+/K+ ATPase. This AHP persisted for multiple seconds following volleys of action potentials and was able to function as a pattern-insensitive integrator of spike number that was independent of external calcium. This current also interacted with endogenous Shal K+ conductances to modulate spike timing for multiple seconds following rhythmic activity, providing a cellular memory of network activity on a behaviorally relevant timescale. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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