A phylogeny-driven genomic encyclopaedia of Bacteria and Archaea.
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| Title: | A phylogeny-driven genomic encyclopaedia of Bacteria and Archaea. |
|---|---|
| Authors: | Dongying Wu, Hugenholtz, Philip, Mavromatis, Konstantinos, Pukall, Rüdiger, Dalin, Eileen, Ivanova, Natalia N., Kunin, Victor, Goodwin, Lynne, Wu, Martin, Tindall, Brian J., Hooper, Sean D., Pati, Amrita, Lykidis, Athanasios, Spring, Stefan, Anderson, Iain J., D'haeseleer, Patrik, Zemla, Adam, Singer, Mitchell, Lapidus, Alla, Nolan, Matt |
| Source: | Nature. 12/24/2009, Vol. 462 Issue 7276, p1056-1060. 5p. 2 Diagrams, 1 Chart, 2 Graphs. |
| Subjects: | Genomics, Archaebacteria, Bacteria, Genomes, Phylogeny, Biological evolution, Microorganisms, Fungus-bacterium relationships, Microbiology |
| Abstract: | Sequencing of bacterial and archaeal genomes has revolutionized our understanding of the many roles played by microorganisms. There are now nearly 1,000 completed bacterial and archaeal genomes available, most of which were chosen for sequencing on the basis of their physiology. As a result, the perspective provided by the currently available genomes is limited by a highly biased phylogenetic distribution. To explore the value added by choosing microbial genomes for sequencing on the basis of their evolutionary relationships, we have sequenced and analysed the genomes of 56 culturable species of Bacteria and Archaea selected to maximize phylogenetic coverage. Analysis of these genomes demonstrated pronounced benefits (compared to an equivalent set of genomes randomly selected from the existing database) in diverse areas including the reconstruction of phylogenetic history, the discovery of new protein families and biological properties, and the prediction of functions for known genes from other organisms. Our results strongly support the need for systematic ‘phylogenomic’ efforts to compile a phylogeny-driven ‘Genomic Encyclopedia of Bacteria and Archaea’ in order to derive maximum knowledge from existing microbial genome data as well as from genome sequences to come. [ABSTRACT FROM AUTHOR] |
| Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 47127148 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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There are now nearly 1,000 completed bacterial and archaeal genomes available, most of which were chosen for sequencing on the basis of their physiology. As a result, the perspective provided by the currently available genomes is limited by a highly biased phylogenetic distribution. To explore the value added by choosing microbial genomes for sequencing on the basis of their evolutionary relationships, we have sequenced and analysed the genomes of 56 culturable species of Bacteria and Archaea selected to maximize phylogenetic coverage. Analysis of these genomes demonstrated pronounced benefits (compared to an equivalent set of genomes randomly selected from the existing database) in diverse areas including the reconstruction of phylogenetic history, the discovery of new protein families and biological properties, and the prediction of functions for known genes from other organisms. Our results strongly support the need for systematic ‘phylogenomic’ efforts to compile a phylogeny-driven ‘Genomic Encyclopedia of Bacteria and Archaea’ in order to derive maximum knowledge from existing microbial genome data as well as from genome sequences to come. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=47127148 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/nature08656 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 1056 Subjects: – SubjectFull: Genomics Type: general – SubjectFull: Archaebacteria Type: general – SubjectFull: Bacteria Type: general – SubjectFull: Genomes Type: general – SubjectFull: Phylogeny Type: general – SubjectFull: Biological evolution Type: general – SubjectFull: Microorganisms Type: general – SubjectFull: Fungus-bacterium relationships Type: general – SubjectFull: Microbiology Type: general Titles: – TitleFull: A phylogeny-driven genomic encyclopaedia of Bacteria and Archaea. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Dongying Wu – PersonEntity: Name: NameFull: Hugenholtz, Philip – PersonEntity: Name: NameFull: Mavromatis, Konstantinos – PersonEntity: Name: NameFull: Pukall, Rüdiger – PersonEntity: Name: NameFull: Dalin, Eileen – PersonEntity: Name: NameFull: Ivanova, Natalia N. – PersonEntity: Name: NameFull: Kunin, Victor – PersonEntity: Name: NameFull: Goodwin, Lynne – PersonEntity: Name: NameFull: Wu, Martin – PersonEntity: Name: NameFull: Tindall, Brian J. – PersonEntity: Name: NameFull: Hooper, Sean D. – PersonEntity: Name: NameFull: Pati, Amrita – PersonEntity: Name: NameFull: Lykidis, Athanasios – PersonEntity: Name: NameFull: Spring, Stefan – PersonEntity: Name: NameFull: Anderson, Iain J. – PersonEntity: Name: NameFull: D'haeseleer, Patrik – PersonEntity: Name: NameFull: Zemla, Adam – PersonEntity: Name: NameFull: Singer, Mitchell – PersonEntity: Name: NameFull: Lapidus, Alla – PersonEntity: Name: NameFull: Nolan, Matt IsPartOfRelationships: – BibEntity: Dates: – D: 24 M: 12 Text: 12/24/2009 Type: published Y: 2009 Identifiers: – Type: issn-print Value: 00280836 Numbering: – Type: volume Value: 462 – Type: issue Value: 7276 Titles: – TitleFull: Nature Type: main |
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