Pontocerebellar volume deficits and ataxia in alcoholic men and women: no evidence for “telescoping”.
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| Title: | Pontocerebellar volume deficits and ataxia in alcoholic men and women: no evidence for “telescoping”. |
|---|---|
| Authors: | Sullivan, Edith V., Rohlfing, Torsten, Pfefferbaum, Adolf |
| Source: | Psychopharmacology. Feb2010, Vol. 208 Issue 2, p279-290. 12p. 1 Black and White Photograph, 3 Charts, 4 Graphs. |
| Subjects: | Alcoholism, Brain diseases, Alcohol drinking, Ataxia, Movement disorders |
| Abstract: | Brain volume shrinkage is common in treatment-seeking patients with alcohol use disorders. Whether women are more vulnerable to brain dysmorphology than men despite lower alcohol consumption levels or shorter dependency (“telescoping effect”) remains controversial and has not been considered with respect to infratentorial structures or their potential contribution to ataxia. The 200 participants included 64 men and 31 women with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition alcohol dependence and 105 controls. An infratentorial region (pons, cerebellar hemispheres, vermis (anterior, posterior, and inferior sectors), fissures, cisterns, fourth ventricle) was quantified with atlas-based parcellation. To enable comparison of men and women, regional tissue volumes were expressed as ratios of tissue in the volume. Participants also completed quantitative ataxia testing. Total infratentorial and vermian tissue ratios were significantly smaller in alcoholics than controls; alcoholic women did not show disproportionately greater volume deficits than alcoholic men. A re-analysis including alcoholic men and women matched in alcohol consumption, onset age, abstinence duration, and age revealed again that alcoholic women did not have disproportionately greater regional vermian volume deficits than alcoholic men. Alcoholic men and women were impaired in all measures of ataxia, which correlated with low infratentorial tissue ratios in men. Alcoholic men showed deficits of pontocerebellar volume ratios, yet alcoholic women did not display signs of “telescoping”. Further, alcoholic men and women both showed signs of ataxia of gait and balance, related to affected pontocerebellar systems in the men but not the women, suggesting the need to consider other neural substrates for ataxia in women. [ABSTRACT FROM AUTHOR] |
| Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 47145269 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Pontocerebellar volume deficits and ataxia in alcoholic men and women: no evidence for “telescoping”. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Sullivan%2C+Edith+V%2E%22">Sullivan, Edith V.</searchLink><br /><searchLink fieldCode="AR" term="%22Rohlfing%2C+Torsten%22">Rohlfing, Torsten</searchLink><br /><searchLink fieldCode="AR" term="%22Pfefferbaum%2C+Adolf%22">Pfefferbaum, Adolf</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Psychopharmacology%22">Psychopharmacology</searchLink>. Feb2010, Vol. 208 Issue 2, p279-290. 12p. 1 Black and White Photograph, 3 Charts, 4 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Alcoholism%22">Alcoholism</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+diseases%22">Brain diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Alcohol+drinking%22">Alcohol drinking</searchLink><br /><searchLink fieldCode="DE" term="%22Ataxia%22">Ataxia</searchLink><br /><searchLink fieldCode="DE" term="%22Movement+disorders%22">Movement disorders</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Brain volume shrinkage is common in treatment-seeking patients with alcohol use disorders. Whether women are more vulnerable to brain dysmorphology than men despite lower alcohol consumption levels or shorter dependency (“telescoping effect”) remains controversial and has not been considered with respect to infratentorial structures or their potential contribution to ataxia. The 200 participants included 64 men and 31 women with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition alcohol dependence and 105 controls. An infratentorial region (pons, cerebellar hemispheres, vermis (anterior, posterior, and inferior sectors), fissures, cisterns, fourth ventricle) was quantified with atlas-based parcellation. To enable comparison of men and women, regional tissue volumes were expressed as ratios of tissue in the volume. Participants also completed quantitative ataxia testing. Total infratentorial and vermian tissue ratios were significantly smaller in alcoholics than controls; alcoholic women did not show disproportionately greater volume deficits than alcoholic men. A re-analysis including alcoholic men and women matched in alcohol consumption, onset age, abstinence duration, and age revealed again that alcoholic women did not have disproportionately greater regional vermian volume deficits than alcoholic men. Alcoholic men and women were impaired in all measures of ataxia, which correlated with low infratentorial tissue ratios in men. Alcoholic men showed deficits of pontocerebellar volume ratios, yet alcoholic women did not display signs of “telescoping”. Further, alcoholic men and women both showed signs of ataxia of gait and balance, related to affected pontocerebellar systems in the men but not the women, suggesting the need to consider other neural substrates for ataxia in women. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Psychopharmacology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00213-009-1729-7 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 279 Subjects: – SubjectFull: Alcoholism Type: general – SubjectFull: Brain diseases Type: general – SubjectFull: Alcohol drinking Type: general – SubjectFull: Ataxia Type: general – SubjectFull: Movement disorders Type: general Titles: – TitleFull: Pontocerebellar volume deficits and ataxia in alcoholic men and women: no evidence for “telescoping”. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sullivan, Edith V. – PersonEntity: Name: NameFull: Rohlfing, Torsten – PersonEntity: Name: NameFull: Pfefferbaum, Adolf IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 02 Text: Feb2010 Type: published Y: 2010 Identifiers: – Type: issn-print Value: 00333158 Numbering: – Type: volume Value: 208 – Type: issue Value: 2 Titles: – TitleFull: Psychopharmacology Type: main |
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