Long-Term Treatment of Severe Familial Hypercholesterolemia in Children: Effect of Sitosterol and Bezafibrate.
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| Title: | Long-Term Treatment of Severe Familial Hypercholesterolemia in Children: Effect of Sitosterol and Bezafibrate. |
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| Authors: | Becker, M., Staab, D., Von Bergmann, K. |
| Source: | Pediatrics. Jan92, Vol. 89 Issue 1, p138. 5p. |
| Subjects: | Hypercholesteremia in children, Diet therapy for children, Diet therapy |
| Abstract: | Abstract. Seven prepubertal children (age range 5.3 to 10.8 years) with severe heterozygous familial hypercholesterolemia (serum cholesterol concentration 416 +/85 mg/dL and low-density lipoprotein [LDL] cholesterol concentration 360 +/- 90 mg/dL) were first treated by dietary intervention, second by sitosterol (3 x 2 g/d), and third by bezafibrate (2 x 200 mg/d). Each treatment period lasted 3 months. Subsequently, a treatment combining half the dose of sitosterol and bezafibrate was administered for the following 24 months. Diet alone reduced total and LDL cholesterol values by 4.5% (not significant) and 6.6% (P < .05), respectively. Sitosterol lowered total and LDL cholesterol values by 17% (P < .05) when compared with diet alone. Compared with sitosterol, bezafibrate produced a more pronounced effect on total and LDL cholesterol values (-18% and -28%, P < .05), and high-density lipoprotein cholesterol concentration increased significantly from 48 mg/dL to 55 mg/dL. Combined treatment with half the dose each of sitosterol and bezafibrate was as effective as the higher dose of bezafibrate, and reduction averaged almost 40% and 50% for total and LDL cholesterol values; this lipid-lowering effect persisted for the next 24 months. Laboratory safety parameters and physical examination revealed no obvious side effects. This study indicates that the combination of sitosterol (3 x 1 g/d) plus bezafibrate (1 x 200 mg/d) is an alternate, acceptable, safe, and effective therapeutic approach for treatment of severe hypercholesterolemia in children with high-risk familial hypercholesterolemia. Pediatrics 1992;89:138-142; familial hypercholesterolemia, cholesterol, sitosterol, bezafibrate, children. [ABSTRACT FROM AUTHOR] |
| Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 4747700 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Long-Term Treatment of Severe Familial Hypercholesterolemia in Children: Effect of Sitosterol and Bezafibrate. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Becker%2C+M%2E%22">Becker, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Staab%2C+D%2E%22">Staab, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Von+Bergmann%2C+K%2E%22">Von Bergmann, K.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. Jan92, Vol. 89 Issue 1, p138. 5p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Hypercholesteremia+in+children%22">Hypercholesteremia in children</searchLink><br /><searchLink fieldCode="DE" term="%22Diet+therapy+for+children%22">Diet therapy for children</searchLink><br /><searchLink fieldCode="DE" term="%22Diet+therapy%22">Diet therapy</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract. Seven prepubertal children (age range 5.3 to 10.8 years) with severe heterozygous familial hypercholesterolemia (serum cholesterol concentration 416 +/85 mg/dL and low-density lipoprotein [LDL] cholesterol concentration 360 +/- 90 mg/dL) were first treated by dietary intervention, second by sitosterol (3 x 2 g/d), and third by bezafibrate (2 x 200 mg/d). Each treatment period lasted 3 months. Subsequently, a treatment combining half the dose of sitosterol and bezafibrate was administered for the following 24 months. Diet alone reduced total and LDL cholesterol values by 4.5% (not significant) and 6.6% (P < .05), respectively. Sitosterol lowered total and LDL cholesterol values by 17% (P < .05) when compared with diet alone. Compared with sitosterol, bezafibrate produced a more pronounced effect on total and LDL cholesterol values (-18% and -28%, P < .05), and high-density lipoprotein cholesterol concentration increased significantly from 48 mg/dL to 55 mg/dL. Combined treatment with half the dose each of sitosterol and bezafibrate was as effective as the higher dose of bezafibrate, and reduction averaged almost 40% and 50% for total and LDL cholesterol values; this lipid-lowering effect persisted for the next 24 months. Laboratory safety parameters and physical examination revealed no obvious side effects. This study indicates that the combination of sitosterol (3 x 1 g/d) plus bezafibrate (1 x 200 mg/d) is an alternate, acceptable, safe, and effective therapeutic approach for treatment of severe hypercholesterolemia in children with high-risk familial hypercholesterolemia. Pediatrics 1992;89:138-142; familial hypercholesterolemia, cholesterol, sitosterol, bezafibrate, children. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=4747700 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1542/peds.89.1.138 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 138 Subjects: – SubjectFull: Hypercholesteremia in children Type: general – SubjectFull: Diet therapy for children Type: general – SubjectFull: Diet therapy Type: general Titles: – TitleFull: Long-Term Treatment of Severe Familial Hypercholesterolemia in Children: Effect of Sitosterol and Bezafibrate. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Becker, M. – PersonEntity: Name: NameFull: Staab, D. – PersonEntity: Name: NameFull: Von Bergmann, K. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 01 Text: Jan92 Type: published Y: 1992 Identifiers: – Type: issn-print Value: 00314005 Numbering: – Type: volume Value: 89 – Type: issue Value: 1 Titles: – TitleFull: Pediatrics Type: main |
| ResultId | 1 |
