View in EDS

'Reactive Gliosis' in the Medulla Oblongata of Victims of the Sudden Infant Death Syndrome.

Saved in:
Bibliographic Details
Title: 'Reactive Gliosis' in the Medulla Oblongata of Victims of the Sudden Infant Death Syndrome.
Authors: Kinney, Hannah C., Burger, Peter C., Harrell Jr., Frank E., Hudson Jr., R. Page
Source: Pediatrics. Aug83, Vol. 72 Issue 2, p181. 7p.
Subjects: Medulla oblongata abnormalities, Sudden infant death syndrome, Infant death
Abstract: Abstract. A current hypothesis that the sudden infant death syndrome (SIDS) is a sleep apnea syndrome precipitated by defective control of involuntary respiration prompted the present study in which "reactive gliosis" in sections of the medulla oblongata of 45 SIDS victims was quantitated and compared with that in 20 control infants. Six anatomic regions were studied; five are related and one is unrelated to neural control of involuntary respiration. Increased numbers of "reactive" astrocytes were found in the SIDS group when the counts for all regions were combined (P = .04). Counts were also significantly higher in the SIDS victims for each of three regions alone: (1) the hilum of the inferior olivary nucleus (P = .01); (2) a lateral region (P = .02); and (3) the nucleus of the tractus solitarius (P = .03). The region with the greatest statistical difference, the inferior olivary hilum, has no recognized role in the control of involuntary respiration. There were no consistent associations between reactive astrocyte counts and specific clinical, socioeconomic, and pathologic variables. Characterization of the SIDS group whose counts exceeded that of the highest control infant also did not uncover distinguishing features. This study reinforces previous observations that, at least statistically, an abnormality of the brainstem occurs in a group of SIDS victims in contrast to a group of control infants, but also discloses considerable overlap in the numbers of such cells between these two groups. [ABSTRACT FROM AUTHOR]
Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 4749019
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: 'Reactive Gliosis' in the Medulla Oblongata of Victims of the Sudden Infant Death Syndrome.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Kinney%2C+Hannah+C%2E%22">Kinney, Hannah C.</searchLink><br /><searchLink fieldCode="AR" term="%22Burger%2C+Peter+C%2E%22">Burger, Peter C.</searchLink><br /><searchLink fieldCode="AR" term="%22Harrell+Jr%2E%2C+Frank+E%2E%22">Harrell Jr., Frank E.</searchLink><br /><searchLink fieldCode="AR" term="%22Hudson+Jr%2E%2C+R%2E+Page%22">Hudson Jr., R. Page</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. Aug83, Vol. 72 Issue 2, p181. 7p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Medulla+oblongata+abnormalities%22">Medulla oblongata abnormalities</searchLink><br /><searchLink fieldCode="DE" term="%22Sudden+infant+death+syndrome%22">Sudden infant death syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Infant+death%22">Infant death</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Abstract. A current hypothesis that the sudden infant death syndrome (SIDS) is a sleep apnea syndrome precipitated by defective control of involuntary respiration prompted the present study in which "reactive gliosis" in sections of the medulla oblongata of 45 SIDS victims was quantitated and compared with that in 20 control infants. Six anatomic regions were studied; five are related and one is unrelated to neural control of involuntary respiration. Increased numbers of "reactive" astrocytes were found in the SIDS group when the counts for all regions were combined (P = .04). Counts were also significantly higher in the SIDS victims for each of three regions alone: (1) the hilum of the inferior olivary nucleus (P = .01); (2) a lateral region (P = .02); and (3) the nucleus of the tractus solitarius (P = .03). The region with the greatest statistical difference, the inferior olivary hilum, has no recognized role in the control of involuntary respiration. There were no consistent associations between reactive astrocyte counts and specific clinical, socioeconomic, and pathologic variables. Characterization of the SIDS group whose counts exceeded that of the highest control infant also did not uncover distinguishing features. This study reinforces previous observations that, at least statistically, an abnormality of the brainstem occurs in a group of SIDS victims in contrast to a group of control infants, but also discloses considerable overlap in the numbers of such cells between these two groups. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=4749019
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1542/peds.72.2.181
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 181
    Subjects:
      – SubjectFull: Medulla oblongata abnormalities
        Type: general
      – SubjectFull: Sudden infant death syndrome
        Type: general
      – SubjectFull: Infant death
        Type: general
    Titles:
      – TitleFull: 'Reactive Gliosis' in the Medulla Oblongata of Victims of the Sudden Infant Death Syndrome.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Kinney, Hannah C.
      – PersonEntity:
          Name:
            NameFull: Burger, Peter C.
      – PersonEntity:
          Name:
            NameFull: Harrell Jr., Frank E.
      – PersonEntity:
          Name:
            NameFull: Hudson Jr., R. Page
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 08
              Text: Aug83
              Type: published
              Y: 1983
          Identifiers:
            – Type: issn-print
              Value: 00314005
          Numbering:
            – Type: volume
              Value: 72
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Pediatrics
              Type: main
ResultId 1