Neonatal Hypothyroidism Detected by the Northwest Regional Screening Program.
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| Title: | Neonatal Hypothyroidism Detected by the Northwest Regional Screening Program. |
|---|---|
| Authors: | LaFranchi, Stephen H., Murphey, William H., Foley Jr., Thomas P., Larsen, P. Reed, Buist, Nell R.M. |
| Source: | Pediatrics. Feb79, Vol. 63 Issue 2, p180. 12p. |
| Subjects: | Congenital hypothyroidism, Medical screening, Thyroxine |
| Abstract: | ABSTRACT. The Northwest Regional Screening Program to detect congenital hypothyroidism in infants born in Oregon, Montana, Alaska, and Idaho (combined birthrate of 69,000/ yr) was added to our ongoing screening program in 1975. The program utilizes dried blood filter paper specimens collected routinely in the first few days of life in all four states and again at about 6 weeks of age in Oregon only. The screening tests consist of an initial thyroxine (T[sub 4]) measurement; a thyroid-stimulating hormone (TSH) determination is performed on those specimens with T[sub 4] concentrations in the lowest 3% group. Serum samples obtained by venipuncture are requested for confirmation of the diagnosis. In the first two years of the program, 25 infants with primary hypothyroidism were detected among 110,667 infants screened, a frequency of 1:4,430. Fourteen cases of thyroxine-binding globulin deficiency were also detected, a frequency of 1:7,900. Using the T[sub 4] followed by TSH testing approach, the frequency of requests for repeat specimens was 0.4% in Oregon and 0.05% in the other states. The cost per specimen was $1.96. The majority of infants lacked clinical signs or symptoms of hypothyroidism; only one infant was clinically suspected of having hypothyroidism prior to detection. The most common neonatal symptoms were constipation, lethargy, and prolonged jaundice, while the most common physical signs were hypotonia, umbilical hernia, and large fontanels. Thyroid scans showed the most common etiology to be thyroid aplasia, followed by an ectopic gland, hypoplasia, and goiter. Serum T[sub 4] concentrations were lowest in those infants with aplasia, intermediate in infants with an ectopic gland or hypoplasia, and normal in the infant with the goiter. Neonatal hypothyroidism varies in degree and has several different causes; the capacity to secrete thyroid hormone, the duration before hypothyroidism becomes clinically manifest, and possibly the eventual prognosis for... [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 4755542 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Neonatal Hypothyroidism Detected by the Northwest Regional Screening Program. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22LaFranchi%2C+Stephen+H%2E%22">LaFranchi, Stephen H.</searchLink><br /><searchLink fieldCode="AR" term="%22Murphey%2C+William+H%2E%22">Murphey, William H.</searchLink><br /><searchLink fieldCode="AR" term="%22Foley+Jr%2E%2C+Thomas+P%2E%22">Foley Jr., Thomas P.</searchLink><br /><searchLink fieldCode="AR" term="%22Larsen%2C+P%2E+Reed%22">Larsen, P. Reed</searchLink><br /><searchLink fieldCode="AR" term="%22Buist%2C+Nell+R%2EM%2E%22">Buist, Nell R.M.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Pediatrics%22">Pediatrics</searchLink>. Feb79, Vol. 63 Issue 2, p180. 12p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Congenital+hypothyroidism%22">Congenital hypothyroidism</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+screening%22">Medical screening</searchLink><br /><searchLink fieldCode="DE" term="%22Thyroxine%22">Thyroxine</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: ABSTRACT. The Northwest Regional Screening Program to detect congenital hypothyroidism in infants born in Oregon, Montana, Alaska, and Idaho (combined birthrate of 69,000/ yr) was added to our ongoing screening program in 1975. The program utilizes dried blood filter paper specimens collected routinely in the first few days of life in all four states and again at about 6 weeks of age in Oregon only. The screening tests consist of an initial thyroxine (T[sub 4]) measurement; a thyroid-stimulating hormone (TSH) determination is performed on those specimens with T[sub 4] concentrations in the lowest 3% group. Serum samples obtained by venipuncture are requested for confirmation of the diagnosis. In the first two years of the program, 25 infants with primary hypothyroidism were detected among 110,667 infants screened, a frequency of 1:4,430. Fourteen cases of thyroxine-binding globulin deficiency were also detected, a frequency of 1:7,900. Using the T[sub 4] followed by TSH testing approach, the frequency of requests for repeat specimens was 0.4% in Oregon and 0.05% in the other states. The cost per specimen was $1.96. The majority of infants lacked clinical signs or symptoms of hypothyroidism; only one infant was clinically suspected of having hypothyroidism prior to detection. The most common neonatal symptoms were constipation, lethargy, and prolonged jaundice, while the most common physical signs were hypotonia, umbilical hernia, and large fontanels. Thyroid scans showed the most common etiology to be thyroid aplasia, followed by an ectopic gland, hypoplasia, and goiter. Serum T[sub 4] concentrations were lowest in those infants with aplasia, intermediate in infants with an ectopic gland or hypoplasia, and normal in the infant with the goiter. Neonatal hypothyroidism varies in degree and has several different causes; the capacity to secrete thyroid hormone, the duration before hypothyroidism becomes clinically manifest, and possibly the eventual prognosis for... [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Pediatrics is the property of American Academy of Pediatrics and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1542/peds.63.2.180 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 180 Subjects: – SubjectFull: Congenital hypothyroidism Type: general – SubjectFull: Medical screening Type: general – SubjectFull: Thyroxine Type: general Titles: – TitleFull: Neonatal Hypothyroidism Detected by the Northwest Regional Screening Program. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: LaFranchi, Stephen H. – PersonEntity: Name: NameFull: Murphey, William H. – PersonEntity: Name: NameFull: Foley Jr., Thomas P. – PersonEntity: Name: NameFull: Larsen, P. Reed – PersonEntity: Name: NameFull: Buist, Nell R.M. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb79 Type: published Y: 1979 Identifiers: – Type: issn-print Value: 00314005 Numbering: – Type: volume Value: 63 – Type: issue Value: 2 Titles: – TitleFull: Pediatrics Type: main |
| ResultId | 1 |
