An ordinary mixed meal transiently impairs endothelium-dependent vasodilation in healthy subjects.
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| Title: | An ordinary mixed meal transiently impairs endothelium-dependent vasodilation in healthy subjects. |
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| Authors: | Sarabi, M., Fugmann, A., Karlström, B., Berne, C., Lithell, H., Lind, L. |
| Source: | Acta Physiologica Scandinavica. Jun2001, Vol. 172 Issue 2, p107-113. 7p. 4 Graphs. |
| Subjects: | Ingestion, Endothelium physiology, Vasodilation, Fatty acids, Physiology |
| Abstract: | This study was designed to evaluate the effects of an ordinary mixed meal on endothelium-dependent vasodilation. Ten young healthy volunteers were given a mixed meal (minced meat sauce with rice, 900 kcal, 34% of the energy content was fat). In the fasting state, at 60 and 120 min after the start of the meal, endothelium-dependent vasodilation and endothelium-independent vasodilation were evaluated by local infusion of metacholine (4 μg min–1) and sodium nitroprusside (10 μg min–1) in the brachial artery. Blood flow in the forearm was measured using venous occlusion plethysmography. Endothelium-dependent vasodilation decreased from 15.4 ± 3.3 (mean ± SD) at fasting to 13.7 ± 3.5 mL min–1 (100 mL tissue)–1 (P < 0.01) 60 min after feeding, but had returned to the fasting level at 120 min. At 60 min, but not in the fasting state, the serum level of free fatty acids was inversely related to endothelium-dependent vasodilation (r=–0.74, P < 0.05), although no significant net changes in FFA levels were seen. Endothelium-independent vasodilation was not affected by the mixed meal. No similar attenuations in endothelium-dependent vasodilation were seen during control meals. In conclusion, an ordinary mixed meal transiently attenuated endothelium-dependent vasodilation. Free fatty acids may be involved in this effect on endothelial function. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Physiologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 4812022 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: An ordinary mixed meal transiently impairs endothelium-dependent vasodilation in healthy subjects. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Sarabi%2C+M%2E%22">Sarabi, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Fugmann%2C+A%2E%22">Fugmann, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Karlström%2C+B%2E%22">Karlström, B.</searchLink><br /><searchLink fieldCode="AR" term="%22Berne%2C+C%2E%22">Berne, C.</searchLink><br /><searchLink fieldCode="AR" term="%22Lithell%2C+H%2E%22">Lithell, H.</searchLink><br /><searchLink fieldCode="AR" term="%22Lind%2C+L%2E%22">Lind, L.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Physiologica+Scandinavica%22">Acta Physiologica Scandinavica</searchLink>. Jun2001, Vol. 172 Issue 2, p107-113. 7p. 4 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Ingestion%22">Ingestion</searchLink><br /><searchLink fieldCode="DE" term="%22Endothelium+physiology%22">Endothelium physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Vasodilation%22">Vasodilation</searchLink><br /><searchLink fieldCode="DE" term="%22Fatty+acids%22">Fatty acids</searchLink><br /><searchLink fieldCode="DE" term="%22Physiology%22">Physiology</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: This study was designed to evaluate the effects of an ordinary mixed meal on endothelium-dependent vasodilation. Ten young healthy volunteers were given a mixed meal (minced meat sauce with rice, 900 kcal, 34% of the energy content was fat). In the fasting state, at 60 and 120 min after the start of the meal, endothelium-dependent vasodilation and endothelium-independent vasodilation were evaluated by local infusion of metacholine (4 μg min–1) and sodium nitroprusside (10 μg min–1) in the brachial artery. Blood flow in the forearm was measured using venous occlusion plethysmography. Endothelium-dependent vasodilation decreased from 15.4 ± 3.3 (mean ± SD) at fasting to 13.7 ± 3.5 mL min–1 (100 mL tissue)–1 (P < 0.01) 60 min after feeding, but had returned to the fasting level at 120 min. At 60 min, but not in the fasting state, the serum level of free fatty acids was inversely related to endothelium-dependent vasodilation (r=–0.74, P < 0.05), although no significant net changes in FFA levels were seen. Endothelium-independent vasodilation was not affected by the mixed meal. No similar attenuations in endothelium-dependent vasodilation were seen during control meals. In conclusion, an ordinary mixed meal transiently attenuated endothelium-dependent vasodilation. Free fatty acids may be involved in this effect on endothelial function. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Physiologica Scandinavica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=4812022 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1046/j.1365-201X.2001.00845.x Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 107 Subjects: – SubjectFull: Ingestion Type: general – SubjectFull: Endothelium physiology Type: general – SubjectFull: Vasodilation Type: general – SubjectFull: Fatty acids Type: general – SubjectFull: Physiology Type: general Titles: – TitleFull: An ordinary mixed meal transiently impairs endothelium-dependent vasodilation in healthy subjects. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sarabi, M. – PersonEntity: Name: NameFull: Fugmann, A. – PersonEntity: Name: NameFull: Karlström, B. – PersonEntity: Name: NameFull: Berne, C. – PersonEntity: Name: NameFull: Lithell, H. – PersonEntity: Name: NameFull: Lind, L. IsPartOfRelationships: – BibEntity: Dates: – D: 08 M: 06 Text: Jun2001 Type: published Y: 2001 Identifiers: – Type: issn-print Value: 00016772 Numbering: – Type: volume Value: 172 – Type: issue Value: 2 Titles: – TitleFull: Acta Physiologica Scandinavica Type: main |
| ResultId | 1 |
