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Developmental changes in presynaptic Ca2+ clearance kinetics and synaptic plasticity in mouse Schaffer collateral terminals.

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Title: Developmental changes in presynaptic Ca2+ clearance kinetics and synaptic plasticity in mouse Schaffer collateral terminals.
Authors: Scullin, Chessa S. (AUTHOR), Wilson, Michael C. (AUTHOR), Partridge, L. Donald (AUTHOR)
Source: European Journal of Neuroscience. Mar2010, Vol. 31 Issue 5, p817-826. 10p. 7 Graphs.
Subjects: Presynaptic receptors, Neuroplasticity, Laboratory rats, Neurotransmitters, Neurons
Abstract: Presynaptic Ca2+ influx pathways, cytoplasmic Ca2+ buffering proteins and Ca2+ extrusion processes undergo considerable change during the first postnatal month in rodent neurons. These changes may be critical in establishing short-term plasticity at maturing presynaptic terminals where neurotransmitter release is directly dependent on the dynamics of cytoplasmic residual Ca2+ ([Ca2+]res). In particular, the robust paired-pulse facilitation characteristic of adult neurons is almost entirely lacking in newborns. To examine developmental changes in processes controlling [Ca2+]res, we measured the timecourse of [Ca2+]res decay in presynaptic terminals of Schaffer collateral to CA1 synapses in acute hippocampal slices following single and paired orthodromic stimuli in the stratum radiatum. Developmental changes were observed in both the rise time and slow exponential decay components of the response to single stimuli such that this decay was larger and faster in the adult. Furthermore, we observed a greater caffeine-sensitive basal Ca2+ store, which was differentially affected when active uptake into the endoplasmic reticulum was blocked, in the presynaptic fields of the Schaffer collateral to CA1 terminals of P6 and younger mice when compared to adults. These transitions in [Ca2+]res dynamics occurred gradually over the first weeks of postnatal life and correlated with changes in short-term plasticity. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Developmental changes in presynaptic Ca<superscript>2+</superscript> clearance kinetics and synaptic plasticity in mouse Schaffer collateral terminals.
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  Data: <searchLink fieldCode="AR" term="%22Scullin%2C+Chessa+S%2E%22">Scullin, Chessa S.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wilson%2C+Michael+C%2E%22">Wilson, Michael C.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Partridge%2C+L%2E+Donald%22">Partridge, L. Donald</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Mar2010, Vol. 31 Issue 5, p817-826. 10p. 7 Graphs.
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  Data: <searchLink fieldCode="DE" term="%22Presynaptic+receptors%22">Presynaptic receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroplasticity%22">Neuroplasticity</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+rats%22">Laboratory rats</searchLink><br /><searchLink fieldCode="DE" term="%22Neurotransmitters%22">Neurotransmitters</searchLink><br /><searchLink fieldCode="DE" term="%22Neurons%22">Neurons</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Presynaptic Ca2+ influx pathways, cytoplasmic Ca2+ buffering proteins and Ca2+ extrusion processes undergo considerable change during the first postnatal month in rodent neurons. These changes may be critical in establishing short-term plasticity at maturing presynaptic terminals where neurotransmitter release is directly dependent on the dynamics of cytoplasmic residual Ca2+ ([Ca2+]res). In particular, the robust paired-pulse facilitation characteristic of adult neurons is almost entirely lacking in newborns. To examine developmental changes in processes controlling [Ca2+]res, we measured the timecourse of [Ca2+]res decay in presynaptic terminals of Schaffer collateral to CA1 synapses in acute hippocampal slices following single and paired orthodromic stimuli in the stratum radiatum. Developmental changes were observed in both the rise time and slow exponential decay components of the response to single stimuli such that this decay was larger and faster in the adult. Furthermore, we observed a greater caffeine-sensitive basal Ca2+ store, which was differentially affected when active uptake into the endoplasmic reticulum was blocked, in the presynaptic fields of the Schaffer collateral to CA1 terminals of P6 and younger mice when compared to adults. These transitions in [Ca2+]res dynamics occurred gradually over the first weeks of postnatal life and correlated with changes in short-term plasticity. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1111/j.1460-9568.2010.07137.x
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      – Code: eng
        Text: English
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      – SubjectFull: Presynaptic receptors
        Type: general
      – SubjectFull: Neuroplasticity
        Type: general
      – SubjectFull: Laboratory rats
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      – SubjectFull: Neurotransmitters
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      – SubjectFull: Neurons
        Type: general
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      – TitleFull: Developmental changes in presynaptic Ca2+ clearance kinetics and synaptic plasticity in mouse Schaffer collateral terminals.
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            NameFull: Wilson, Michael C.
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            NameFull: Partridge, L. Donald
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              M: 03
              Text: Mar2010
              Type: published
              Y: 2010
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            – TitleFull: European Journal of Neuroscience
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