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Expression of p53, p16INK4A, pRb, p21WAF1/CIP1, p27KIP1, cyclin D1, Ki-67 and HPV DNA in sinonasal endophytic Schneiderian (inverted) papilloma.

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Title: Expression of p53, p16INK4A, pRb, p21WAF1/CIP1, p27KIP1, cyclin D1, Ki-67 and HPV DNA in sinonasal endophytic Schneiderian (inverted) papilloma.
Authors: Altavilla, Giuseppe (AUTHOR), Staffieri, Alberto (AUTHOR), Busatto, Graziella (AUTHOR), Canesso, Alessandra (AUTHOR), Giacomelli, Luciano (AUTHOR), Marioni, Gino (AUTHOR)
Source: Acta Oto-Laryngologica. Nov2009, Vol. 129 Issue 11, p1242-1249. 8p. 2 Color Photographs, 1 Black and White Photograph, 2 Charts.
Subjects: Papillomaviruses, Nasal tumors, Immunohistochemistry, Polymerase chain reaction, Otolaryngology
Abstract: Conclusions. Human papilloma virus (HPV) was associated with sinonasal inverted papilloma (SIP) in 14/20 (70%) patients with a prevalence of HPV 6/11; alterations of the cell cycle proteins were statistically significant. Objectives. We investigated SIPs relationships between HPV infection and aberrant expression of cell cycle proteins. Materials and methods. Twenty SIPs were evaluated for p53, p16INK4a, pRb, p21WAF1, p27Kip1, cyclin D1 and Ki-67 expression by immunohistochemistry. HPV was investigated by polymerase chain reaction (PCR). Results. HPV DNA was detected in 14/20 patients with inverted papillomas (IPs) (70%). The majority of tumours showed strong p16, p21, p27, pRb and cyclin D1 staining and little or no p53 expression. Tumours harbouring dysplasia were significantly more likely to be p53-positive and exhibit up-regulated p21 and p27, and showed altered intensity and distribution of reactive cells into and through the epithelium. Dysplastic epithelium was strongly reactive for p16 and the MIB 1 labelling index was almost 20%. These findings were associated with expression of p53 in the same zones. Comparing the p53 reactivity with the presence of HPV DNA, SIPs were stratified as follows: HPV + p53−, 12 (63.15%); HPV + p53+, 2 (10.52%); HPV − p53+, 3 (15.78%) and HPV − p53−, 2 (10.52%). Statistical analysis showed that HPV presence correlated with p53-positive immunostaining ( p=0.045). [ABSTRACT FROM AUTHOR]
Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Expression of p53, p16<superscript>INK4A</superscript>, pRb, p21<superscript>WAF1/CIP1</superscript>, p27<superscript>KIP1</superscript>, cyclin D1, Ki-67 and HPV DNA in sinonasal endophytic Schneiderian (inverted) papilloma.
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  Data: <searchLink fieldCode="AR" term="%22Altavilla%2C+Giuseppe%22">Altavilla, Giuseppe</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Staffieri%2C+Alberto%22">Staffieri, Alberto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Busatto%2C+Graziella%22">Busatto, Graziella</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Canesso%2C+Alessandra%22">Canesso, Alessandra</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Giacomelli%2C+Luciano%22">Giacomelli, Luciano</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Marioni%2C+Gino%22">Marioni, Gino</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica%22">Acta Oto-Laryngologica</searchLink>. Nov2009, Vol. 129 Issue 11, p1242-1249. 8p. 2 Color Photographs, 1 Black and White Photograph, 2 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Papillomaviruses%22">Papillomaviruses</searchLink><br /><searchLink fieldCode="DE" term="%22Nasal+tumors%22">Nasal tumors</searchLink><br /><searchLink fieldCode="DE" term="%22Immunohistochemistry%22">Immunohistochemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Polymerase+chain+reaction%22">Polymerase chain reaction</searchLink><br /><searchLink fieldCode="DE" term="%22Otolaryngology%22">Otolaryngology</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Conclusions. Human papilloma virus (HPV) was associated with sinonasal inverted papilloma (SIP) in 14/20 (70%) patients with a prevalence of HPV 6/11; alterations of the cell cycle proteins were statistically significant. Objectives. We investigated SIPs relationships between HPV infection and aberrant expression of cell cycle proteins. Materials and methods. Twenty SIPs were evaluated for p53, p16INK4a, pRb, p21WAF1, p27Kip1, cyclin D1 and Ki-67 expression by immunohistochemistry. HPV was investigated by polymerase chain reaction (PCR). Results. HPV DNA was detected in 14/20 patients with inverted papillomas (IPs) (70%). The majority of tumours showed strong p16, p21, p27, pRb and cyclin D1 staining and little or no p53 expression. Tumours harbouring dysplasia were significantly more likely to be p53-positive and exhibit up-regulated p21 and p27, and showed altered intensity and distribution of reactive cells into and through the epithelium. Dysplastic epithelium was strongly reactive for p16 and the MIB 1 labelling index was almost 20%. These findings were associated with expression of p53 in the same zones. Comparing the p53 reactivity with the presence of HPV DNA, SIPs were stratified as follows: HPV + p53−, 12 (63.15%); HPV + p53+, 2 (10.52%); HPV − p53+, 3 (15.78%) and HPV − p53−, 2 (10.52%). Statistical analysis showed that HPV presence correlated with p53-positive immunostaining ( p=0.045). [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Group: Ab
  Data: <i>Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – TitleFull: Expression of p53, p16INK4A, pRb, p21WAF1/CIP1, p27KIP1, cyclin D1, Ki-67 and HPV DNA in sinonasal endophytic Schneiderian (inverted) papilloma.
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              Text: Nov2009
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