Angiogenic Factors in Laryngeal Carcinomas: Do They Have Prognostic Relevance?
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| Title: | Angiogenic Factors in Laryngeal Carcinomas: Do They Have Prognostic Relevance? |
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| Authors: | Burian, M., Quint, Ch., Neuchrist, C. |
| Source: | Acta Oto-Laryngologica. 4/22/99, Vol. 119 Issue 2, p289-292. 4p. |
| Abstract: | Angiogenesis is a cascade-like mechanism essential for tumour growth and metastasis. Recently developed inhibitors of angiogenesis have already proven their benefit in anticancer treatment. Therefore the existence of angiogenic molecules in individual tumours is of major interest. The factors most frequently contributing to angiogenesis are basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF) and some matrix metalloproteinases (MMPs). In order to evaluate the prognostic significance of these molecules we investigated the distribution pattern of VEGF, bFGF, MMP-2 and MMP-9 in 41 laryngeal carcinomas using immunohistochemical methods. The results were correlated with clinicopathological parameters, i.e. T and N stage, histological grading, freedom from disease, overall survival and microvessel density (MVD). Only VEGF revealed a correlation with MVD (p=0.01) and a weak association with histological grading (p=0.06). Even though there is controversy about published data on the prognostic relevance of angiogenic factors, our results suggest that the factors examined in this study are not suitable for prognosis in larynx cancer patients. [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 4876026 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Angiogenic Factors in Laryngeal Carcinomas: Do They Have Prognostic Relevance? – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Burian%2C+M%2E%22">Burian, M.</searchLink><br /><searchLink fieldCode="AR" term="%22Quint%2C+Ch%2E%22">Quint, Ch.</searchLink><br /><searchLink fieldCode="AR" term="%22Neuchrist%2C+C%2E%22">Neuchrist, C.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Oto-Laryngologica%22">Acta Oto-Laryngologica</searchLink>. 4/22/99, Vol. 119 Issue 2, p289-292. 4p. – Name: Abstract Label: Abstract Group: Ab Data: Angiogenesis is a cascade-like mechanism essential for tumour growth and metastasis. Recently developed inhibitors of angiogenesis have already proven their benefit in anticancer treatment. Therefore the existence of angiogenic molecules in individual tumours is of major interest. The factors most frequently contributing to angiogenesis are basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF) and some matrix metalloproteinases (MMPs). In order to evaluate the prognostic significance of these molecules we investigated the distribution pattern of VEGF, bFGF, MMP-2 and MMP-9 in 41 laryngeal carcinomas using immunohistochemical methods. The results were correlated with clinicopathological parameters, i.e. T and N stage, histological grading, freedom from disease, overall survival and microvessel density (MVD). Only VEGF revealed a correlation with MVD (p=0.01) and a weak association with histological grading (p=0.06). Even though there is controversy about published data on the prognostic relevance of angiogenic factors, our results suggest that the factors examined in this study are not suitable for prognosis in larynx cancer patients. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1080/00016489950181846 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 4 StartPage: 289 Titles: – TitleFull: Angiogenic Factors in Laryngeal Carcinomas: Do They Have Prognostic Relevance? Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Burian, M. – PersonEntity: Name: NameFull: Quint, Ch. – PersonEntity: Name: NameFull: Neuchrist, C. IsPartOfRelationships: – BibEntity: Dates: – D: 22 M: 04 Text: 4/22/99 Type: published Y: 1999 Identifiers: – Type: issn-print Value: 00016489 Numbering: – Type: volume Value: 119 – Type: issue Value: 2 Titles: – TitleFull: Acta Oto-Laryngologica Type: main |
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