View in EDS PDF Full Text

DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis.

Saved in:
Bibliographic Details
Title: DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis.
Authors: Mössner, Rainald, Schuhmacher, Anna, Wagner, Michael, Quednow, Boris B., Frommann, Ingo, Kühn, Kai-Uwe, Schwab, Sibylle G., Rietschel, Marcella, Falkai, Peter, Wölwer, Wolfgang, Ruhrmann, Stephan, Bechdolf, Andreas, Gaebel, Wolfgang, Klosterkötter, Joachim, Maier, Wolfgang
Source: European Archives of Psychiatry & Clinical Neuroscience. Apr2010, Vol. 260 Issue 3, p209-215. 7p. 1 Diagram, 4 Charts.
Subjects: Psychoses, Syndromes, Disease progression, Schizophrenia, Amino acids
Abstract: The genetic factors determining the progression of prodromal syndromes to first episode schizophrenia have remained enigmatic to date. In a unique prospective multicentre trial, we assessed whether variants at the d-amino acid oxidase activator (DAOA)/G72 locus influence progression to psychosis. Young subjects with a prodromal syndrome were observed prospectively for up to 2 years to assess the incidence of progression to schizophrenia or first episode psychosis. Of the 82 probands with a prodromal syndrome, 21 probands experienced progression to psychosis within the observation period. Assessment of nine common variants in the DAOA/G72 locus yielded two variants with the predictive value for symptom progression: all four probands with the rs1341402 CC genotype developed psychosis compared with 17 out of 78 probands with the TT or CT genotypes (χ2 = 12.348; df = 2; p = 0.002). The relative risk for progression to psychosis was significantly increased in the CC genotype: RR = 4.588 (95% CI = 2.175–4.588). Similarly, for rs778294, 50% of probands with the AA genotype, but only 22% of probands with a GG or GA genotype progressed to psychosis (χ2 = 7.027; df = 2; p = 0.030). Moreover, haplotype analysis revealed a susceptibility haplotype for progression to psychosis. This is one of the first studies to identify a specific genetic factor for the progression of prodromal syndromes to schizophrenia, and further underscores the importance of the DAOA/G72 gene for schizophrenia. [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 49086828
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Mössner%2C+Rainald%22">Mössner, Rainald</searchLink><br /><searchLink fieldCode="AR" term="%22Schuhmacher%2C+Anna%22">Schuhmacher, Anna</searchLink><br /><searchLink fieldCode="AR" term="%22Wagner%2C+Michael%22">Wagner, Michael</searchLink><br /><searchLink fieldCode="AR" term="%22Quednow%2C+Boris+B%2E%22">Quednow, Boris B.</searchLink><br /><searchLink fieldCode="AR" term="%22Frommann%2C+Ingo%22">Frommann, Ingo</searchLink><br /><searchLink fieldCode="AR" term="%22Kühn%2C+Kai-Uwe%22">Kühn, Kai-Uwe</searchLink><br /><searchLink fieldCode="AR" term="%22Schwab%2C+Sibylle+G%2E%22">Schwab, Sibylle G.</searchLink><br /><searchLink fieldCode="AR" term="%22Rietschel%2C+Marcella%22">Rietschel, Marcella</searchLink><br /><searchLink fieldCode="AR" term="%22Falkai%2C+Peter%22">Falkai, Peter</searchLink><br /><searchLink fieldCode="AR" term="%22Wölwer%2C+Wolfgang%22">Wölwer, Wolfgang</searchLink><br /><searchLink fieldCode="AR" term="%22Ruhrmann%2C+Stephan%22">Ruhrmann, Stephan</searchLink><br /><searchLink fieldCode="AR" term="%22Bechdolf%2C+Andreas%22">Bechdolf, Andreas</searchLink><br /><searchLink fieldCode="AR" term="%22Gaebel%2C+Wolfgang%22">Gaebel, Wolfgang</searchLink><br /><searchLink fieldCode="AR" term="%22Klosterkötter%2C+Joachim%22">Klosterkötter, Joachim</searchLink><br /><searchLink fieldCode="AR" term="%22Maier%2C+Wolfgang%22">Maier, Wolfgang</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Apr2010, Vol. 260 Issue 3, p209-215. 7p. 1 Diagram, 4 Charts.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Psychoses%22">Psychoses</searchLink><br /><searchLink fieldCode="DE" term="%22Syndromes%22">Syndromes</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+progression%22">Disease progression</searchLink><br /><searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Amino+acids%22">Amino acids</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The genetic factors determining the progression of prodromal syndromes to first episode schizophrenia have remained enigmatic to date. In a unique prospective multicentre trial, we assessed whether variants at the d-amino acid oxidase activator (DAOA)/G72 locus influence progression to psychosis. Young subjects with a prodromal syndrome were observed prospectively for up to 2 years to assess the incidence of progression to schizophrenia or first episode psychosis. Of the 82 probands with a prodromal syndrome, 21 probands experienced progression to psychosis within the observation period. Assessment of nine common variants in the DAOA/G72 locus yielded two variants with the predictive value for symptom progression: all four probands with the rs1341402 CC genotype developed psychosis compared with 17 out of 78 probands with the TT or CT genotypes (χ2 = 12.348; df = 2; p = 0.002). The relative risk for progression to psychosis was significantly increased in the CC genotype: RR = 4.588 (95% CI = 2.175–4.588). Similarly, for rs778294, 50% of probands with the AA genotype, but only 22% of probands with a GG or GA genotype progressed to psychosis (χ2 = 7.027; df = 2; p = 0.030). Moreover, haplotype analysis revealed a susceptibility haplotype for progression to psychosis. This is one of the first studies to identify a specific genetic factor for the progression of prodromal syndromes to schizophrenia, and further underscores the importance of the DAOA/G72 gene for schizophrenia. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=49086828
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00406-009-0044-y
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 209
    Subjects:
      – SubjectFull: Psychoses
        Type: general
      – SubjectFull: Syndromes
        Type: general
      – SubjectFull: Disease progression
        Type: general
      – SubjectFull: Schizophrenia
        Type: general
      – SubjectFull: Amino acids
        Type: general
    Titles:
      – TitleFull: DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Mössner, Rainald
      – PersonEntity:
          Name:
            NameFull: Schuhmacher, Anna
      – PersonEntity:
          Name:
            NameFull: Wagner, Michael
      – PersonEntity:
          Name:
            NameFull: Quednow, Boris B.
      – PersonEntity:
          Name:
            NameFull: Frommann, Ingo
      – PersonEntity:
          Name:
            NameFull: Kühn, Kai-Uwe
      – PersonEntity:
          Name:
            NameFull: Schwab, Sibylle G.
      – PersonEntity:
          Name:
            NameFull: Rietschel, Marcella
      – PersonEntity:
          Name:
            NameFull: Falkai, Peter
      – PersonEntity:
          Name:
            NameFull: Wölwer, Wolfgang
      – PersonEntity:
          Name:
            NameFull: Ruhrmann, Stephan
      – PersonEntity:
          Name:
            NameFull: Bechdolf, Andreas
      – PersonEntity:
          Name:
            NameFull: Gaebel, Wolfgang
      – PersonEntity:
          Name:
            NameFull: Klosterkötter, Joachim
      – PersonEntity:
          Name:
            NameFull: Maier, Wolfgang
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: Apr2010
              Type: published
              Y: 2010
          Identifiers:
            – Type: issn-print
              Value: 09401334
          Numbering:
            – Type: volume
              Value: 260
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: European Archives of Psychiatry & Clinical Neuroscience
              Type: main
ResultId 1