C. elegans phototransduction requires a G protein–dependent cGMP pathway and a taste receptor homolog.
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| Title: | C. elegans phototransduction requires a G protein–dependent cGMP pathway and a taste receptor homolog. |
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| Authors: | Jie Liu, Ward, Alex, Jingwei Gao, Yongming Dong, Nishio, Nana, Inada, Hitoshi, Lijun Kang, Yong Yu, Di Ma, Tao Xu, Mori, Ikue, Zhixiong Xie, Xu, X. Z. Shawn |
| Source: | Nature Neuroscience. Jun2010, Vol. 13 Issue 6, p715-722. 8p. 7 Graphs. |
| Subjects: | Phototaxis, Animal orientation, Photoreceptors, Sense organs, G proteins, Neurons |
| Abstract: | The eyeless animal C. elegans is able to sense light and engages in phototaxis behavior that is mediated by photoreceptor cells. However, the molecular and cellular mechanisms underlying phototransduction in C. elegans remain largely unclear. By recording the photoreceptor neuron ASJ in wild-type and various mutant worms, we found that phototransduction in ASJ is a G protein–mediated process and requires membrane-associated guanylate cyclases, but not typical phosphodiesterases. In addition, we found that C. elegans phototransduction requires LITE-1, a candidate photoreceptor protein known to be a member of the invertebrate taste receptor family. Our genetic, pharmacological and electrophysiological data suggest a model in which LITE-1 transduces light signals in ASJ via G protein signaling, which leads to upregulation of the second messenger cGMP, followed by opening of cGMP-sensitive CNG channels and stimulation of photoreceptor cells. Our results identify a phototransduction cascade in C. elegans and implicate the function of a 'taste receptor' in phototransduction. [ABSTRACT FROM AUTHOR] |
| Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 50833638 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: C. elegans phototransduction requires a G protein–dependent cGMP pathway and a taste receptor homolog. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Jie+Liu%22">Jie Liu</searchLink><br /><searchLink fieldCode="AR" term="%22Ward%2C+Alex%22">Ward, Alex</searchLink><br /><searchLink fieldCode="AR" term="%22Jingwei+Gao%22">Jingwei Gao</searchLink><br /><searchLink fieldCode="AR" term="%22Yongming+Dong%22">Yongming Dong</searchLink><br /><searchLink fieldCode="AR" term="%22Nishio%2C+Nana%22">Nishio, Nana</searchLink><br /><searchLink fieldCode="AR" term="%22Inada%2C+Hitoshi%22">Inada, Hitoshi</searchLink><br /><searchLink fieldCode="AR" term="%22Lijun+Kang%22">Lijun Kang</searchLink><br /><searchLink fieldCode="AR" term="%22Yong+Yu%22">Yong Yu</searchLink><br /><searchLink fieldCode="AR" term="%22Di+Ma%22">Di Ma</searchLink><br /><searchLink fieldCode="AR" term="%22Tao+Xu%22">Tao Xu</searchLink><br /><searchLink fieldCode="AR" term="%22Mori%2C+Ikue%22">Mori, Ikue</searchLink><br /><searchLink fieldCode="AR" term="%22Zhixiong+Xie%22">Zhixiong Xie</searchLink><br /><searchLink fieldCode="AR" term="%22Xu%2C+X%2E+Z%2E+Shawn%22">Xu, X. Z. Shawn</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Nature+Neuroscience%22">Nature Neuroscience</searchLink>. Jun2010, Vol. 13 Issue 6, p715-722. 8p. 7 Graphs. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Phototaxis%22">Phototaxis</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+orientation%22">Animal orientation</searchLink><br /><searchLink fieldCode="DE" term="%22Photoreceptors%22">Photoreceptors</searchLink><br /><searchLink fieldCode="DE" term="%22Sense+organs%22">Sense organs</searchLink><br /><searchLink fieldCode="DE" term="%22G+proteins%22">G proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Neurons%22">Neurons</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The eyeless animal C. elegans is able to sense light and engages in phototaxis behavior that is mediated by photoreceptor cells. However, the molecular and cellular mechanisms underlying phototransduction in C. elegans remain largely unclear. By recording the photoreceptor neuron ASJ in wild-type and various mutant worms, we found that phototransduction in ASJ is a G protein–mediated process and requires membrane-associated guanylate cyclases, but not typical phosphodiesterases. In addition, we found that C. elegans phototransduction requires LITE-1, a candidate photoreceptor protein known to be a member of the invertebrate taste receptor family. Our genetic, pharmacological and electrophysiological data suggest a model in which LITE-1 transduces light signals in ASJ via G protein signaling, which leads to upregulation of the second messenger cGMP, followed by opening of cGMP-sensitive CNG channels and stimulation of photoreceptor cells. Our results identify a phototransduction cascade in C. elegans and implicate the function of a 'taste receptor' in phototransduction. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1038/nn.2540 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 715 Subjects: – SubjectFull: Phototaxis Type: general – SubjectFull: Animal orientation Type: general – SubjectFull: Photoreceptors Type: general – SubjectFull: Sense organs Type: general – SubjectFull: G proteins Type: general – SubjectFull: Neurons Type: general Titles: – TitleFull: C. elegans phototransduction requires a G protein–dependent cGMP pathway and a taste receptor homolog. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Jie Liu – PersonEntity: Name: NameFull: Ward, Alex – PersonEntity: Name: NameFull: Jingwei Gao – PersonEntity: Name: NameFull: Yongming Dong – PersonEntity: Name: NameFull: Nishio, Nana – PersonEntity: Name: NameFull: Inada, Hitoshi – PersonEntity: Name: NameFull: Lijun Kang – PersonEntity: Name: NameFull: Yong Yu – PersonEntity: Name: NameFull: Di Ma – PersonEntity: Name: NameFull: Tao Xu – PersonEntity: Name: NameFull: Mori, Ikue – PersonEntity: Name: NameFull: Zhixiong Xie – PersonEntity: Name: NameFull: Xu, X. Z. Shawn IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2010 Type: published Y: 2010 Identifiers: – Type: issn-print Value: 10976256 Numbering: – Type: volume Value: 13 – Type: issue Value: 6 Titles: – TitleFull: Nature Neuroscience Type: main |
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